Myosins and Hearing

Friedman, Thomas B.; Belyantseva, Inna A.; Frolenkov, Gregory I.

doi:10.1007/978-3-030-38062-5_13

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1239))

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27 Citations
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Abstract

Hearing loss is both genetically and clinically heterogeneous, and pathogenic variants of over a hundred different genes are associated with this common neurosensory disorder. A relatively large number of these “deafness genes” encode myosin super family members. The evidence that pathogenic variants of human MYO3A, MYO6, MYO7A, MYO15A, MYH14 and MYH9 are associated with deafness ranges from moderate to definitive. Additional evidence for the involvement of these six myosins for normal hearing also comes from animal models, usually mouse or zebra fish, where mutations of these genes cause hearing loss and from biochemical, physiological and cell biological studies of their roles in the inner ear. This chapter focuses on these six genes for which evidence of a causative role in deafness is substantial.

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Acknowledgements

This research was supported (in part) by the Intramural Research Program of the NIH, National Institute on Deafness and Other Communication Disorders to T.B.F and by R01DC014658, R01DC012564, and S10OD025130 grants to G.I.F. We thank Dr. Mhamed Grati for his critique of this chapter.

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Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, Porter Neuroscience Research Center, National Institutes of Health, Bethesda, MD, USA
Thomas B. Friedman & Inna A. Belyantseva
Department of Physiology, University of Kentucky College of Medicine, Lexington, KY, USA
Gregory I. Frolenkov

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Thomas B. Friedman
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Inna A. Belyantseva
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Gregory I. Frolenkov
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Department of Physiology & Biophysics, Boston University School of Medicine, Boston, MA, USA
Lynne M. Coluccio

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Friedman, T.B., Belyantseva, I.A., Frolenkov, G.I. (2020). Myosins and Hearing. In: Coluccio, L. (eds) Myosins. Advances in Experimental Medicine and Biology, vol 1239. Springer, Cham. https://doi.org/10.1007/978-3-030-38062-5_13

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