Skip to main content
Springer Nature Link
Log in

Nickel and Human Health

  • Chapter
  • First Online:
Interrelations between Essential Metal Ions and Human Diseases

Part of the book series: Metal Ions in Life Sciences ((MILS,volume 13))

Abstract

This review focuses on the impact of nickel on human health. In particular, the dual nature of nickel as an essential as well as toxic element in nature is described, and the main forms of nickel that can come in contact with living systems from natural sources and anthropogenic activities are discussed. Concomitantly, the main routes of nickel uptake and transport in humans are covered, and the potential dangers that nickel exposure can represent for health are described. In particular, the insurgence of nickel-derived allergies, nickel-induced carcinogenesis as well as infectious diseases caused by human pathogens that rely on nickel-based enzymes to colonize the host are reviewed at different levels, from their macroscopic aspects on human health to the molecular mechanisms underlying these points. Finally, the importance of nickel as a beneficial element for human health, especially being essential for microorganisms that colonize the human guts, is examined.

Please cite as: Met. Ions Life Sci. 13 (2013) 321–357

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+ Basic
€34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
EUR 29.95
Price includes VAT (Germany)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
EUR 160.49
Price includes VAT (Germany)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
EUR 213.99
Price includes VAT (Germany)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
EUR 213.99
Price includes VAT (Germany)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

') var buybox = document.querySelector("[data-id=id_"+ timestamp +"]").parentNode var buyingOptions = buybox.querySelectorAll(".buying-option") ;[].slice.call(buyingOptions).forEach(initCollapsibles) var buyboxMaxSingleColumnWidth = 480 function initCollapsibles(subscription, index) { var toggle = subscription.querySelector(".buying-option-price") subscription.classList.remove("expanded") var form = subscription.querySelector(".buying-option-form") var priceInfo = subscription.querySelector(".price-info") var buyingOption = toggle.parentElement if (toggle && form && priceInfo) { toggle.setAttribute("role", "button") toggle.setAttribute("tabindex", "0") toggle.addEventListener("click", function (event) { var expandedBuyingOptions = buybox.querySelectorAll(".buying-option.expanded") var buyboxWidth = buybox.offsetWidth ;[].slice.call(expandedBuyingOptions).forEach(function(option) { if (buyboxWidth buyboxMaxSingleColumnWidth) { toggle.click() } else { if (index === 0) { toggle.click() } else { toggle.setAttribute("aria-expanded", "false") form.hidden = "hidden" priceInfo.hidden = "hidden" } } }) } initialStateOpen() if (window.buyboxInitialised) return window.buyboxInitialised = true initKeyControls() })()

Institutional subscriptions

Similar content being viewed by others

References

  1. S. Ciurli, S. Mangani, in Handbook on Metalloproteins, Eds. I. Bertini, A. Sigel, H. Sigel, Marcel Dekker, New York, USA, 2001, pp. 669–708.

    Google Scholar 

  2. E. Merian, Toxicol. Envir. Chem. 1984, 8, 9–38.

    CAS  Google Scholar 

  3. R. G. Garrett, in Metal Ions in Biology and Medicine, Eds J. A. Centeno, P. Collery, G. Fernet, R. B. Finkelman, H. Gibb, J.-C. Etienne; John Libbey Eurotext, Paris, 2000, Vol. 6, pp. 508–510.

    Google Scholar 

  4. C. L. Coyle, E. I. Stiefel, in The Bioinorganic Chemistry of Nickel, Ed J. R. Lancaster, Jr., VCH, New York, 1988, pp. 1–28.

    Google Scholar 

  5. E. Denkhaus, K. Salnikow, Crit. Rev. Oncol. Hematol. 2002, 42, 35–56.

    CAS  PubMed  Google Scholar 

  6. D. G. Barceloux, J. Toxicol. Clin. Toxicol. 1999, 37, 239–258.

    CAS  PubMed  Google Scholar 

  7. M. Van Soestbergen, F. W. Sunderman, Jr., Clin. Chem. 1972, 18, 1478–1484.

    PubMed  Google Scholar 

  8. N. Asato, M. Soestbergen, F. W. Sunderman, Jr., Clin. Chem. 1975, 21, 521–527.

    CAS  PubMed  Google Scholar 

  9. J. D. Glennon, B. Sarkar, Biochem. J. 1982, 203, 15–23.

    CAS  PubMed Central  PubMed  Google Scholar 

  10. F. Torres, M. das Gracas, M. Melo, A. Tosti, Clin. Cosmet. Investig. Dermatol. 2009, 2, 39–48.

    Google Scholar 

  11. R. B. Schiffer, F. W. Sunderman, Jr., R. B. Baggs, J. A. Moynihan, J. Neuroimmunol. 1991, 34, 229–239.

    CAS  PubMed  Google Scholar 

  12. M. Freitas, P. Barcellos-de-Souza, C. Barja-Fidalgo, E. Fernandes, BioMetals 2013, 26, 13–21.

    CAS  PubMed  Google Scholar 

  13. A. Au, J. Ha, M. Hernandez, A. Polotsky, D. S. Hungerford, C. G. Frondoza, J. Biomed. Mater. Res. A 2006, 79, 512–521.

    PubMed  Google Scholar 

  14. M. Anke, A. Trüpschuch, G. Gunstheimer, in Trace Elements in Man and Animals 10, Eds A. M. Roussel, R. A. Anderson, A. E. Favrier, Kluwer Academic, 2002, pp. 685–686.

    Google Scholar 

  15. S. G. Schafer, W. Forth, Ecotoxicol. Environ. Saf. 1983, 7, 87–95.

    CAS  PubMed  Google Scholar 

  16. J. Tallkvist, A. M. Wing, H. Tjalve, Pharmacol. Toxicol. 1994, 75, 244–249.

    CAS  PubMed  Google Scholar 

  17. M. Muller-Fassbender, B. Elsenhans, A. T. McKie, K. Schumann, Toxicology 2003, 185, 141–153.

    CAS  PubMed  Google Scholar 

  18. International Agency for Research on Cancer, "Chromium, Nickel and Welding", Proceedings of the Monographs on the Evaluation of Carcenigenic Risks to Humans, Lyon, France, 1990.

    Google Scholar 

  19. F. H. Nielsen, D. A. Ollerich, Fed. Proc. 1974, 33, 1767–1772.

    CAS  PubMed  Google Scholar 

  20. Y. Li, D. B. Zamble, Chem. Rev. 2009, 109, 4617–4643.

    CAS  PubMed  Google Scholar 

  21. M. Yusuf, Q. Fariduddin, S. Hayat, A. Ahmad, Bull. Environ. Contam. Toxicol. 2011, 86, 1–17.

    CAS  PubMed  Google Scholar 

  22. EMEA, European Medicines Agency, 2008; http://www.ema.europa.eu/ema.

  23. K. S. Kasprzak, K. Salnikow, in Nickel and Its Surprising Impact in Nature, Vol. 2 of Metal Ions in Life Sciences, Eds A. Sigel, H. Sigel, R. K. O. Sigel, Wiley, Chichester, 2007, Vol. 2, pp. 581–618.

    Google Scholar 

  24. K. S. Kasprzak, F. W. Sunderman, Jr., K. Salnikow, Mutat. Res. 2003, 533, 67–97.

    CAS  PubMed  Google Scholar 

  25. H. M. Shen, Q. F. Zhang, Environ. Health Perspect. 1994, 102 (Suppl. 1), 275–282.

    CAS  PubMed Central  PubMed  Google Scholar 

  26. A. R. Oller, M. Costa, G. Oberdorster, Toxicol. Appl. Pharmacol. 1997, 143, 152–166.

    CAS  PubMed  Google Scholar 

  27. K. A. Biedermann, J. R. Landolph, Cancer Res. 1987, 47, 3815–3823.

    CAS  PubMed  Google Scholar 

  28. M. Costa, T. L. Davidson, H. Chen, Q. Ke, P. Zhang, Y. Yan, C. Huang, T. Kluz, Mutat. Res. 2005, 592, 79–88.

    CAS  PubMed  Google Scholar 

  29. N. W. Biggart, M. Costa, Mutat. Res. 1986, 175, 209–215.

    CAS  PubMed  Google Scholar 

  30. J. B. Little, J. M. Frenial, J. Coppey, Teratog. Carcinog. Mutagen. 1988, 8, 287–292.

    CAS  PubMed  Google Scholar 

  31. T. Miura, S. R. Patierno, T. Sakuramoto, J. R. Landolph, Environ. Mol. Mutagen. 1989, 14, 65–78.

    CAS  PubMed  Google Scholar 

  32. F. Z. Arrouijal, H. F. Hildebrand, H. Vophi, D. Marzin, Mutagenesis 1990, 5, 583–589.

    CAS  PubMed  Google Scholar 

  33. B. Kargacin, C. B. Klein, M. Costa, Mutat. Res. 1993, 300, 63–72.

    CAS  PubMed  Google Scholar 

  34. M. Freitas, A. Gomes, G. Porto, E. Fernandes, J. Biol. Inorg. Chem. 2010, 15, 1275–1283.

    CAS  PubMed  Google Scholar 

  35. T. J. O’Brien, S. Ceryak, S. R. Patierno, Mutat. Res. 2003, 533, 3–36.

    PubMed  Google Scholar 

  36. B. Desoize, In Vivo 2003, 17, 529–539.

    CAS  PubMed  Google Scholar 

  37. A. Hartwig, T. Schwerdtle, Toxicol. Lett. 2002, 127, 47–54.

    CAS  PubMed  Google Scholar 

  38. W. Bal, R. Liang, J. Lukszo, S. H. Lee, M. Dizdaroglu, K. S. Kasprzak, Chem. Res. Toxicol. 2000, 13, 616–624.

    CAS  PubMed  Google Scholar 

  39. L. Lande-Diner, J. Zhang, T. Hashimshony, A. Goren, I. Keshet, H. Cedar, Cold Spring Harb. Symp. Quant. Biol. 2004, 69, 131–138.

    CAS  PubMed  Google Scholar 

  40. Y. W. Lee, C. B. Klein, B. Kargacin, K. Salnikow, J. Kitahara, K. Dowjat, A. Zhitkovich, N. T. Christie, M. Costa, Mol. Cell. Biol. 1995, 15, 2547–2557.

    CAS  PubMed Central  PubMed  Google Scholar 

  41. B. Govindarajan, R. Klafter, M. S. Miller, C. Mansur, M. Mizesko, X. Bai, K. LaMontagne, Jr., J. L. Arbiser, Mol. Med. 2002, 8, 1–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  42. K. Salnikow, A. Zhitkovich, Chem. Res. Toxicol. 2008, 21, 28–44.

    PubMed Central  PubMed  Google Scholar 

  43. H. Chen, Q. Ke, T. Kluz, Y. Yan, M. Costa, Mol. Cell. Biol. 2006, 26, 3728–3737.

    CAS  PubMed Central  PubMed  Google Scholar 

  44. H. Chen, N. C. Giri, R. Zhang, K. Yamane, Y. Zhang, M. Maroney, M. Costa, J. Biol. Chem. 2010, 285, 7374–7383.

    CAS  PubMed Central  PubMed  Google Scholar 

  45. R. Martinez-Zamudio, H. C. Ha, Epigenetics 2011, 6, 820–882.

    CAS  PubMed Central  PubMed  Google Scholar 

  46. A. A. Karaczyn, F. Golebiowski, K. S. Kasprzak, Chem. Res. Toxicol. 2005, 18, 1934–1942.

    CAS  PubMed  Google Scholar 

  47. Q. Zhang, K. Salnikow, T. Kluz, L. C. Chen, W. C. Su, M. Costa, Toxicol. Appl. Pharmacol. 2003, 192, 201–211.

    CAS  PubMed  Google Scholar 

  48. C. B. Klein, K. Conway, X. W. Wang, R. K. Bhamra, X. H. Lin, M. D. Cohen, L. Annab, J. C. Barrett, M. Costa, Science 1991, 251, 796–799.

    CAS  PubMed  Google Scholar 

  49. S. Orrenius, B. Zhivotovsky, P. Nicotera, Nat. Rev. Mol. Cell. Biol. 2003, 4, 552–565.

    CAS  PubMed  Google Scholar 

  50. K. Salnikow, M. Gao, V. Voitkun, X. Huang, M. Costa, Cancer Res. 1994, 54, 6407–6412.

    CAS  PubMed  Google Scholar 

  51. W. Bal, A. M. Protas, K. S. Kasprzak, in Metal Ions in Toxicology: Effects, Interactions, Interdependencies, Vol. 8 of Metal Ions in Life Sciences, Eds A. Sigel, H. Sigel, R. K. O. Sigel, Royal Society of Chemistry, Cambridge, 2011, pp. 319–373.

    Google Scholar 

  52. K. Salnikow, M. V. Blagosklonny, H. Ryan, R. Johnson, M. Costa, Cancer Res. 2000, 60, 38–41.

    CAS  PubMed  Google Scholar 

  53. S. Salceda, J. Caro, J. Biol. Chem. 1997, 272, 22642–22647.

    CAS  PubMed  Google Scholar 

  54. W. C. Hon, M. I. Wilson, K. Harlos, T. D. Claridge, C. J. Schofield, C. W. Pugh, P. H. Maxwell, P. J. Ratcliffe, D. I. Stuart, E. Y. Jones, Nature 2002, 417, 975–978.

    CAS  PubMed  Google Scholar 

  55. S. J. Freedman, Z. Y. Sun, F. Poy, A. L. Kung, D. M. Livingston, G. Wagner, M. J. Eck, Proc. Natl. Acad. Sci. USA 2002, 99, 5367–5372.

    CAS  PubMed Central  PubMed  Google Scholar 

  56. P. Maxwell, K. Salnikow, Cancer Biol. Ther. 2004, 3, 29–35.

    CAS  PubMed  Google Scholar 

  57. K. Salnikow, S. P. Donald, R. K. Bruick, A. Zhitkovich, J. M. Phang, K. S. Kasprzak, J. Biol. Chem. 2004, 279, 40337–40344.

    CAS  PubMed  Google Scholar 

  58. D. Zhou, K. Salnikow, M. Costa, Cancer Res. 1998, 58, 2182–2189.

    CAS  PubMed  Google Scholar 

  59. H. Cangul, K. Salnikow, H. Yee, D. Zagzag, T. Commes, M. Costa, Cell. Biol. Toxicol. 2002, 18, 87–96.

    CAS  PubMed  Google Scholar 

  60. T. P. Ellen, Q. Ke, P. Zhang, M. Costa, Carcinogenesis 2008, 29, 2–8.

    CAS  PubMed  Google Scholar 

  61. M. A. Zoroddu, M. Peana, T. Kowalik-Jankowska, H. Kozlowski, M. Costa, J. Inorg. Biochem. 2004, 98, 931–939.

    CAS  PubMed  Google Scholar 

  62. M. A. Zoroddu, M. Peana, S. Medici, R. Anedda, Dalton Trans. 2009, 5523–5534.

    Google Scholar 

  63. J. G. Burchfield, A. J. Lennard, S. Narasimhan, W. E. Hughes, V. C. Wasinger, G. L. Corthals, T. Okuda, H. Kondoh, T. J. Biden, C. Schmitz-Peiffer, J. Biol. Chem. 2004, 279, 18623–18632.

    CAS  PubMed  Google Scholar 

  64. J. Hwang, Y. Kim, H. B. Kang, L. Jaroszewski, A. M. Deacon, H. Lee, W. C. Choi, K. J. Kim, C. H. Kim, B. S. Kang, J. O. Lee, T. K. Oh, J. W. Kim, I. A. Wilson, M. H. Kim, J. Biol. Chem. 2011, 286, 12450–12460.

    CAS  PubMed Central  PubMed  Google Scholar 

  65. K. Kondo, T. Ozaki, Y. Nakamura, S. Sakiyama, Biochem. Biophys. Res. Commun. 1995, 216, 209–215.

    CAS  PubMed  Google Scholar 

  66. K. Kanaya, A. L. Tsai, T. Kamitani, Biochem. Biophys. Res. Commun. 2002, 290, 294–299.

    CAS  PubMed  Google Scholar 

  67. S. Oshiro, K. Nozawa, M. Hori, C. Zhang, Y. Hashimoto, S. Kitajima, K. Kawamura, Biochem. Biophys. Res. Commun. 2002, 290, 213–218.

    CAS  PubMed  Google Scholar 

  68. C. Harford, B. Sarkar, Biochem. Biophys. Res. Commun. 1995, 209, 877–882.

    CAS  PubMed  Google Scholar 

  69. S. F. Martin, P. R. Esser, F. C. Weber, T. Jakob, M. A. Freudenberg, M. Schmidt, M. Goebeler, Allergy 2011, 66, 1152–1163.

    CAS  PubMed  Google Scholar 

  70. M. Schmidt, M. Goebeler, J. Mol. Med. (Berl.) 2011, 89, 961–970.

    Google Scholar 

  71. P. S. Friedmann, Toxicol. Lett. 2006, 162, 49–54.

    CAS  PubMed  Google Scholar 

  72. K. Landsteiner, J. Jacobs, J. Exp. Med. 1935, 61, 643–656.

    CAS  PubMed Central  PubMed  Google Scholar 

  73. H. J. Thierse, K. Gamerdinger, C. Junkes, N. Guerreiro, H. U. Weltzien, Toxicology 2005, 209, 101–107.

    CAS  PubMed  Google Scholar 

  74. L. Lu, J. Vollmer, C. Moulon, H. U. Weltzien, P. Marrack, J. Kappler, J. Exp. Med. 2003, 197, 567–574.

    CAS  PubMed Central  PubMed  Google Scholar 

  75. S. Dai, F. Crawford, P. Marrack, J. W. Kappler, Proc. Natl. Acad. Sci. USA 2008, 105, 11893–11897.

    CAS  PubMed Central  PubMed  Google Scholar 

  76. F. Sinigaglia, J. Invest. Dermatol. 1994, 102, 398–401.

    CAS  PubMed  Google Scholar 

  77. Y. Wang, S. Dai, Immunol. Res. 2013, 55, 83–90.

    CAS  PubMed  Google Scholar 

  78. P. Griem, C. von Vultee, K. Panthel, S. L. Best, P. J. Sadler, C. F. Shaw, 3rd, Eur. J. Immunol. 1998, 28, 1941–1947.

    CAS  PubMed  Google Scholar 

  79. K. Gamerdinger, C. Moulon, D. R. Karp, J. Van Bergen, F. Koning, D. Wild, U. Pflugfelder, H. U. Weltzien, J. Exp. Med. 2003, 197, 1345–1353.

    CAS  PubMed Central  PubMed  Google Scholar 

  80. O. Wildner, T. Lipkow, J. Knop, Exp. Dermatol. 1992, 1, 191–198.

    CAS  PubMed  Google Scholar 

  81. M. Goebeler, G. Meinardus-Hager, J. Roth, S. Goerdt, C. Sorg, J. Invest. Dermatol. 1993, 100, 759–765.

    CAS  PubMed  Google Scholar 

  82. M. Goebeler, A. Trautmann, A. Voss, E. V. Brocker, A. Toksoy, R. Gillitzer, Am. J. Pathol. 2001, 158, 431–440.

    CAS  PubMed Central  PubMed  Google Scholar 

  83. M. Goebeler, J. Roth, E. B. Brocker, C. Sorg, K. Schulze-Osthoff, J. Immunol. 1995, 155, 2459–2467.

    CAS  PubMed  Google Scholar 

  84. M. Goebeler, R. Gillitzer, K. Kilian, K. Utzel, E. B. Brocker, U. R. Rapp, S. Ludwig, Blood 2001, 97, 46–55.

    CAS  PubMed  Google Scholar 

  85. M. Schmidt, B. Raghavan, V. Muller, T. Vogl, G. Fejer, S. Tchaptchet, S. Keck, C. Kalis, P. J. Nielsen, C. Galanos, J. Roth, A. Skerra, S. F. Martin, M. A. Freudenberg, M. Goebeler, Nat. Immunol. 2010, 11, 814–819.

    CAS  PubMed  Google Scholar 

  86. M. Schmidt, M. Hupe, N. Endres, B. Raghavan, S. Kavuri, P. Geserick, M. Goebeler, M. Leverkus, J. Cell. Mol. Med. 2010, 14, 1760–1776.

    CAS  PubMed  Google Scholar 

  87. A. Trautmann, M. Akdis, D. Kleemann, F. Altznauer, H. U. Simon, T. Graeve, M. Noll, E. B. Brocker, K. Blaser, C. A. Akdis, J. Clin. Invest. 2000, 106, 25–35.

    CAS  PubMed Central  PubMed  Google Scholar 

  88. S. Rothman, Dermatol. Wochenschr. 1930, 2, 98–99.

    Google Scholar 

  89. R. Spiewak, J. Pietowska, K. Curzytek, Expert Rev. Clin. Immunol. 2007, 3, 851–859.

    CAS  PubMed  Google Scholar 

  90. T. Menne, K. Rasmussen, Contact Dermatitis 1990, 23, 57–58.

    CAS  PubMed  Google Scholar 

  91. J. P. Thyssen, K. Ross-Hansen, T. Menne, J. D. Johansen, Contact Dermatitis 2010, 63, 102–106.

    PubMed  Google Scholar 

  92. Y. Yoshihisa, T. Shimizu, Dermatol. Res. Pract. 2012, 2012, 749561.

    PubMed Central  PubMed  Google Scholar 

  93. E. Mann, U. Ranft, G. Eberwein, D. Gladtke, D. Sugiri, H. Behrendt, J. Ring, T. Schafer, J. Begerow, J. Wittsiepe, U. Kramer, M. Wilhelm, Contact Dermatitis 2010, 62, 355–362.

    CAS  PubMed  Google Scholar 

  94. R. Darlenski, J. Kazandjieva, K. Pramatarov, Int. J. Dermatol. 2012, 51, 523–530.

    PubMed  Google Scholar 

  95. J. P. Thyssen, T. Menne, Chem. Res. Toxicol. 2010, 23, 309–318.

    CAS  PubMed  Google Scholar 

  96. R. I. Nijhawan, M. Molenda, M. J. Zirwas, S. E. Jacob, Dermatol. Clin. 2009, 27, 355–364,

    CAS  PubMed  Google Scholar 

  97. D. Bonamonte, A. Cristaudo, F. Nasorri, T. Carbone, O. De Pita, G. Angelini, A. Cavani, Contact Dermatitis 2011, 65, 293–301.

    CAS  PubMed  Google Scholar 

  98. M. Minelli, D. Schiavino, F. Musca, M. E. Bruno, P. Falagiani, G. Mistrello, G. Riva, M. Braga, M. C. Turi, V. Di Rienzo, C. Petrarca, C. Schiavone, M. Di Gioacchino, Int. J. Immunopathol. Pharmacol. 2010, 23, 193–201.

    CAS  PubMed  Google Scholar 

  99. Nickel and Its Surprising Impact in Nature, Eds A. Sigel, H. Sigel, R. K. O. Sigel, John Wiley & Sons, Chichester, Met. Ions Life Sci. 2007, 2, pp. 1–702.

    Google Scholar 

  100. S. W. Ragsdale, J. Biol. Chem. 2009, 284, 18571–18575.

    CAS  PubMed Central  PubMed  Google Scholar 

  101. H. L. Mobley, M. D. Island, R. P. Hausinger, Microbiol. Rev. 1995, 59, 451–480.

    CAS  PubMed Central  PubMed  Google Scholar 

  102. S. Wyllie, A. H. Fairlamb, Semin. Cell. Dev. Biol. 2011, 22, 271–277.

    CAS  PubMed Central  PubMed  Google Scholar 

  103. N. Sukdeo, E. Daub, J. F. Honek, in Nickel and Its Surprising Impact in Nature, Vol. 2 of Metal Ions in Life Sciences, Eds A. Sigel, H. Sigel, R. K. O Sigel, John Wiley & Sons, Chichester, 2007, pp. 445–472.

    Google Scholar 

  104. N. Sukdeo, J. F. Honek, Biochim. Biophys. Acta 2007, 1774, 756–763.

    CAS  PubMed  Google Scholar 

  105. T. C. Pochapsky, T. Ju, M. Dang, R. Beaulieu, G. M. Pagani, B. OuYang, in Nickel and Its Surprising Impact in Nature, Vol. 2 of Metal Ions in Life Sciences, Eds A. Sigel, H. Sigel, R. K. O Sigel, John Wiley & Sons, Chichester, 2007, Vol. 2, pp. 473–500.

    Google Scholar 

  106. Q. Xu, R. Schwarzenbacher, S. S. Krishna, D. McMullan, S. Agarwalla, K. Quijano, P. Abdubek, E. Ambing, H. Axelrod, T. Biorac, J. M. Canaves, H.-J. Chiu, M.-A. Elsliger, C. Grittini, S. K. Grzechnik, M. DiDonato, J. Hale, E. Hampton, G. W. Han, J. Haugen, M. Hornsby, L. Jaroszewski, H. E. Klock, M. W. Knuth, E. Koesema, A. Kreusch, P. Kuhn, M. D. Miller, K. Moy, E. Nigoghossian, J. Paulsen, R. Reyes, C. Rife, G. Spraggon, R. C. Stevens, H. van den Bedem, J. Velasquez, A. White, G. Wolf, K. O. Hodgson, J. Wooley, A. M. Deacon, A. Godzik, S. A. Lesley, I. A. Wilson, Proteins: Structure, Function, and Bioinformatics 2006, 64, 808–813.

    CAS  Google Scholar 

  107. T. Ju, R. B. Goldsmith, S. C. Chai, M. J. Maroney, S. S. Pochapsky, T. C. Pochapsky, J. Mol. Biol. 2006, 363, 823–834.

    CAS  PubMed Central  PubMed  Google Scholar 

  108. S. Ciurli, in Nickel and Its Surprising Impact in Nature, Vol. 2 of Metal Ions in Life Sciences, Eds A. Sigel, H. Sigel, R. K. O Sigel, Wiley, Chichester, 2007, pp. 241–278.

    Google Scholar 

  109. B. Zambelli, F. Musiani, S. Benini, S. Ciurli, Acc. Chem. Res. 2011, 44, 520–530.

    CAS  PubMed  Google Scholar 

  110. S. Benini, W. R. Rypniewski, K. S. Wilson, S. Miletti, S. Ciurli, S. Mangani, Structure Fold. Des. 1999, 7, 205–216.

    CAS  PubMed  Google Scholar 

  111. F. Musiani, E. Arnofi, R. Casadio, S. Ciurli, J. Biol. Inorg. Chem. 2001, 3, 300–314.

    Google Scholar 

  112. S. Benini, W. R. Rypniewski, K. S. Wilson, S. Mangani, S. Ciurli, J. Am. Chem. Soc. 2004, 126, 3714–3715.

    CAS  PubMed  Google Scholar 

  113. S. Ciurli, S. Benini, W. R. Rypniewski, K. S. Wilson, S. Miletti, S. Mangani, Coord. Chem. Rev. 1999, 190–192, 331–355.

    Google Scholar 

  114. W. Lubitz, M. van Gastel, W. Gartner, Nickel and Its Surprising Impact in Nature, Vol. 2 of Metal Ions in Life Sciences, Eds A. Sigel, H. Sigel, R. K. O Sigel, John Wiley & Sons, Chichester, 2007, pp. 279–322.

    Google Scholar 

  115. P. M. Vignais, B. Billoud, Chem. Rev. 2007, 107, 4206–4272.

    CAS  PubMed  Google Scholar 

  116. R. J. Maier, Biochem. Soc. Trans. 2005, 33, 83–85.

    CAS  PubMed  Google Scholar 

  117. C. Navarro, L.-F. Wu, M.-A. Mandrand-Berthelot, Mol. Microbiol. 1993, 9, 1181–1191.

    CAS  PubMed  Google Scholar 

  118. H. Lebrette, M. Iannello, J. C. Fontecilla-Camps, C. Cavazza, J. Inorg. Biochem. 2013, 121, 16–18.

    CAS  PubMed  Google Scholar 

  119. L. Macomber, R. P. Hausinger, Metallomics 2011, 3, 1153–1162.

    CAS  PubMed  Google Scholar 

  120. D. H. Nies, FEMS Microbiol. Rev. 2003, 27, 313–339.

    CAS  PubMed  Google Scholar 

  121. F. N. Stahler, S. Odenbreit, R. Haas, J. Wilrich, A. H. Van Vliet, J. G. Kusters, M. Kist, S. Bereswill, Infect. Immun. 2006, 74, 3845–3852.

    PubMed Central  PubMed  Google Scholar 

  122. A. Rodrigue, G. Effantin, M. A. Mandrand-Berthelot, J. Bacteriol. 2005, 187, 2912–2916.

    CAS  PubMed Central  PubMed  Google Scholar 

  123. R. Ge, Y. Zhang, X. Sun, R. M. Watt, Q. Y. He, J. D. Huang, D. E. Wilcox, H. Sun, J. Am. Chem. Soc. 2006, 128, 11330–11331.

    CAS  PubMed  Google Scholar 

  124. R. J. Maier, S. L. Benoit, S. Seshadri, BioMetals 2007, 20, 655–664.

    CAS  PubMed Central  PubMed  Google Scholar 

  125. Y. B. Zeng, D. M. Zhang, H. Li, H. Sun, J. Biol. Inorg. Chem. 2008, 13, 1121–1131.

    CAS  PubMed  Google Scholar 

  126. F. Musiani, B. Zambelli, M. Stola, S. Ciurli, J. Inorg. Biochem. 2004, 98, 803–813.

    CAS  PubMed  Google Scholar 

  127. B. Zambelli, F. Musiani, M. Savini, P. Tucker, S. Ciurli, Biochemistry 2007, 46, 3171–3182.

    CAS  PubMed  Google Scholar 

  128. R. Real-Guerra, F. Staniscuaski, B. Zambelli, F. Musiani, S. Ciurli, C. R. Carlini, Plant Mol. Biol. 2012, 78, 461–475.

    CAS  PubMed  Google Scholar 

  129. J. W. Olson, R. J. Maier, J. Bacteriol. 2000, 182, 1702–1705.

    CAS  PubMed Central  PubMed  Google Scholar 

  130. C. Wulfing, J. Lombardero, A. Pluckthun, J. Biol. Chem. 1994, 269, 2895–2901.

    CAS  PubMed  Google Scholar 

  131. R. K. Watt, P. W. Ludden, J. Biol. Chem. 1998, 273, 10019–10025.

    CAS  PubMed  Google Scholar 

  132. H.-K. Song, S. B. Mulrooney, R. Huber, R. P. Hausinger, J. Biol. Chem. 2001, 276, 49359–49364.

    CAS  PubMed  Google Scholar 

  133. H. Remaut, N. Safarov, S. Ciurli, J. Van Beeumen, J. Biol. Chem. 2001, 276, 49365–49370.

    CAS  PubMed  Google Scholar 

  134. K. Banaszak, V. Martin-Diaconescu, M. Bellucci, B. Zambelli, W. Rypniewski, M. J. Maroney, S. Ciurli, Biochem. J. 2012, 441, 1017–1026.

    CAS  PubMed Central  PubMed  Google Scholar 

  135. N. Mehta, J. W. Olson, R. J. Maier, J. Bacteriol. 2003, 185, 726–734.

    CAS  PubMed Central  PubMed  Google Scholar 

  136. H. K. Loke, P. A. Lindahl, J. Inorg. Biochem. 2003, 93, 33–40.

    CAS  PubMed  Google Scholar 

  137. R. L. Kerby, P. W. Ludden, G. P. Roberts, J. Bacteriol. 1997, 179, 2259–2266.

    CAS  PubMed Central  PubMed  Google Scholar 

  138. P. Neyroz, B. Zambelli, S. Ciurli, Biochemistry 2006, 45, 8918–8930.

    CAS  PubMed  Google Scholar 

  139. B. Zambelli, M. Stola, F. Musiani, K. De Vriendt, B. Samyn, B. Devreese, J. Van Beeumen, P. Turano, A. Dikiy, D. A. Bryant, S. Ciurli, J. Biol. Chem. 2005, 280, 4684–4695.

    CAS  PubMed  Google Scholar 

  140. B. Zambelli, P. Turano, F. Musiani, P. Neyroz, S. Ciurli, Proteins 2009, 74, 222–239.

    CAS  PubMed  Google Scholar 

  141. B. Zambelli, N. Cremades, P. Neyroz, P. Turano, V. N. Uversky, S. Ciurli, Mol. Biosyst. 2012, 8, 220–228.

    CAS  PubMed  Google Scholar 

  142. M. Bellucci, B. Zambelli, F. Musiani, P. Turano, S. Ciurli, Biochem. J. 2009, 422, 91–100.

    CAS  PubMed  Google Scholar 

  143. Y. H. Fong, H. C. Wong, C. P. Chuck, Y. W. Chen, H. Sun, K. B. Wong, J. Biol. Chem. 2011, 286, 43241–43249.

    CAS  PubMed Central  PubMed  Google Scholar 

  144. B. Zambelli, F. Musiani, S. Ciurli, Met. Ions Life Sci. 2012, 10, 135–170.

    PubMed  Google Scholar 

  145. Z. Ma, F. E. Jacobsen, D. P. Giedroc, Chem. Rev. 2009, 109, 4644–4681.

    CAS  PubMed Central  PubMed  Google Scholar 

  146. B. Zambelli, M. Bellucci, A. Danielli, V. Scarlato, S. Ciurli, Chem. Commun. 2007, 3649–3651.

    Google Scholar 

  147. B. Zambelli, A. Danielli, S. Romagnoli, P. Neyroz, S. Ciurli, V. Scarlato, J. Mol. Biol. 2008, 383, 1129–1143.

    CAS  PubMed  Google Scholar 

  148. F. Musiani, B. Bertosa, A. Magistrato, B. Zambelli, P. Turano, V. Losasso, C. Micheletti, S. Ciurli, P. Carloni, J. Chem. Theor. Comp. 2010, 6, 3503–3515.

    CAS  Google Scholar 

  149. S. Benini, M. Cianci, S. Ciurli, Dalton Trans. 2011, 40, 7831–7833.

    CAS  PubMed  Google Scholar 

  150. J. G. Kusters, A. H. van Vliet, E. J. Kuipers, Clin. Microbiol. Rev. 2006, 19, 449–490.

    CAS  PubMed Central  PubMed  Google Scholar 

  151. H. de Reuse, S. Bereswill, FEMS Immunol. Med. Microbiol. 2007, 50, 165–176.

    PubMed  Google Scholar 

  152. A. Danielli, G. Amore, V. Scarlato, PLoS Pathog. 2010, 6, e1000938. DOI: 10.371/journal.ppat.1000938.

    PubMed Central  PubMed  Google Scholar 

  153. K. A. Eaton, S. Krakowka, Infect. Immun. 1994, 62, 3604–3607.

    CAS  PubMed Central  PubMed  Google Scholar 

  154. K. Muhsen, D. Cohen, Helicobacter 2008, 13, 323–340.

    CAS  PubMed  Google Scholar 

  155. S. L. Benoit, E. F. Miller, R. J. Maier, Infect. Immun. 2013, 81, 580–584.

    CAS  PubMed Central  PubMed  Google Scholar 

  156. M. Sousa Silva, A. E. Ferreira, R. Gomes, A. M. Tomas, A. Ponces Freire, C. Cordeiro, Int. J. Med. Microbiol. 2012, 302, 225–229.

    CAS  PubMed  Google Scholar 

  157. S. C. Chauhan, P. K. Padmanabhan, R. Madhubala, Curr. Drug Targets 2008, 9, 957–965.

    CAS  PubMed  Google Scholar 

  158. WHO, "Global tuberculosis control report 2011", World Health Organization, Geneva, Switzerland, 2011.

    Google Scholar 

  159. W. Lin, V. Mathys, E. L. Ang, V. H. Koh, J. M. Martinez Gomez, M. L. Ang, S. Z. Zainul Rahim, M. P. Tan, K. Pethe, S. Alonso, Infect. Immun. 2012, 80, 2771–2779.

    CAS  PubMed Central  PubMed  Google Scholar 

  160. D. L. Clemens, B. Y. Lee, M. A. Horwitz, J. Bacteriol. 1995, 177, 5644–5652.

    CAS  PubMed Central  PubMed  Google Scholar 

  161. A. H. Gordon, P. D. Hart, M. R. Young, Nature 1980, 286, 79–80.

    CAS  PubMed  Google Scholar 

  162. P. D. Hart, M. R. Young, J. Exp. Med. 1991, 174, 881–889.

    CAS  PubMed  Google Scholar 

  163. K. Sendide, A. E. Deghmane, J. M. Reyrat, A. Talal, Z. Hmama, Infect. Immun. 2004, 72, 4200–4209.

    CAS  PubMed Central  PubMed  Google Scholar 

  164. T. Mukai, Y. Maeda, T. Tamura, Y. Miyamoto, M. Makino, FEMS Immunol. Med. Microbiol. 2008, 53, 96–106.

    CAS  PubMed  Google Scholar 

  165. L. Grode, P. Seiler, S. Baumann, J. Hess, V. Brinkmann, A. Nasser Eddine, P. Mann, C. Goosmann, S. Bandermann, D. Smith, G. J. Bancroft, J. M. Reyrat, D. van Soolingen, B. Raupach, S. H. Kaufmann, J. Clin. Invest. 2005, 115, 2472–2479.

    CAS  PubMed Central  PubMed  Google Scholar 

  166. D. R. Campbell, K. E. Chapman, K. J. Waldron, S. Tottey, S. Kendall, G. Cavallaro, C. Andreini, J. Hinds, N. G. Stoker, N. J. Robinson, J. S. Cavet, J. Biol. Chem. 2007, 282, 32298–32310.

    CAS  PubMed Central  PubMed  Google Scholar 

  167. A. Schnegg, M. Kirchgessner, in In Trace Element Metabolism in Man and Animals-3, Ed M. Kirchgessner, Proceedings of the 3rd Intern. Symposium, Technische Universität, Munchen, Germany, 1978, pp. 236–243.

    Google Scholar 

  168. F. H. Nielsen, D. R. Myron, S. H. Givand, T. J. Zimmerman, D. A. Ollerich, J. Nutr. 1975, 105, 1620–1630.

    CAS  PubMed  Google Scholar 

  169. M. Szilagyi, M. Anke, I. Balogh, Acta Vet. Hung. 1991, 39, 231–238.

    CAS  PubMed  Google Scholar 

  170. K. Yokoi, E. O. Uthus, F. H. Nielsen, Biol. Trace Elem. Res. 2003, 93, 141–154.

    CAS  PubMed  Google Scholar 

  171. F. H. Nielsen, T. R. Shuler, T. G. McLeod, T. J. Zimmerman, J. Nutr. 1984, 114, 1280–1288.

    CAS  PubMed  Google Scholar 

  172. J. W. Spears, R. W. Harvey, L. J. Samsell, J. Nutr. 1986, 116, 1873–1882.

    CAS  PubMed  Google Scholar 

  173. G. I. Stangl, M. Kirchgessner, J. Nutr. 1996, 126, 2466–2473.

    CAS  PubMed  Google Scholar 

  174. V. Tremaroli, F. Backhed, Nature 2012, 489, 242–249.

    CAS  PubMed  Google Scholar 

  175. C. Palmer, E. M. Bik, D. B. DiGiulio, D. A. Relman, P. O. Brown, PLoS Biol. 2007, 5, e177.

    PubMed Central  PubMed  Google Scholar 

  176. P. B. Eckburg, E. M. Bik, C. N. Bernstein, E. Purdom, L. Dethlefsen, M. Sargent, S. R. Gill, K. E. Nelson, D. A. Relman, Science 2005, 308, 1635–1638.

    PubMed Central  PubMed  Google Scholar 

  177. M. Monachese, J. P. Burton, G. Reid, Appl. Environ. Microbiol. 2012, 78, 6397–6404.

    CAS  PubMed Central  PubMed  Google Scholar 

  178. K. Suzuki, Y. Benno, T. Mitsuoka, S. Takebe, K. Kobashi, J. Hase, Appl. Environ. Microbiol. 1979, 37, 379–382.

    CAS  PubMed Central  PubMed  Google Scholar 

  179. F. Turroni, E. Foroni, P. Pizzetti, V. Giubellini, A. Ribbera, P. Merusi, P. Cagnasso, B. Bizzarri, G. L. de’Angelis, F. Shanahan, D. van Sinderen, M. Ventura, Appl. Environ. Microbiol. 2009, 75, 1534–1545.

    Google Scholar 

  180. I. S. Arvanitoyannis, M. Van Houwelingen-Koukaliaroglou, Crit. Rev. Food Sci. Nutr. 2005, 45, 385–404.

    PubMed  Google Scholar 

  181. M. Pimentel, R. P. Gunsalus, S. S. Rao, H. Zhang, Am. J. Gastroenter. Suppl. 2012, 1, 28–33.

    Google Scholar 

  182. B. Jaun, R. K. Thauer, in Nickel and Its Surprising Impact in Nature, Vol. 2 of Metal Ions in Life Sciences, Eds A. Sigel, H. Sigel, R. K. O Sigel, John Wiley & Sons, Ltd., Chichester, UK, 2007, pp. 323–356.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Bioinorganic Chemistry, Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy

    Barbara Zambelli & Stefano Ciurli

Authors
  1. Barbara Zambelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stefano Ciurli
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stefano Ciurli .

Editor information

Editors and Affiliations

  1. Dept. of Chemistry, Inorganic Chemistry, University of Basel, Basel, Basel Stadt, Switzerland

    Astrid Sigel

  2. Department of Chemistry, Inorganic Chemistry, University of Basel, Basel, Switzerland

    Helmut Sigel

  3. Institute of Inorganic Chemistry, University of Zürich, Zürich, Zürich, Switzerland

    Roland K.O. Sigel

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Zambelli, B., Ciurli, S. (2013). Nickel and Human Health. In: Sigel, A., Sigel, H., Sigel, R. (eds) Interrelations between Essential Metal Ions and Human Diseases. Metal Ions in Life Sciences, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7500-8_10

Download citation

Publish with us

Policies and ethics