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Magnesium in Health and Disease

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Interrelations between Essential Metal Ions and Human Diseases

Part of the book series: Metal Ions in Life Sciences ((MILS,volume 13))

Abstract

Mammalian cells tightly regulate cellular Mg2+ content through a variety of transport and buffering mechanisms under the control of various hormones and cellular second messengers. The effect of these hormones and agents results in dynamic changes in the total content of Mg2+ being transported across the cell membrane and redistributed within cellular compartments. The importance of maintaining proper cellular Mg2+ content optimal for the activity of various cellular enzymes and metabolic cycles is underscored by the evidence that several diseases are characterized by a loss of Mg2+ within specific tissues as a result of defective transport, hormonal stimulation, or metabolic impairment. This chapter will review the key mechanisms regulating cellular Mg2+ homeostasis and their impairments under the most common diseases associated with Mg2+ loss or deficiency.

Please cite as: Met. Ions Life Sci. 13 (2013) 49–79

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Acknowledgements

 This work was supported by NIAAA-11593 and in part by NIH-HL090969.

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  1. Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106-4970, USA

    Andrea M. P. Romani

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  1. Dept. of Chemistry, Inorganic Chemistry, University of Basel, Basel, Basel Stadt, Switzerland

    Astrid Sigel

  2. Department of Chemistry, Inorganic Chemistry, University of Basel, Basel, Switzerland

    Helmut Sigel

  3. Institute of Inorganic Chemistry, University of Zürich, Zürich, Zürich, Switzerland

    Roland K.O. Sigel

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Romani, A.M.P. (2013). Magnesium in Health and Disease. In: Sigel, A., Sigel, H., Sigel, R. (eds) Interrelations between Essential Metal Ions and Human Diseases. Metal Ions in Life Sciences, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7500-8_3

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