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Serum adiponectin and markers of endothelial injury in hemodialysis patients with arteriosclerosis obliterans

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Abstract

Background

Arteriosclerosis obliterans (ASO) in hemodialysis patients is the dominant cause of morbidity evolving from arteriosclerosis. Adiponectin is an adipose-derived cytokine which, because of its modulation of endothelial adhesion molecules, has potential anti-inflammatory and anti-atherogenic properties. However, the implications of adiponectin and endothelial function in ASO of hemodialysis patients has not been fully elucidated.

Methods

In this study we measured serum levels of adiponectin, adhesion molecules (VCAM-1 and ICAM-1), and an endothelial cell injury marker (CD146) in patients with ASO. We sought to determine clinical and laboratory correlates of ASO in ESRD patients. A total of 80 hemodialysis patients and 82 patients with normal serum creatinine levels were enrolled. Serum levels of adiponectin, ICAM-1, VCAM-1, and CD146 were measured by ELISA.

Results

Serum adiponectin levels in 41 hemodialysis patients with ASO were significantly lower than in 39 patients without ASO. Serum CD146 levels in hemodialysis patients with ASO were significantly higher than in patients without ASO. There were no significant differences between levels of ICAM-1 and VCAM-1 in these two groups. Similar results were obtained for patients with normal renal function. Serum adiponectin was related to hemodialysis duration and BMI in hemodialysis patients. In patients with normal renal function, adiponectin was related to HDL-cholesterol, triglyceride, and ICAM-1.

Conclusion

A decrease in serum adiponectin levels and an increase in serum CD146 may be closely associated with the development of ASO, regardless of renal function. However, there are different mechanisms determining serum adiponectin levels in patients with normal kidney function and in hemodialysis patients.

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Acknowledgments

This study was supported by grants from the Ministry of Education, Science and Culture of Japan (No. 16590798).

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Authors and Affiliations

  1. Department of Nephrology, Jichi Medical University, Simotsuke, Tochigi, 329-0498, Japan

    Osamu Saito, Takako Saito, Kousuke Okuda, Atsushi Kotoda, Tetsu Akimoto, Yasuhiro Ando, Shigeaki Muto & Eiji Kusano

  2. Department of Medicine, Jichi Medical University Saitama Medical Center, Saitama, 330-8503, Japan

    San-e Ishikawa

  3. Okuda-Clinic, Tochigi, 321-0964, Japan

    Kousuke Okuda & Kenji Okuda

Authors
  1. Osamu Saito
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  2. Takako Saito
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  3. Kousuke Okuda
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Corresponding author

Correspondence to Osamu Saito.

Additional information

In memory of Dr Kenji Okuda (1944–2007).

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Saito, O., Saito, T., Okuda, K. et al. Serum adiponectin and markers of endothelial injury in hemodialysis patients with arteriosclerosis obliterans. Clin Exp Nephrol 12, 58–64 (2008). https://doi.org/10.1007/s10157-007-0012-7

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  • DOI: https://doi.org/10.1007/s10157-007-0012-7

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