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Loss of angiotensin-converting enzyme 2 leads to impaired glucose homeostasis in mice

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Abstract

This study aimed to investigate the role of angiotensin-converting enzyme 2 (ACE2) in regulating glucose homeostasis. Immunohistochemistry was used to investigate ACE2 expression in the pancreas. Glucose tolerance test, insulin secretion test, and insulin tolerance test were performed in age-matched male ACE2 knockout (KO) and wild-type (WT) mice. We found that ACE2 was positively expressed in the pancreas. Male ACE2 KO mice displayed a selective decrease in first-phase insulin secretion in response to glucose and a progressive impairment of glucose tolerance compared with age- and sex-matched WT mice. On the other hand, insulin sensitivity of the peripheral tissue in age-matched ACE2 KO and WT mice showed no difference. These findings suggest that ACE2 might play an important role in glucose homeostasis as well as type 2 diabetes.

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Acknowledgment

This study was supported by the National Natural Science Foundation of China (No. 30671001) and 973 program (No. 2006CB503909).

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Authors and Affiliations

  1. Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China

    Ming-Jia Niu, Jin-Kui Yang, Shan-Shan Lin, Xiu-Juan Ji & Li-Min Guo

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Correspondence to Jin-Kui Yang.

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Niu, MJ., Yang, JK., Lin, SS. et al. Loss of angiotensin-converting enzyme 2 leads to impaired glucose homeostasis in mice. Endocr 34, 56–61 (2008). https://doi.org/10.1007/s12020-008-9110-x

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