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Regulation of Voltage-Gated Calcium Channels by Synaptic Proteins

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Calcium Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 740))

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Abstract

Calcium entry through neuronal voltage-gated calcium channels into presynaptic nerve terminal is a key step in synaptic exocytosis. In order to receive the calcium signal and trigger fast, efficient and spatially delimited neurotransmitter release, the vesicle-docking/release machinery must be located near the calcium source. In many cases, this close localization is achieved by a direct interaction of several members of the vesicle release machinery with the calcium channels. In turn, the binding of synaptic proteins to presynaptic calcium channels modulates channel activity to provide fine control over calcium entry, and thus modulates synaptic strength. In this chapter we summarize our present knowledge of the molecular mechanisms by which synaptic proteins regulate presynaptic calcium channel activity.

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Acknowledgments

Norbert Weiss is supported by fellowships from Alberta Heritage Foundation for Medical Research (AHFMR) and from Hotchkiss Brain Institute. Gerald W. Zamponi is funded by the Canadian Institutes of Health Research, is a Canada Research Chair and Scientist of the Alberta Heritage Foundation for Medical Research.

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  1. Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Dr. NW, T2N 4N1, Calgary, AB, Canada

    Norbert Weiss & Gerald W. Zamponi

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  1. Norbert Weiss
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  2. Gerald W. Zamponi
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Correspondence to Norbert Weiss .

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  1. , Department of Clinical Sciences and Educ, Karolinska Institutet, Tulegatan 26, Stockholm, SE-118 83, Sweden

    Md. Shahidul Islam

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Weiss, N., Zamponi, G.W. (2012). Regulation of Voltage-Gated Calcium Channels by Synaptic Proteins. In: Islam, M. (eds) Calcium Signaling. Advances in Experimental Medicine and Biology, vol 740. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2888-2_33

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