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The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

Nature volume 366, pages 129–135 (1993)Cite this article

Abstract

We have produced a cell line which lacks the protein tyrosine kinase JAK1 and is completely defective in interferon response. Complementation of this mutant with JAK1 restored the response, establishing the requirement for JAK1 in both the interferon-α/β and -γ signal transduction pathways. The reciprocal interdependence between JAK1 and Tyk2 activities in the interferon-α pathway, and between JAK1 and JAK2 in the interferon-γ pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes.

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References

  1. De Maeyer, E. & De Maeyer-Guignard, J. Interferons and Other Regulatory Cytokines (Wiley, New York, 1988).

    Google Scholar 

  2. Pestka, S., Langer, T. A., Zoon, K. C. & Samuel, C. E. Rev. Biochem. 56, 727–777 (1987).

    Article  CAS  Google Scholar 

  3. Pellegrini, S. & Schindler, C. Trends Biochem. Sci. 18, 338–342 (1993).

    Article  CAS  Google Scholar 

  4. Fu, X.-F., Schindler, C., Improta, T., Aebersold, R. & Darnell, J. E. Jr Proc. natn. Acad. Sci. U.S.A. 89, 7840–7843 (1992).

    Article  ADS  CAS  Google Scholar 

  5. Gutch, M. J., Daly, C. & Reich, N. Proc. natn. Acad. Sci. U.S.A. 89, 11411–11415 (1992).

    Article  ADS  CAS  Google Scholar 

  6. Schindler, C., Fu, X.-Y., Improta, T., Aebersold, R. & Darnell, J. E. Jr Proc. natn. Acad. Sci. U.S.A. 89, 7836–7839 (1992).

    Article  ADS  CAS  Google Scholar 

  7. Schindler, C., Shuai, K., Prezioso, V. R. & Darnell, J. E. Jr Science 257, 809–813 (1992).

    Article  ADS  CAS  Google Scholar 

  8. Veals, S. A. et al. Molec. cell. Biol. 12, 3315–3324 (1992).

    Article  CAS  Google Scholar 

  9. Veals, S. A., Santa Maria, T. & Levy, D. E. Molec. cell. Biol. 13, 196–206 (1993).

    Article  CAS  Google Scholar 

  10. Dale, T. C., Imam, A. M. A., Kerr, I. M. & Stark, G. R. Proc. natn. Acad. Sci. U.S.A. 86, 1203–1207 (1989).

    Article  ADS  CAS  Google Scholar 

  11. Kessler, D. S., Veals, S. A., Fu, X.-Y. & Levy, D. E. Genes Dev. 4, 1753–1755 (1990).

    Article  CAS  Google Scholar 

  12. Levy, D. E., Kessler, D. S., Pine, R. & Darnell, J. E. Jr Genes Dev. 3, 1362–1371 (1989).

    Article  CAS  Google Scholar 

  13. Shuai, K., Schindler, C., Prezioso, V. R. & Darnell, J. E. Jr Science 258, 1808–1812 (1992).

    Article  ADS  CAS  Google Scholar 

  14. Müller, M. et al. EMBO J. 12, 4221–4228 (1993).

    Article  Google Scholar 

  15. Decker, T., Lew, D. J., Mirkovitch, J. & Darnell, J. E. Jr EMB0 J. 10, 927–932 (1991).

    Article  CAS  Google Scholar 

  16. Lew, D. J., Decker, T., Strehlow, I. & Darnell, J. E. Jr Molec. cell. Biol. 11, 182–191 (1991).

    Article  CAS  Google Scholar 

  17. Kanno, Y. et al. Molec. cell. Biol. 13, 3951–3963 (1993).

    Article  CAS  Google Scholar 

  18. Khan, K. D. et al. Proc. natn. Acad. Sci. U.S.A. 90, 6806–6810 (1993).

    Article  ADS  CAS  Google Scholar 

  19. Pearse, R. N., Feinman, R., Shuai, K., Darnell, J. E. Jr & Ravetch, J. V. Proc. natn. Acad. Sci. U.S.A. 90, 4314–4318 (1993).

    Article  ADS  CAS  Google Scholar 

  20. Perez, C., Wietzerbin, J. & Benech, P. D. Molec. cell. Biol. 13, 2182–2192 (1993).

    Article  CAS  Google Scholar 

  21. Aguet, M., Dembic, Z. & Merlin, G. Cell 55, 273–280 (1988).

    Article  CAS  Google Scholar 

  22. Uzé, G., Lutfalla, G. & Gresser, I. Cell 60, 225–235 (1990).

    Article  Google Scholar 

  23. Platanias, L. C. & Colamonici, O. R. J. biol. Chem. 267, 24053–24057 (1992).

    CAS  PubMed  Google Scholar 

  24. Cook, J. R., Jung, V., Schwartz, B., Wang, P. & Pestka. S. Proc. natn. Acad. Sci. U.S.A. 89, 11317–11321 (1992).

    Article  ADS  CAS  Google Scholar 

  25. Farrar, M. A., Campbell, J. D. & Schreiber, R. D. Proc. natn. Acad. Sci. U.S.A. 89, 11706–11710 (1992).

    Article  ADS  CAS  Google Scholar 

  26. Wilks, A. F. Proc. natn. Acad. Sci. U.S.A. 86, 1603–1607 (1989).

    Article  ADS  CAS  Google Scholar 

  27. Wilks, A. F. et al. Molec. cell. Biol. 11, 2057–2065 (1991).

    Article  CAS  Google Scholar 

  28. Harpur, A. G., Andrew, A.-C., Ziemiecki, A., Aston, R. R. & Wilks, A. F. Oncogene 7, 1347–1353 (1992).

    CAS  PubMed  Google Scholar 

  29. Howard, O. M. Z. et al. Oncogene 7, 895–900 (1992).

    CAS  PubMed  Google Scholar 

  30. Silvennoinen, O. et al. Proc. natn. Acad. Sci. U.S.A. 90, 8429–8433 (1993).

    Article  ADS  CAS  Google Scholar 

  31. Firmbach-Kraft, I., Byers, M., Shows, T., Dalla-Favera, R. & Krolewski, J. J. Oncogene, 5, 1329–1336 (1990).

    CAS  PubMed  Google Scholar 

  32. Velazquez, L., Fellous, M., Stark, G. R. & Pellegrini, S. Cell 70, 313–322 (1992).

    Article  CAS  Google Scholar 

  33. Pellegrini, S., John, J., Shearer, M., Kerr, I. M. & Stark, G. R. Molec. cell Biol. 9, 4605–4612 (1989).

    Article  CAS  Google Scholar 

  34. McKendry, R. et al. Proc. natn. Acad. Sci. U.S.A. 88, 11455–11459 (1991).

    Article  ADS  CAS  Google Scholar 

  35. Pine, R., Decker, T., Kessler, D. S., Levy, D. E. & Darnell, J. E. Jr Molec. cell. Biol. 10, 2448–2457 (1990).

    Article  CAS  Google Scholar 

  36. Sims, S. H. et al. Molec. cell. Biol. 13, 690–702 (1993).

    Article  CAS  Google Scholar 

  37. Bolen, J. B. Oncogene 8, 2025–2031 (1993).

    CAS  PubMed  Google Scholar 

  38. Argetsinger, L. S. et al. Cell 74, 237–244 (1993).

    Article  CAS  Google Scholar 

  39. Witthuhn, B. A. et al. Cell 74, 227–236 (1993).

    Article  CAS  Google Scholar 

  40. Beyers, A. D., Spruyt, L. L. & Williams, A. F. Trends Cell Biol. 2, 253–255 (1992).

    Article  CAS  Google Scholar 

  41. Weiss, A. Cell 73, 209–212 (1993).

    Article  CAS  Google Scholar 

  42. David, M., Romero, G., Zhang, Z.-Y., Dixon, J. E. & Larner, A. C. J. biol. Chem. 268, 6593–6599 (1993).

    CAS  PubMed  Google Scholar 

  43. Levy, D. E. & Darnell, J. E. Jr New Biol. 2, 923–928 (1990).

    CAS  PubMed  Google Scholar 

  44. Stahl, N. & Yancopoulos, G. D. Cell 74, 587–590 (1993).

    Article  CAS  Google Scholar 

  45. Larner, A. C. et al. Science 261, 1730–1733 (1993).

    Article  ADS  CAS  Google Scholar 

  46. Ruff-Jamison, S., Chen, K. & Cohen, S. Science 261, 1733–1736 (1993).

    Article  ADS  CAS  Google Scholar 

  47. Silvennoinen, O., Schindler, C., Schlessinger, J. & Levy, D. E. Science 261, 1736–1739 (1993).

    Article  ADS  CAS  Google Scholar 

  48. Sadowski, H. B., Shuai, K., Darnell, J. E. Jr & Gilman, M. Z. Science 261, 1739–1744 (1993).

    Article  ADS  CAS  Google Scholar 

  49. Seed, B. Nature 329, 840–842 (1987).

    Article  ADS  CAS  Google Scholar 

  50. Claesson, L., Larhammar, D., Rask, L. & Peterson, P. A. Proc. natn. Acad. Sci. U.SA. 80, 7395–7399 (1983).

    Article  ADS  CAS  Google Scholar 

  51. Watling, D. et al. Nature 366, 166–170 (1993).

    Article  ADS  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Imperial Cancer Research Fund Laboratories, PO Box 123, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK

    Mathias Müller, James Briscoe, Carl Laxton, Dmitry Guschin & lan M. Kerr

  2. Institute for Clinical and Experimental Cancer Research, University of Berne, Tiefenaustrasse 120, 3004, Berne, Switzerland

    Andrew Ziemiecki

  3. Pharmacology, New York University Medical Center, New York, New York, 10016, USA

    Olli Silvennoinen

  4. Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, Victoria, 3050, Australia

    Ailsa G. Harpur & Andrew F. Wilks

  5. Unité INSERM 276, Institut Pasteur, 75724, Paris, Cedex 15, France

    Giovanna Barbieri & Sandra Pellegrini

  6. Biochemistry, St Jude Children's Research Hospital, 322 North Lauderdale, Memphis, Tennesee, 38101-0318, USA

    Bruce A. Witthuhn & James N. Ihle

  7. Department of Medicine, Columbia University Medical Center, New York, New York, 10032, USA

    Chris Schindler

  8. Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, 44195, USA

    George R. Stark

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  1. Mathias Müller
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Müller, M., Briscoe, J., Laxton, C. et al. The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction. Nature 366, 129–135 (1993). https://doi.org/10.1038/366129a0

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