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Characterization of a New Member of the TNF Family Expressed on Antigen Presenting Cells

  • Catherine Tribouley , Marco Wallroth , Vivien Chan , Xavier Paliard , Eric Fang , George Lamson , David Pot , Jaime Escobedo and Lewis T. Williams
Published/Copyright: June 1, 2005
Biological Chemistry
From the journal Volume 380 Issue 12

Abstract

The TNF family is involved in the regulation of the immune system, and its members have been implicated in a variety of biological events such as apoptosis, cell proliferation, differentiation and survival. Here we present a new member of the TNF family, tumor necrosis factor super family member 20 (TNFSF20) that we have identified from the expressed sequence tag (EST) database and characterized. The human protein is a 285 amino acid long type II transmembrane protein and is 19% homologous to TNF in its extra-cellular domain. TNFSF20 is expressed at the surface of antigen presenting cells such as cells of the macrophagemonocyte lineage and dendritic cells. After treatment with bacterial lipopolysaccharide (LPS), TNFSF20 expression is downregulated at the surface of the expresssing cells, suggesting that the membrane-bound protein gets cleaved, and that a soluble factor is released in the extra-cellular compartment. The soluble form of the recombinant TNFSF20 induces proliferation of resting peripheral blood monocytes (PBMC) and cell death of activated lymphocytes. TNFSF20 might therefore play a critical role in the regulation of cell-mediated immune responses.

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Published Online: 2005-06-01
Published in Print: 1999-12-20

Copyright © 1999 by Walter de Gruyter GmbH & Co. KG

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  1. To Our Authors, Readers and Subscribers
  2. Editor's Note
  3. A Chimpanzee Millennium
  4. Molecular Genetics of Dopa-Responsive Dystonia
  5. In Vitro Transcription of a TATA-Less Promoter: Negative Regulation by the Not1 Protein
  6. Fast Control of DNA Replication in Response to Hypoxia and to Inhibited Protein Synthesis in CCRF-CEM and HeLa Cells
  7. The Inhibition of NF-B Activation Pathways and the Induction of Apoptosis by Dithiocarbamates in T Cells Are Blocked by the Glutathione Precursor N-Acetyl-L-Cysteine
  8. Xylose Utilisation: Cloning and Characterisation of the Xylose Reductase from Candida tenuis
  9. Xylose Utilisation: Cloning and Characterisation of the Xylitol Dehydrogenase from Galactocandida mastotermitis
  10. Thermodynamic Properties and DNA Binding of the ParD Protein from the Broad Host-Range Plasmid RK2/RP4 Killing System
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  12. Genomic Expansion Across the Albumin Gene Family on Human Chromosome 4q Is Directional
  13. Comparison of the Tamoxifen Regulated Chimeric Cre Recombinases MerCreMer and CreMer
  14. The Human Cathepsin F Gene a Fusion Product between an Ancestral Cathepsin and Cystatin Gene
  15. Characterization of a New Member of the TNF Family Expressed on Antigen Presenting Cells
  16. Vascular Endothelial Growth Factor (VEGF) and Its Receptors in Tumor-Bearing Dogs
  17. Molecular Cloning and Characterization of a cDNA Encoding a Transferrin Homolog from Bombyx mori
  18. Mitochondria-Derived and Extra-Mitochondrial Human Type-1 Porin Are Identical as Revealed by Amino Acid Sequencing and Electrophysiological Characterisation
  19. Acknowledgement
  20. Content Index
  21. Author Index
  22. Subject Index
https://doi.org/10.1515/BC.1999.186

Articles in the same Issue

  1. To Our Authors, Readers and Subscribers
  2. Editor's Note
  3. A Chimpanzee Millennium
  4. Molecular Genetics of Dopa-Responsive Dystonia
  5. In Vitro Transcription of a TATA-Less Promoter: Negative Regulation by the Not1 Protein
  6. Fast Control of DNA Replication in Response to Hypoxia and to Inhibited Protein Synthesis in CCRF-CEM and HeLa Cells
  7. The Inhibition of NF-B Activation Pathways and the Induction of Apoptosis by Dithiocarbamates in T Cells Are Blocked by the Glutathione Precursor N-Acetyl-L-Cysteine
  8. Xylose Utilisation: Cloning and Characterisation of the Xylose Reductase from Candida tenuis
  9. Xylose Utilisation: Cloning and Characterisation of the Xylitol Dehydrogenase from Galactocandida mastotermitis
  10. Thermodynamic Properties and DNA Binding of the ParD Protein from the Broad Host-Range Plasmid RK2/RP4 Killing System
  11. Dipeptidyl Peptidase III from Rat Liver Cytosol: Purification, Molecular Cloning and Immunohistochemical Localization
  12. Genomic Expansion Across the Albumin Gene Family on Human Chromosome 4q Is Directional
  13. Comparison of the Tamoxifen Regulated Chimeric Cre Recombinases MerCreMer and CreMer
  14. The Human Cathepsin F Gene a Fusion Product between an Ancestral Cathepsin and Cystatin Gene
  15. Characterization of a New Member of the TNF Family Expressed on Antigen Presenting Cells
  16. Vascular Endothelial Growth Factor (VEGF) and Its Receptors in Tumor-Bearing Dogs
  17. Molecular Cloning and Characterization of a cDNA Encoding a Transferrin Homolog from Bombyx mori
  18. Mitochondria-Derived and Extra-Mitochondrial Human Type-1 Porin Are Identical as Revealed by Amino Acid Sequencing and Electrophysiological Characterisation
  19. Acknowledgement
  20. Content Index
  21. Author Index
  22. Subject Index
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