Review
doi: 10.1016/s1074-5521(99)80058-1.
Hydrogen tunneling in biology
Affiliations
- PMID: 10381408
- DOI: 10.1016/s1074-5521(99)80058-1
Item in Clipboard
Review
Hydrogen tunneling in biology
Chem Biol.
1999 Jul.
Abstract
The mechanistic details of hydrogen transfer in biological systems are not fully understood. The traditional approach has been to use semiclassical transition-state theory. This theory cannot explain many experimental findings, however, so different approaches that emphasize the importance of quantum mechanics and dynamic effects should also be considered.
Similar articles
-
Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics.Eur J Biochem. 2002 Jul;269(13):3113-21. doi: 10.1046/j.1432-1033.2002.03022.x. Eur J Biochem. 2002. PMID: 12084051 Review.
-
Quantum mechanics/molecular mechanics studies of triosephosphate isomerase-catalyzed reactions: effect of geometry and tunneling on proton-transfer rate constants.J Am Chem Soc. 2002 Mar 27;124(12):3093-124. doi: 10.1021/ja0118439. J Am Chem Soc. 2002. PMID: 11902900
-
Coupling of hydrogenic tunneling to active-site motion in the hydrogen radical transfer catalyzed by a coenzyme B12-dependent mutase.Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10774-9. doi: 10.1073/pnas.0702188104. Epub 2007 Jun 20. Proc Natl Acad Sci U S A. 2007. PMID: 17581872 Free PMC article.
-
Boundary conditions for the Swain-Schaad relationship as a criterion for hydrogen tunneling.J Am Chem Soc. 2002 Apr 17;124(15):3858-64. doi: 10.1021/ja016909e. J Am Chem Soc. 2002. PMID: 11942822
-
Understanding Biological Hydrogen Transfer Through the Lens of Temperature Dependent Kinetic Isotope Effects.Acc Chem Res. 2018 Sep 18;51(9):1966-1974. doi: 10.1021/acs.accounts.8b00226. Epub 2018 Aug 28. Acc Chem Res. 2018. PMID: 30152685 Free PMC article. Review.
Cited by
-
Hydrogen tunneling links protein dynamics to enzyme catalysis.Annu Rev Biochem. 2013;82:471-96. doi: 10.1146/annurev-biochem-051710-133623. Annu Rev Biochem. 2013. PMID: 23746260 Free PMC article. Review.
-
Mechanism of the Swern oxidation: significant deviations from transition state theory.J Org Chem. 2010 Dec 3;75(23):8088-99. doi: 10.1021/jo101636w. Epub 2010 Nov 2. J Org Chem. 2010. PMID: 21043525 Free PMC article.
-
Effects of isoleucine 135 side chain length on the cofactor donor-acceptor distance within F420H2:NADP+ oxidoreductase: A kinetic analysis.Biochem Biophys Rep. 2016 Nov 30;9:114-120. doi: 10.1016/j.bbrep.2016.11.012. eCollection 2017 Mar. Biochem Biophys Rep. 2016. PMID: 28955995 Free PMC article.
-
Coupling of protein motions and hydrogen transfer during catalysis by Escherichia coli dihydrofolate reductase.Biochem J. 2006 Feb 15;394(Pt 1):259-65. doi: 10.1042/BJ20051464. Biochem J. 2006. PMID: 16241906 Free PMC article.
-
Comparison of enzymatic and non-enzymatic nitroethane anion formation: thermodynamics and contribution of tunneling.J Am Chem Soc. 2004 May 26;126(20):6244-5. doi: 10.1021/ja0484606. J Am Chem Soc. 2004. PMID: 15149217 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
