ACEing COVID-19: A Role for Angiotensin Axis Inhibition in SARS-CoV-2 Infection?

doi:10.1161/CIRCRESAHA.120.317174

Editorial

. 2020 Jun 5;126(12):1682-1684.

doi: 10.1161/CIRCRESAHA.120.317174. Epub 2020 Apr 17.

ACEing COVID-19: A Role for Angiotensin Axis Inhibition in SARS-CoV-2 Infection?

Venkatesh L Murthy¹, Milka Koupenova², Ravi V Shah³

Affiliations

¹ From the Department of Medicine and Radiology, University of Michigan, Ann Arbor (V.L.M.).
² Department of Medicine, University of Massachusetts Medical School, Worcester (M.K.).
³ Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (R.V.S.).

PMID: 32302248
PMCID: PMC7274880
DOI: 10.1161/CIRCRESAHA.120.317174

Editorial

ACEing COVID-19: A Role for Angiotensin Axis Inhibition in SARS-CoV-2 Infection?

Venkatesh L Murthy et al. Circ Res. 2020.

. 2020 Jun 5;126(12):1682-1684.

doi: 10.1161/CIRCRESAHA.120.317174. Epub 2020 Apr 17.

Authors

Venkatesh L Murthy¹, Milka Koupenova², Ravi V Shah³

Affiliations

¹ From the Department of Medicine and Radiology, University of Michigan, Ann Arbor (V.L.M.).
² Department of Medicine, University of Massachusetts Medical School, Worcester (M.K.).
³ Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston (R.V.S.).

PMID: 32302248
PMCID: PMC7274880
DOI: 10.1161/CIRCRESAHA.120.317174

No abstract available

Keywords: COVID-19; Editorials; angiotensin II; hypertension; infections.

PubMed Disclaimer

Comment on

Association of Inpatient Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Mortality Among Patients With Hypertension Hospitalized With COVID-19.
Zhang P, Zhu L, Cai J, Lei F, Qin JJ, Xie J, Liu YM, Zhao YC, Huang X, Lin L, Xia M, Chen MM, Cheng X, Zhang X, Guo D, Peng Y, Ji YX, Chen J, She ZG, Wang Y, Xu Q, Tan R, Wang H, Lin J, Luo P, Fu S, Cai H, Ye P, Xiao B, Mao W, Liu L, Yan Y, Liu M, Chen M, Zhang XJ, Wang X, Touyz RM, Xia J, Zhang BH, Huang X, Yuan Y, Loomba R, Liu PP, Li H. Zhang P, et al. Circ Res. 2020 Jun 5;126(12):1671-1681. doi: 10.1161/CIRCRESAHA.120.317134. Epub 2020 Apr 17. Circ Res. 2020. PMID: 32302265 Free PMC article.

Cited by

Navigating migraine care through the COVID-19 pandemic: an update.
Angus-Leppan H, Guiloff AE, Benson K, Guiloff RJ. Angus-Leppan H, et al. J Neurol. 2021 Nov;268(11):4388-4395. doi: 10.1007/s00415-021-10610-w. Epub 2021 May 17. J Neurol. 2021. PMID: 34002281 Free PMC article.
Association between renin-angiotensin-aldosterone system inhibitor use and COVID-19 hospitalization and death: a 1.4 million patient nationwide registry analysis.
Savarese G, Benson L, Sundström J, Lund LH. Savarese G, et al. Eur J Heart Fail. 2021 Mar;23(3):476-485. doi: 10.1002/ejhf.2060. Epub 2020 Dec 7. Eur J Heart Fail. 2021. PMID: 33222412 Free PMC article.
Coronavirus-19: Possible Therapeutic Implications of Spironolactone and Dry Extract of Glycyrrhiza glabra L. (Licorice).
Armanini D, Fiore C, Bielenberg J, Sabbadin C, Bordin L. Armanini D, et al. Front Pharmacol. 2020 Oct 22;11:558418. doi: 10.3389/fphar.2020.558418. eCollection 2020. Front Pharmacol. 2020. PMID: 33192504 Free PMC article.
Protocol for a 30-day randomised, parallel-group, non-inferiority, controlled trial investigating the effects of discontinuing renin-angiotensin system inhibitors in patients with and without COVID-19: the RASCOVID-19 trial.
Kliim-Hansen V, Gasbjerg LS, Ellegaard AM, Lorentsson HJN, Lynggaard MB, Hagemann CA, Legart C, Mathiesen DS, Sivapalan P, Jensen JS, Vilsbøll T, Christensen MB, Knop FK. Kliim-Hansen V, et al. BMJ Open. 2022 Nov 30;12(11):e062895. doi: 10.1136/bmjopen-2022-062895. BMJ Open. 2022. PMID: 36450422 Free PMC article.
The role of vitamin B12 in viral infections: a comprehensive review of its relationship with the muscle-gut-brain axis and implications for SARS-CoV-2 infection.
Batista KS, Cintra VM, Lucena PAF, Manhães-de-Castro R, Toscano AE, Costa LP, Queiroz MEBS, de Andrade SM, Guzman-Quevedo O, Aquino JS. Batista KS, et al. Nutr Rev. 2022 Feb 10;80(3):561-578. doi: 10.1093/nutrit/nuab092. Nutr Rev. 2022. PMID: 34791425 Free PMC article. Review.

See all "Cited by" articles

References

1. https://www.goodreads.com/quotes/4117-there-are-in-fact-two-things-scien.... Accessed 16 April 2020.
1. Fang L, Karakiulakis G and Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respir Med. 2020;8:e21. - PMC - PubMed
1. European Societies of Cardiology. Position Statement of the ESC Council on Hypertension on ACE-Inhibitors and Angiotensin Receptor Blockers. https://www.escardio.org/Councils/Council-on-Hypertension-(CHT)/News/pos.... Accessed 16 April 2020.
1. HFSA/ACC/AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID-19. https://www.acc.org/latest-in-cardiology/articles/2020/03/17/08/59/hfsa-.... Accessed 16 April 2020. - PMC - PubMed
1. Kuster GM, Pfister O, Burkard T, Zhou Q, Twerenbold R, Haaf P, Widmer AF and Osswald S. SARS-CoV2: should inhibitors of the renin-angiotensin system be withdrawn in patients with COVID-19? Eur Heart J. 2020. - PMC - PubMed

Publication types

Actions
Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions

Grants and funding

R01 HL136685/HL/NHLBI NIH HHS/United States

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information
Miscellaneous
- NCI CPTAC Assay Portal

[1] https://www.goodreads.com/quotes/4117-there-are-in-fact-two-things-scien.... Accessed 16 April 2020.

[2] https://www.goodreads.com/quotes/4117-there-are-in-fact-two-things-scien.... Accessed 16 April 2020.

[3] Fang L, Karakiulakis G and Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respir Med. 2020;8:e21. - PMC - PubMed

[4] Fang L, Karakiulakis G and Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respir Med. 2020;8:e21. - PMC - PubMed

[5] European Societies of Cardiology. Position Statement of the ESC Council on Hypertension on ACE-Inhibitors and Angiotensin Receptor Blockers. https://www.escardio.org/Councils/Council-on-Hypertension-(CHT)/News/pos.... Accessed 16 April 2020.

[6] European Societies of Cardiology. Position Statement of the ESC Council on Hypertension on ACE-Inhibitors and Angiotensin Receptor Blockers. https://www.escardio.org/Councils/Council-on-Hypertension-(CHT)/News/pos.... Accessed 16 April 2020.

[7] HFSA/ACC/AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID-19. https://www.acc.org/latest-in-cardiology/articles/2020/03/17/08/59/hfsa-.... Accessed 16 April 2020. - PMC - PubMed

[8] HFSA/ACC/AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID-19. https://www.acc.org/latest-in-cardiology/articles/2020/03/17/08/59/hfsa-.... Accessed 16 April 2020. - PMC - PubMed

[9] Kuster GM, Pfister O, Burkard T, Zhou Q, Twerenbold R, Haaf P, Widmer AF and Osswald S. SARS-CoV2: should inhibitors of the renin-angiotensin system be withdrawn in patients with COVID-19? Eur Heart J. 2020. - PMC - PubMed

[10] Kuster GM, Pfister O, Burkard T, Zhou Q, Twerenbold R, Haaf P, Widmer AF and Osswald S. SARS-CoV2: should inhibitors of the renin-angiotensin system be withdrawn in patients with COVID-19? Eur Heart J. 2020. - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

ACEing COVID-19: A Role for Angiotensin Axis Inhibition in SARS-CoV-2 Infection?

Affiliations

ACEing COVID-19: A Role for Angiotensin Axis Inhibition in SARS-CoV-2 Infection?

Authors

Affiliations

Comment on

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous