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. 1998 Mar;29(1):71-5.

K-ras oncogene and p53 gene mutations in cholangiocarcinoma from Thai patients

S Petmitr  1 , S Pinlaor, A Thousungnoen, A Karalak, P Migasena
Affiliations
  • PMID: 9740272

K-ras oncogene and p53 gene mutations in cholangiocarcinoma from Thai patients

S Petmitr et al. Southeast Asian J Trop Med Public Health. 1998 Mar.

Abstract

Paraffin embedded tissues from twenty Thai patients with intrahepatic cholangiocarcinomas were studied for K-ras gene mutations at codon 12, 13 and 61 and for p53 gene mutations in exon 5 to 8 using polymerase chain reaction and thermal cycle sequencing. Results showed that point mutations at these regions in K-ras oncogene were not present in all the samples. One case harbored a p53 gene mutation in codon 282 in exon 8, CGG (arginine) to TGG (tryptophan), but the mutation was not found in other patient's tissues with similar histological features.

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