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The genetic polymorphisms of intercellular cell adhesion molecules and breast cancer susceptibility: a meta-analysis

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Abstract

Intercellular cell adhesion molecules (ICAMs) genetic polymorphisms have been considered to be implicated in the development of breast cancer. However, the previous reports are conflicting. Therefore, we performed a meta-analysis to assess the association between three polymorphisms, including ICAM1 K469E, ICAM5 V301I, ICAM5 rs281439, and breast cancer risk. The meta-analyses are based on a literature search of PubMed, CNKI and VIP database up until August 2011. Pooled odds ratio (OR) with 95 % confidence interval (CI) was calculated using review manager 5.0.25 package. In total, five populations (2,020 cases and 2,012 controls) on ICAM1 K469E polymorphism, four populations (1,797 cases and 2,244 controls) on ICAM5 V301I polymorphism and five populations (2,744 cases and 3,006 controls) on ICAM5 rs281439 variant were included. Overall, the meta-analysis showed no significant association between ICAM1 K469E polymorphism and breast cancer risk. However, a significant association was observed for ICAM5 V301I polymorphism (VV vs. II: OR = 1.48, 95 % CI 1.04–2.13, P = 0.03; VV/VI vs. II: OR = 1.25, 95 % CI 1.05–1.48, P = 0.01). In addition, there was a significant association between ICAM5 rs281439 variant and breast cancer risk (GG vs. CC: OR = 1.31, 95 % CI 1.03–1.65, P = 0.03). Our meta-analysis suggests that the ICAM5 V301I and rs281439 variants but not ICAM1 K469E polymorphism may contribute to the susceptibility of breast cancer. Given the limited sample sizes, further investigation is needed.

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References

  1. Ellisen LW, Haber DA (1998) Hereditary breast cancer. Annu Rev Med 49:425–436

    Article  PubMed  CAS  Google Scholar 

  2. Rosette C, Roth RB, Oeth P et al (2005) Role of ICAM1 in invasion of human breast cancer cells. Carcinogenesis 26:943–950

    Article  PubMed  CAS  Google Scholar 

  3. Aalinkeel R, Nair MP, Sufrin G et al (2004) Gene expression of angiogenic factors correlates with metastatic potential of prostate cancer cells. Cancer Res 64:5311–5321

    Article  PubMed  CAS  Google Scholar 

  4. Register TC, Burdon KP, Lenchik L et al (2004) Variability of serum soluble intercellular adhesion molecule-1 measurements attributable to a common polymorphism. Clin Chem 50:2185–2187

    Article  PubMed  CAS  Google Scholar 

  5. Kammerer S, Roth RB, Reneland R et al (2004) Large-scale association study identifies ICAM gene region as breast and prostate cancer susceptibility locus. Cancer Res 64:8906–8910

    Article  PubMed  CAS  Google Scholar 

  6. Cox DG, Hankinson SE, Hunter DJ (2006) Polymorphisms in the ICAM gene locus are not associated with breast cancer risk. Cancer Epidemiol Biomarkers Prev 15:178–179

    Article  PubMed  CAS  Google Scholar 

  7. Jiang DH, Zhang WW, li N et al (2006) Effect of interaction between polymorphisms in the ICAM gene locus and BRCA1 on breast cancer risk. Chin J Cancer Prev Treat 13:1609–1613

    CAS  Google Scholar 

  8. Arandi N, Talei A, Erfani N et al (2008) Intercellular adhesion molecule-1 genetic markers (+241G/A and +469A/G) in Iranian women with breast cancer. Cancer Genet Cytogenet 183:9–13

    Article  PubMed  CAS  Google Scholar 

  9. Han W, Kang SY, Kang D et al (2010) Multiplex genotyping of 1107 SNPs from 232 candidate genes identified an association between IL1A polymorphism and breast cancer risk. Oncol Rep 23:763–769

    Article  PubMed  CAS  Google Scholar 

  10. Cox A, Dunning AM, Garcia-Closas M et al (2007) A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet 39:352–358

    Article  PubMed  CAS  Google Scholar 

  11. Hubbard AK, Rothlein R (2000) Intercellular adhesion molecule-1 (ICAM-1) expression and cell signaling cascades. Free Radic Biol Med 28:1379–1386

    Article  PubMed  CAS  Google Scholar 

  12. Braun C, Zahn R, Martin K et al (2001) Polymorphisms of the ICAM-1 gene are associated with inflammatory bowel disease, regardless of the p-ANCA status. Clin Immunol 101:357–360

    Article  PubMed  CAS  Google Scholar 

  13. O’Hanlon DM, Fitzsimons H, Lynch J et al (2002) Soluble adhesion molecules (E-selectin, ICAM-1 and VCAM-1) in breast carcinoma. Eur J Cancer 38:2252–2257

    Article  PubMed  Google Scholar 

  14. Chen H, Hernandez W, Shriver MD et al (2006) ICAM gene cluster SNPs and prostate cancer risk in African Americans. Hum Genet 120:69–76

    Article  PubMed  CAS  Google Scholar 

  15. Theodoropoulos G, Papaconstantinou I, Felekouras E et al (2006) Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer. World J Gastroenterol 12:5037–5043

    PubMed  CAS  Google Scholar 

  16. Wang QL, Li BH, Liu B et al (2009) Polymorphisms of the ICAM-1 exon 6 (E469 K) are associated with differentiation of colorectal cancer. J Exp Clin Cancer Res 28:139

    Article  PubMed  Google Scholar 

  17. Burim RV, Teixeira SA, Colli BO et al (2009) ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) polymorphisms in diffuse astrocytomas. Clin Exp Med 9:157–163

    Article  PubMed  CAS  Google Scholar 

  18. Howell WM, Rose-Zerilli MJ, Theaker JM et al (2005) ICAM-1 polymorphisms and development of cutaneous malignant melanoma. Int J Immunogenet 32:367–373

    Article  PubMed  CAS  Google Scholar 

  19. Vinceti M, Pellacani G, Casali B et al (2006) High risk of cutaneous melanoma amongst carriers of the intercellular adhesion molecule-1 R241 allele. Melanoma Res 16:93–96

    Article  PubMed  CAS  Google Scholar 

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Oncology, Shandong Cancer Hospital and Institute, Jinan, 250117, Shandong, People’s Republic of China

    Lin Liu, Degang Song & Zhehai Wang

  2. Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, 250013, Shandong, People’s Republic of China

    Meili Sun

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  1. Lin Liu
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  2. Meili Sun
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  3. Degang Song
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  4. Zhehai Wang
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Correspondence to Zhehai Wang.

Additional information

Lin Liu and Meili Sun contributed to this article equally.

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Liu, L., Sun, M., Song, D. et al. The genetic polymorphisms of intercellular cell adhesion molecules and breast cancer susceptibility: a meta-analysis. Mol Biol Rep 40, 1855–1860 (2013). https://doi.org/10.1007/s11033-012-2241-4

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  • DOI: https://doi.org/10.1007/s11033-012-2241-4

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