A novel ATPase on mouse chromosome 7 is a candidate gene for increased body fat
- PMID: 11074018
- DOI: 10.1152/physiolgenomics.2000.4.1.93
A novel ATPase on mouse chromosome 7 is a candidate gene for increased body fat
Abstract
A region of mouse chromosome 7, just distal to the pink-eyed (p) dilution locus, contains a gene or genes, which we have named p-locus-associated obesity (plo1), affecting body fat. Mice heterozygous for the most distally extending chromosomal deletions of this region have nearly double the body fat of mice when the deletion is inherited maternally as when it is inherited paternally. We have physically mapped the 1-Mb critical region, which lies between the Gabrb3 and Ube3a/Ipw genes, and DNA sequencing has localized a new member of the third subfamily of P-type ATPases to the minimal region specifying the trait. This gene, which we have called p-locus fat-associated ATPase (pfatp) is differentially expressed in human and mouse tissues with predominant expression in the testis and lower levels of expression in adipose tissue and other organs. We propose this ATPase as the prime candidate for the gene at the plo1 locus modulating body fat content in the mouse. The unusual inheritance pattern of this phenotype suggests either genomic imprinting, known to occur in other local genes (Ube3a, Ipw), or an effect of maternal haploinsufficiency during pregnancy or lactation on body fat in the progeny.
Similar articles
-
Physical mapping of the pink-eyed dilution complex in mouse chromosome 7 shows that Atp10c is the only transcript between Gabrb3 and Ube3a.DNA Seq. 2004 Aug;15(4):306-9. doi: 10.1080/10425170412331279855. DNA Seq. 2004. PMID: 15620220
-
An aminophospholipid translocase associated with body fat and type 2 diabetes phenotypes.Obes Res. 2002 Jul;10(7):695-702. doi: 10.1038/oby.2002.94. Obes Res. 2002. PMID: 12105293
-
A type IV P-type ATPase affects insulin-mediated glucose uptake in adipose tissue and skeletal muscle in mice.J Nutr Biochem. 2006 Dec;17(12):811-20. doi: 10.1016/j.jnutbio.2006.01.002. Epub 2006 Feb 3. J Nutr Biochem. 2006. PMID: 16517145
-
Atp10a, the mouse ortholog of the human imprinted ATP10A gene, escapes genomic imprinting.Genomics. 2003 Jun;81(6):644-7. doi: 10.1016/s0888-7543(03)00077-6. Genomics. 2003. PMID: 12782135
-
The role of the FTO (Fat Mass and Obesity Related) locus in regulating body size and composition.Mol Cell Endocrinol. 2014 Nov;397(1-2):34-41. doi: 10.1016/j.mce.2014.09.012. Epub 2014 Sep 16. Mol Cell Endocrinol. 2014. PMID: 25224490 Review.
Cited by
-
Maternal disruption of Ube3a leads to increased expression of Ube3a-ATS in trans.Nucleic Acids Res. 2005 Jul 18;33(13):3976-84. doi: 10.1093/nar/gki705. Print 2005. Nucleic Acids Res. 2005. PMID: 16027444 Free PMC article.
-
Predominant maternal expression of the mouse Atp10c in hippocampus and olfactory bulb.J Hum Genet. 2003;48(4):194-8. doi: 10.1007/s10038-003-0009-3. Epub 2003 Mar 12. J Hum Genet. 2003. PMID: 12730723
-
Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons.Am J Hum Genet. 2003 Oct;73(4):898-925. doi: 10.1086/378816. Epub 2003 Sep 23. Am J Hum Genet. 2003. PMID: 14508708 Free PMC article.
-
Phospholipid flippases: building asymmetric membranes and transport vesicles.Biochim Biophys Acta. 2012 Aug;1821(8):1068-77. doi: 10.1016/j.bbalip.2011.12.007. Epub 2011 Dec 31. Biochim Biophys Acta. 2012. PMID: 22234261 Free PMC article. Review.
-
Atp10a, a gene adjacent to the PWS/AS gene cluster, is not imprinted in mouse and is insensitive to the PWS-IC.Neurogenetics. 2010 May;11(2):145-51. doi: 10.1007/s10048-009-0226-9. Epub 2009 Nov 6. Neurogenetics. 2010. PMID: 19894069
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous
