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. 2001 Sep 14;293(5537):2108-11.
doi: 10.1126/science.1061965. Epub 2001 Aug 16.

BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF

J S Thompson  1 , S A Bixler, F Qian, K Vora, M L Scott, T G Cachero, C Hession, P Schneider, I D Sizing, C Mullen, K Strauch, M Zafari, C D Benjamin, J Tschopp, J L Browning, C Ambrose
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BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF

J S Thompson et al. Science. .

Abstract

B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAFF that we have termed BAFF-R. BAFF-R binding appears to be highly specific for BAFF, suggesting a unique role for this ligand-receptor interaction. Consistent with this, the BAFF-R locus is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAFF-deficient mice. Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival.

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