Review
doi: 10.1016/s0166-2236(02)02169-0.
Jekyll-Hyde neurotrophins: the story of proNGF
Affiliations
- PMID: 12086739
- DOI: 10.1016/s0166-2236(02)02169-0
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Review
Jekyll-Hyde neurotrophins: the story of proNGF
Trends Neurosci.
2002 Jun.
Erratum in
- Trends Neurosci 2002 Jul;25(7):378
Abstract
Neurotrophins promote neuronal survival and differentiation by binding to two classes of cell surface receptors: members of the Trk-family receptor tyrosine kinases and p75(NTR), a member of the tumor necrosis factor receptor superfamily. The discoveries that the unprocessed proneurotrophin peptide is both a preferential high-affinity ligand for p75(NTR) (with minimal affinity for trkA) and a potent inducer of p75(NTR)-mediated neuronal cell death are likely to change our understanding of neurotrophin physiology and our ability to manipulate their signaling pathways.
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