Viruses and interferon: a fight for supremacy
- PMID: 12209136
- DOI: 10.1038/nri888
Viruses and interferon: a fight for supremacy
Abstract
The action of interferons (IFNs) on virus-infected cells and surrounding tissues elicits an antiviral state that is characterized by the expression and antiviral activity of IFN-stimulated genes. In turn, viruses encode mechanisms to counteract the host response and support efficient viral replication, thereby minimizing the therapeutic antiviral power of IFNs. In this review, we discuss the interplay between the IFN system and four medically important and challenging viruses -- influenza, hepatitis C, herpes simplex and vaccinia -- to highlight the diversity of viral strategies. Understanding the complex network of cellular antiviral processes and virus-host interactions should aid in identifying new and common targets for the therapeutic intervention of virus infection. This effort must take advantage of the recent developments in functional genomics, bioinformatics and other emerging technologies.
Similar articles
-
The Toll of herpes simplex virus infection.Trends Microbiol. 2004 Aug;12(8):353-6. doi: 10.1016/j.tim.2004.06.001. Trends Microbiol. 2004. PMID: 15276609 Review.
-
The interferon response to bacterial and viral infections.J Endotoxin Res. 2006;12(4):246-50. doi: 10.1179/096805106X118799. J Endotoxin Res. 2006. PMID: 16953977
-
Infectious salmon anemia virus is a powerful inducer of key genes of the type I interferon system of Atlantic salmon, but is not inhibited by interferon.Fish Shellfish Immunol. 2007 Aug;23(2):378-89. doi: 10.1016/j.fsi.2006.11.011. Epub 2006 Dec 3. Fish Shellfish Immunol. 2007. PMID: 17257858
-
[The first answer to viral infections: type I interferon].Berl Munch Tierarztl Wochenschr. 2004 Jul-Aug;117(7-8):252-65. Berl Munch Tierarztl Wochenschr. 2004. PMID: 15298051 Review. German.
-
Activation of mast cells by double-stranded RNA: evidence for activation through Toll-like receptor 3.J Allergy Clin Immunol. 2004 Jul;114(1):174-82. doi: 10.1016/j.jaci.2004.03.049. J Allergy Clin Immunol. 2004. PMID: 15241362
Cited by
-
High-throughput profiling of alpha interferon- and interleukin-28B-regulated microRNAs and identification of let-7s with anti-hepatitis C virus activity by targeting IGF2BP1.J Virol. 2013 Sep;87(17):9707-18. doi: 10.1128/JVI.00802-13. Epub 2013 Jul 3. J Virol. 2013. PMID: 23824794 Free PMC article.
-
IBD Patients Could Be Silent Carriers for Novel Coronavirus and Less Prone to its Severe Adverse Events: True or False?Cell J. 2020 Jul;22(Suppl 1):151-154. doi: 10.22074/cellj.2020.7603. Epub 2020 Jul 18. Cell J. 2020. PMID: 32779446 Free PMC article.
-
Mechanisms of Borrelia burgdorferi internalization and intracellular innate immune signaling.Front Cell Infect Microbiol. 2014 Dec 15;4:175. doi: 10.3389/fcimb.2014.00175. eCollection 2014. Front Cell Infect Microbiol. 2014. PMID: 25566512 Free PMC article. Review.
-
Innate lymphoid cells are activated in HFRS, and their function can be modulated by hantavirus-induced type I interferons.PLoS Pathog. 2024 Jul 22;20(7):e1012390. doi: 10.1371/journal.ppat.1012390. eCollection 2024 Jul. PLoS Pathog. 2024. PMID: 39038044 Free PMC article.
-
Systemic Administration of Cowpea Mosaic Virus Demonstrates Broad Protection Against Metastatic Cancers.Adv Sci (Weinh). 2024 May;11(18):e2308237. doi: 10.1002/advs.202308237. Epub 2024 Mar 2. Adv Sci (Weinh). 2024. PMID: 38430536 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
