Translational control by the 3'-UTR: the ends specify the means
- PMID: 12575997
- DOI: 10.1016/S0968-0004(03)00002-1
Translational control by the 3'-UTR: the ends specify the means
Abstract
In most cases, translational control mechanisms result from the interaction of RNA-binding proteins with 5'- or 3'-untranslated regions (UTRs) of mRNA. In organisms ranging from viruses to humans, protein-mediated interactions between transcript termini result in the formation of an RNA loop. Such RNA 'circularization' is thought to increase translational efficiency and, in addition, permits regulation by novel mechanisms, particularly 3'-UTR-mediated translational control. Two general mechanisms of translational inhibition by 3'-UTR-binding proteins have been proposed, one in which mRNA closure is disrupted and another in which mRNA closure is required. Experimental evidence for the latter is provided by studies of interferon-gamma-mediated translational silencing of ceruloplasmin expression in monocytic cells. A multi-species analysis has shown that, in most vertebrates, 3'-UTRs are substantially longer than their 5' counterparts, indicating a significant potential for regulation. In addition, the average length of 3'-UTR sequences has increased during evolution, suggesting that their utilization might contribute to organism complexity.
Similar articles
-
Translational silencing of ceruloplasmin requires the essential elements of mRNA circularization: poly(A) tail, poly(A)-binding protein, and eukaryotic translation initiation factor 4G.Mol Cell Biol. 2001 Oct;21(19):6440-9. doi: 10.1128/MCB.21.19.6440-6449.2001. Mol Cell Biol. 2001. PMID: 11533233 Free PMC article.
-
Delayed translational silencing of ceruloplasmin transcript in gamma interferon-activated U937 monocytic cells: role of the 3' untranslated region.Mol Cell Biol. 1999 Oct;19(10):6898-905. doi: 10.1128/MCB.19.10.6898. Mol Cell Biol. 1999. PMID: 10490627 Free PMC article.
-
Transcript-selective translational silencing by gamma interferon is directed by a novel structural element in the ceruloplasmin mRNA 3' untranslated region.Mol Cell Biol. 2003 Mar;23(5):1509-19. doi: 10.1128/MCB.23.5.1509-1519.2003. Mol Cell Biol. 2003. PMID: 12588972 Free PMC article.
-
Regulation of macrophage ceruloplasmin gene expression: one paradigm of 3'-UTR-mediated translational control.Mol Cells. 2005 Oct 31;20(2):167-72. Mol Cells. 2005. PMID: 16267389 Review.
-
Post-transcriptional and post-translational regulation of Bcl2.Biochem Soc Trans. 2010 Dec;38(6):1571-5. doi: 10.1042/BST0381571. Biochem Soc Trans. 2010. PMID: 21118128 Review.
Cited by
-
Catalytic efficiency diversification of duplicate β-1,3-1,4-glucanases from Neocallimastix patriciarum J11.Appl Environ Microbiol. 2012 Jun;78(12):4294-300. doi: 10.1128/AEM.07473-11. Epub 2012 Apr 6. Appl Environ Microbiol. 2012. PMID: 22492445 Free PMC article.
-
Respiratory Syncytial Virus (RSV) optimizes the translational landscape during infection.bioRxiv [Preprint]. 2024 Aug 3:2024.08.02.606199. doi: 10.1101/2024.08.02.606199. bioRxiv. 2024. PMID: 39131278 Free PMC article. Preprint.
-
Hyper conserved elements in vertebrate mRNA 3'-UTRs reveal a translational network of RNA-binding proteins controlled by HuR.Nucleic Acids Res. 2013 Mar 1;41(5):3201-16. doi: 10.1093/nar/gkt017. Epub 2013 Feb 1. Nucleic Acids Res. 2013. PMID: 23376935 Free PMC article.
-
Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling.J Clin Invest. 2006 Oct;116(10):2727-38. doi: 10.1172/JCI27209. Epub 2006 Sep 21. J Clin Invest. 2006. PMID: 16998585 Free PMC article.
-
Comparative analysis of orthologous eukaryotic mRNAs: potential hidden functional signals.Nucleic Acids Res. 2004 Mar 18;32(5):1774-82. doi: 10.1093/nar/gkh313. Print 2004. Nucleic Acids Res. 2004. PMID: 15031317 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
