Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003;4(5):P3.
Epub 2003 Apr 3.

DAVID: Database for Annotation, Visualization, and Integrated Discovery

Glynn Dennis Jr  1 , Brad T Sherman, Douglas A Hosack, Jun Yang, Wei Gao, H Clifford Lane, Richard A Lempicki
Affiliations
  • PMID: 12734009

DAVID: Database for Annotation, Visualization, and Integrated Discovery

Glynn Dennis Jr et al. Genome Biol. 2003.

Abstract

Background: Functional annotation of differentially expressed genes is a necessary and critical step in the analysis of microarray data. The distributed nature of biological knowledge frequently requires researchers to navigate through numerous web-accessible databases gathering information one gene at a time. A more judicious approach is to provide query-based access to an integrated database that disseminates biologically rich information across large datasets and displays graphic summaries of functional information.

Results: Database for Annotation, Visualization, and Integrated Discovery (DAVID; http://www.david.niaid.nih.gov) addresses this need via four web-based analysis modules: 1) Annotation Tool - rapidly appends descriptive data from several public databases to lists of genes; 2) GoCharts - assigns genes to Gene Ontology functional categories based on user selected classifications and term specificity level; 3) KeggCharts - assigns genes to KEGG metabolic processes and enables users to view genes in the context of biochemical pathway maps; and 4) DomainCharts - groups genes according to PFAM conserved protein domains.

Conclusions: Analysis results and graphical displays remain dynamically linked to primary data and external data repositories, thereby furnishing in-depth as well as broad-based data coverage. The functionality provided by DAVID accelerates the analysis of genome-scale datasets by facilitating the transition from data collection to biological meaning.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nucleic Acids Res. 2000 Jan 1;28(1):10-4 - PubMed
    1. Nucleic Acids Res. 2000 Jan 1;28(1):27-30 - PubMed
    1. Nat Genet. 2000 May;25(1):25-9 - PubMed
    1. Nucleic Acids Res. 2001 Jan 1;29(1):75-9 - PubMed
    1. Nat Rev Genet. 2001 Jun;2(6):418-27 - PubMed

Publication types

MeSH terms

LinkOut - more resources