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. 2003 Sep;4(3):209-21.
doi: 10.1016/s1535-6108(03)00215-0.

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

Shunyou Wang  1 , Jing Gao, Qunying Lei, Nora Rozengurt, Colin Pritchard, Jing Jiao, George V Thomas, Gang Li, Pradip Roy-Burman, Peter S Nelson, Xin Liu, Hong Wu
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Free article

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

Shunyou Wang et al. Cancer Cell. 2003 Sep.
Free article

Abstract

The murine Pten prostate cancer model described in this study recapitulates the disease progression seen in humans: initiation of prostate cancer with prostatic intraepithelial neoplasia (PIN), followed by progression to invasive adenocarcinoma, and subsequent metastasis with defined kinetics. Furthermore, while Pten null prostate cancers regress after androgen ablation, they are capable of proliferating in the absence of androgen. Global assessment of molecular changes caused by homozygous Pten deletion identified key genes known to be relevant to human prostate cancer, including those "signature" genes associated with human cancer metastasis. This murine prostate cancer model provides a unique tool for both exploring the molecular mechanism underlying prostate cancer and for development of new targeted therapies.

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