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Review
. 2006 Oct;18(5):318-26.
doi: 10.1016/j.smim.2006.06.001. Epub 2006 Aug 22.

BLyS and B cell homeostasis

Robert T Woodland  1 , Madelyn R Schmidt, Craig B Thompson
Affiliations
Review

BLyS and B cell homeostasis

Robert T Woodland et al. Semin Immunol. 2006 Oct.

Abstract

Naïve peripheral B cells survive in vivo because of active stimulation by the TNF superfamily ligand B lymphocyte stimulator (BLyS/BAFF). Although the survival promoting properties of BLyS are well known, the signal pathways and molecular effectors that characterize this stimulation are still being elucidated. In this communication, we discuss the signal cascades that effect BLyS dependent survival and the regulation of BLyS induced signaling. We also examine the role of BLyS as a growth factor and propose that BLyS induced metabolic enhancement optimizes the B cell response to BCR and TLR-dependent signaling.

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