Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Mar;132(3):455-62.
doi: 10.1002/ajpa.20534.

Argentine population genetic structure: large variance in Amerindian contribution

Michael F Seldin  1 , Chao Tian, Russell Shigeta, Hugo R Scherbarth, Gabriel Silva, John W Belmont, Rick Kittles, Susana Gamron, Alberto Allevi, Simon A Palatnik, Alejandro Alvarellos, Sergio Paira, Cesar Caprarulo, Carolina Guillerón, Luis J Catoggio, Cristina Prigione, Guillermo A Berbotto, Mercedes A García, Carlos E Perandones, Bernardo A Pons-Estel, Marta E Alarcon-Riquelme
Affiliations

Argentine population genetic structure: large variance in Amerindian contribution

Michael F Seldin et al. Am J Phys Anthropol. 2007 Mar.

Abstract

Argentine population genetic structure was examined using a set of 78 ancestry informative markers (AIMs) to assess the contributions of European, Amerindian, and African ancestry in 94 individuals members of this population. Using the Bayesian clustering algorithm STRUCTURE, the mean European contribution was 78%, the Amerindian contribution was 19.4%, and the African contribution was 2.5%. Similar results were found using weighted least mean square method: European, 80.2%; Amerindian, 18.1%; and African, 1.7%. Consistent with previous studies the current results showed very few individuals (four of 94) with greater than 10% African admixture. Notably, when individual admixture was examined, the Amerindian and European admixture showed a very large variance and individual Amerindian contribution ranged from 1.5 to 84.5% in the 94 individual Argentine subjects. These results indicate that admixture must be considered when clinical epidemiology or case control genetic analyses are studied in this population. Moreover, the current study provides a set of informative SNPs that can be used to ascertain or control for this potentially hidden stratification. In addition, the large variance in admixture proportions in individual Argentine subjects shown by this study suggests that this population is appropriate for future admixture mapping studies.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Estimation of ancestry contributions to the Argentine population using by a Bayesian analysis of population genetic structure. In panel A the results of STRUCTURE analysis (k = 3) using 44 AIMs selected for European, Amerindian, and African information (see methods) are shown. In panel B the results of STRUCTURE analysis using 66 European/Amerindian AIMs (k = 2) is shown. For both panel A and B, the mean population group assignment is shown by color code and the number of subjects in each group is shown in parenthesis. The population groups were European American (EURA), Amerindian (AMI), West African, (AFR), Mexican (MXN), Mexican American (MAM), and Argentine (ARG). In Panel B, the standard deviation is shown for the Amerindian assignment of the individuals. The large standard deviation (SD) observed in the admixed populations are due to the large variation in the individual members of these population groups. The variation in the means between different STRUCTURE runs is <0.5%. In Panel C the same results as panel A are shown for 88 individual EURA subjects (blue), 70 AMI subjects (red), 95 AFR subjects (green), and 94 ARG subjects (magenta) in a triangle plot of the color coded cluster groups corresponding to self identified population affiliations.
Fig. 2
Fig. 2
Probability estimations for the number cluster groups (“ancestral or founder populations”) present using AIMs. The ordinate shows the Ln probability (±SD from 5 separate runs) corresponding to the number of clusters (K) when Argentine samples alone are examined with the 44 AIMs selected for distinguishing between European, Amerindian, and African population groups.
Fig. 3
Fig. 3
A, Analysis of population genetic structure in individuals of European, Amerindian, Argentine, and Mexican American origin. Each symbol represents an individual examined with 66 selected AIMs and analyzed using the STRUCTURE program under the condition of two populations. The position of the symbol on the Y-axis indicates the most probable admixture from Amerindian (proximity to 0) or the European population (proximity to 1.0) and the error bars show 90% Bayesian confidence limits, e.g., the Argentine subject with the largest Amerindian contribution. In panel B, the Argentine results are shown separated by regional recruitment areas and included Buenos Aires (15 subjects), Córdoba (33 subjects), Santa Fé (33 subjects), and Mar del Plata (11 subjects). Two individuals recruited from La Plata were not included (subject 1, 0.967 European; subject 2, 0.948 European).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Avena SA, Goicoechea AS, Dugoujon JM, Slepoy MG, Slepoy ES, Carnese FR. Analisis antropogenetico de los aportes indigena y Africano en Muestras Hospitalaras de la ciudad de Buenos Aires. Rev Argent Antropol Biol. 2001;3:79–99.
    1. Belkhir K, Borsa P, Chikhi L, Raufaste N, Bonhomme F. GENETIX, software under Windows™ for the genetic of populations. Laboratory Genome, Populations, Interactions CNRS UMR 5000, University of Montpellier II; Montpellier, France: 2001.
    1. Bonilla C, Shriver MD, Parra EJ, Jones A, Fernandez JR. Ancestral proportions and their association with skin pigmentation and bone mineral density in Puerto Rican women from New York city. Hum Genet. 2004;115:57–68. - PubMed
    1. Burchard EG, Ziv E, Coyle N, Gomez SL, Tang H, Karter AJ, Mountain JL, Perez-Stable EJ, Sheppard D, Risch N. The importance of race and ethnic background in biomedical research and clinical practice. N Engl J Med. 2003;348:1170–1175. - PubMed
    1. Collado-Mesa F, Barcelo A, Arheart KL, Messiah SE. An ecological analysis of childhood-onset type 1 diabetes incidence and prevalence in Latin America. Rev Panam Salud Publica. 2004;15:388–394. - PubMed

Publication types

Substances

LinkOut - more resources