Review
doi: 10.1021/bi800049z.
Epub 2008 Feb 26.
Free-energy landscape of enzyme catalysis
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- PMID: 18298083
- DOI: 10.1021/bi800049z
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Review
Free-energy landscape of enzyme catalysis
Biochemistry.
.
Abstract
The concept is developed that enzyme mechanisms should be viewed as "catalytic networks" with multiple conformations that occur serially and in parallel in the mechanism. These coupled ensembles of conformations require a multi-dimensional standard free-energy surface that is very "rugged", containing multiple minima and transition states. Experimental and theoretical evidence is presented to support this concept.
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