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Review
. 2008 Jul;4(7):726-32.
doi: 10.1039/b706237k. Epub 2008 Apr 17.

The incredible shrinking world of DNA microarrays

Sarah J Wheelan  1 , Francisco Martínez Murillo, Jef D Boeke
Affiliations
Review

The incredible shrinking world of DNA microarrays

Sarah J Wheelan et al. Mol Biosyst. 2008 Jul.

Abstract

The efficacy of microarrays in examining gene expression, gene and genome structure, protein-DNA interactions, whole-genome similarities and differences, microRNA expression, methylation (and more) is no longer in question. It is a fast-developing, cutting edge technology that has grown up along with massive sequence databases and is likely to become part of everyday patient care. Many advances have recently expanded the power and utility of microarrays; among them is our development of a new array tiling technique that dramatically increases the scope of coverage of an oligonucleotide tiling array without substantially increasing its cost.

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Figures

Figure 1
Figure 1
Dramatic increase in microarray citations with time (PubMed). From just over 100 publications at the end of 1999, the number of microarray citations has been exponentially increasing with each passing year, reaching over 5,200 papers in 2006, numbering more than 22,500 publications in all. In the first 11 months of 2007, there have been over 5,516 microarray publications, on track for a potential total of >6,000 additional microarray publications for the year. In red is the per-year number of publications, in purple the cumulative tally.
Figure 2
Figure 2. Construction of a probe for a double-tiled array
The conventional probe is one contiguous piece of sequence, while the double-tiled probe consists of two discontinuous sequences fused together.
See this image and copyright information in PMC

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