Review
doi: 10.1146/annurev-genom-082908-145957.
Applications of new sequencing technologies for transcriptome analysis
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- PMID: 19715439
- DOI: 10.1146/annurev-genom-082908-145957
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Review
Applications of new sequencing technologies for transcriptome analysis
Annu Rev Genomics Hum Genet.
2009.
Abstract
Transcriptome analysis has been a key area of biological inquiry for decades. Over the years, research in the field has progressed from candidate gene-based detection of RNAs using Northern blotting to high-throughput expression profiling driven by the advent of microarrays. Next-generation sequencing technologies have revolutionized transcriptomics by providing opportunities for multidimensional examinations of cellular transcriptomes in which high-throughput expression data are obtained at a single-base resolution.
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