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Review
. 2010 Feb;10(2):116-29.
doi: 10.1038/nrc2780.

Fibroblast growth factor signalling: from development to cancer

Nicholas Turner  1 , Richard Grose
Affiliations
Review

Fibroblast growth factor signalling: from development to cancer

Nicholas Turner et al. Nat Rev Cancer. 2010 Feb.

Abstract

Fibroblast growth factors (FGFs) and their receptors control a wide range of biological functions, regulating cellular proliferation, survival, migration and differentiation. Although targeting FGF signalling as a cancer therapeutic target has lagged behind that of other receptor tyrosine kinases, there is now substantial evidence for the importance of FGF signalling in the pathogenesis of diverse tumour types, and clinical reagents that specifically target the FGFs or FGF receptors are being developed. Although FGF signalling can drive tumorigenesis, in different contexts FGF signalling can mediate tumour protective functions; the identification of the mechanisms that underlie these differential effects will be important to understand how FGF signalling can be most appropriately therapeutically targeted.

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References

    1. J Clin Oncol. 2001 Feb 15;19(4):1207-25 - PubMed
    1. J Biol Chem. 2001 Aug 24;276(34):32382-91 - PubMed
    1. Cancer Res. 2008 Apr 1;68(7):2340-8 - PubMed
    1. Genomics. 2000 Oct 15;69(2):275-9 - PubMed
    1. J Biol Chem. 2006 Jun 9;281(23):15694-700 - PubMed

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