Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Feb;21(1):1-4.
doi: 10.1097/YPG.0b013e3283413382.

Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes

David Curtis  1 , Anna E Vine, Andrew McQuillin, Nicholas James Bass, Ana Pereira, Radhika Kandaswamy, Jacob Lawrence, Adebayo Anjorin, Khalid Choudhury, Susmita R Datta, Vinay Puri, Robert Krasucki, Jonathan Pimm, Srinivasa Thirumalai, Digby Quested, Hugh M D Gurling
Affiliations

Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes

David Curtis et al. Psychiatr Genet. 2011 Feb.

Abstract

Objective: There are theoretical reasons why comparing marker allele frequencies between cases of different diseases, rather than with controls, may offer benefits. The samples may be better matched, especially for background risk factors common to both diseases. Genetic loci may also be detected which influence which of the two diseases occurs if common risk factors are present.

Method: We used samples of UK bipolar and schizophrenic cases that had earlier been subject to genome-wide association studies and compared marker allele frequencies between the two samples. When these differed for a marker, we compared the case sample allele frequencies with those of a control sample.

Results: Eight markers were significant at P value of less than 10(-5). Of these, the most interesting finding was for rs17645023, which was significant at P value of less than 10(-6) and which lies 36 kb from CACNG5. Control allele frequencies for this marker were intermediate between those for bipolar and schizophrenic cases.

Conclusion: The application of this approach suggests that it does have some merits. The finding for CACNG5, taken together with the earlier implication of CACNA1C and CACNA1B, strongly suggests a key role for voltage-dependent calcium channel genes in the susceptibility to bipolar disorder and/or schizophrenia.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Bass NJ, Datta SR, McQuillin A, Puri V, Choudhury K, Thirumalai S, et al. Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia. Behav Brain Funct. 2009;5:28. - PMC - PubMed
    1. Curtis D, Vine AE, Knight J. A pragmatic suggestion for dealing with results for candidate genes obtained from genome wide association studies. BMC Genet. 2007;8:20. - PMC - PubMed
    1. Datta SR, McQuillin A, Rizig M, Blaveri E, Thirumalai S, Kalsi G, et al. A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophrenia. Mol Psychiatry. 2008 - PubMed
    1. Ferreira MA, O’Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, et al. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet. 2008;40(9):1056–8. - PMC - PubMed
    1. Hennah W, Thomson P, McQuillin A, Bass N, Loukola A, Anjorin A, et al. DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder. Mol Psychiatry. 2009;14(9):865–73. - PubMed

Publication types