One hundred years of chromium and cancer: a review of epidemiological evidence and selected case reports
- PMID: 2405656
- DOI: 10.1002/ajim.4700170205
One hundred years of chromium and cancer: a review of epidemiological evidence and selected case reports
Abstract
The present review is motivated by the fact that 100 years have passed since the first cancer case in a chromium worker was reported in Scotland. Old and recent case reports and epidemiological studies among chromate workers are reviewed to elucidate the importance of valency states and water solubility of chromium compounds for carcinogenic potency. It is concluded that all chromium[VI] compounds should be considered carcinogenic among exposed populations, and that no evidence has been presented indicating that human exposure to chromium[III] is associated with increased cancer risk. Strong evidence has been presented that zinc chromate is a potent carcinogen and suggests that calcium chromate may be a potent carcinogen. Evidence also suggests that water-soluble chromates in general may be more potent carcinogens than those with low solubility. Primary and secondary prevention of chromate-related cancer and the success in preventive measures are briefly discussed, and recommendations for future research are made.
Similar articles
-
Role of chemical species and exposure characteristics in cancer among persons occupationally exposed to chromium compounds.Scand J Work Environ Health. 1993;19 Suppl 1:81-9. Scand J Work Environ Health. 1993. PMID: 8159981 Review.
-
Chromium carcinogenicity; a review of experimental animal data.Sci Total Environ. 1988 Jun 1;71(3):341-50. doi: 10.1016/0048-9697(88)90206-9. Sci Total Environ. 1988. PMID: 3043656 Review.
-
Cytotoxic and neoplastic transforming effects of industrial hexavalent chromium pigments in Syrian hamster embryo cells.Carcinogenesis. 1989 Nov;10(11):2043-52. doi: 10.1093/carcin/10.11.2043. Carcinogenesis. 1989. PMID: 2680145
-
Lead chromate-induced chromosome damage requires extracellular dissolution to liberate chromium ions but does not require particle internalization or intracellular dissolution.Chem Res Toxicol. 2004 Oct;17(10):1362-7. doi: 10.1021/tx0498509. Chem Res Toxicol. 2004. PMID: 15487897
-
Lung cancer mortality among a cohort of male chromate pigment workers in Japan.Int J Epidemiol. 1993 Feb;22(1):16-22. doi: 10.1093/ije/22.1.16. Int J Epidemiol. 1993. PMID: 8449638
Cited by
-
Environmentally induced ribosomal DNA (rDNA) instability in human cells and populations exposed to hexavalent chromium [Cr (VI)].Environ Int. 2021 Aug;153:106525. doi: 10.1016/j.envint.2021.106525. Epub 2021 Mar 25. Environ Int. 2021. PMID: 33774497 Free PMC article.
-
NF-kappaB prevents cells from undergoing Cr(VI)-induced apoptosis.Mol Cell Biochem. 2004 Jan;255(1-2):129-37. doi: 10.1023/b:mcbi.0000007269.74532.98. Mol Cell Biochem. 2004. PMID: 14971654
-
Utilization of DNA-protein cross-links as a biomarker of chromium exposure.Environ Health Perspect. 1998 Aug;106 Suppl 4(Suppl 4):969-74. doi: 10.1289/ehp.98106s4969. Environ Health Perspect. 1998. PMID: 9703480 Free PMC article.
-
The cyanobacterium Synechocystis sp. PUPCCC 62: a potential candidate for biotransformation of Cr(VI) to Cr(III) in the presence of sulphate.Environ Sci Pollut Res Int. 2015 Jul;22(14):10661-8. doi: 10.1007/s11356-015-4260-x. Epub 2015 Mar 11. Environ Sci Pollut Res Int. 2015. PMID: 25752632
-
Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase inhibitor: enhanced survival and mutagenesis.Mutat Res. 2009 Jan 15;660(1-2):40-6. doi: 10.1016/j.mrfmmm.2008.10.006. Epub 2008 Oct 21. Mutat Res. 2009. PMID: 19013184 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical