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Review
. 2014 May;15(5):444-54.
doi: 10.1631/jzus.B1400088.

mRNA stability in the nucleus

Han Liu  1 , Min Luo, Ji-kai Wen
Affiliations
Review

mRNA stability in the nucleus

Han Liu et al. J Zhejiang Univ Sci B. 2014 May.

Abstract

Eukaryotic gene expression is controlled by different levels of biological events, such as transcription factors regulating the timing and strength of transcripts production, alteration of transcription rate by RNA processing, and mRNA stability during RNA processing and translation. RNAs, especially mRNAs, are relatively vulnerable molecules in living cells for ribonucleases (RNases). The maintenance of quality and quantity of transcripts is a key issue for many biological processes. Extensive studies draw the conclusion that the stability of RNAs is dedicated-regulated, occurring co- and post-transcriptionally, and translation-coupled as well, either in the nucleus or cytoplasm. Recently, RNA stability in the nucleus has aroused much research interest, especially the stability of newly-made transcripts. In this article, we summarize recent progresses on mRNA stability in the nucleus, especially focusing on quality control of newly-made RNA by RNA polymerase II in eukaryotes.

Keywords: Nuclear mRNA retention; Quality control; mRNA degradation; mRNA stability.

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Conflict of interest statement

Compliance with ethics guidelines: Han LIU, Min LUO, and Ji-kai WEN declare that they have no conflict of interest.

This article does not contain any studies with human or animal subjects performed by any of the authors.

Figures

Fig. 1
Fig. 1
Quality control pathways ubiquitously occurring at many steps of transcription and mRNA processing
Fig. 2
Fig. 2
Degradation of CUTs in the nucleus
See this image and copyright information in PMC

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