Light-induced retinal damage using different light sources, protocols and rat strains reveals LED phototoxicity
- PMID: 27751961
- DOI: 10.1016/j.neuroscience.2016.10.015
Light-induced retinal damage using different light sources, protocols and rat strains reveals LED phototoxicity
Abstract
To save energy, the European directives from the Eco-design of Energy Using Products (2005/32/CE) have recommended the replacement of incandescent lamps by more economic devices such as Light Emitting Diodes (LEDs). However, the emission spectrum of these devices is enriched in blue radiations, known to be potentially dangerous to the retina. Recent studies showed that light exposure contributes to the onset of early stages of age-related macular degeneration (AMD). Here, we investigate, in albinos and pigmented rats, the effects of different exposure protocols. Twenty-four hours exposure at high luminance was compared to a cyclic (dark/light) exposure at domestic levels for 1week and 1month, using different LEDs (Cold-white, blue and green), as well as fluorocompact bulbs and fluorescent tubes. The data suggest that the blue component of the white-LED may cause retinal toxicity at occupational domestic illuminance and not only in extreme experimental conditions, as previously reported. It is important to note that the current regulations and standards have been established on the basis of acute light exposure and do not take into account the effects of repeated exposure.
Keywords: Light Emitting Diodes; chronic light exposure; phototoxicity; pigmented rats; retina.
Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.
Similar articles
-
Retinal damage induced by commercial light emitting diodes (LEDs).Free Radic Biol Med. 2015 Jul;84:373-384. doi: 10.1016/j.freeradbiomed.2015.03.034. Epub 2015 Apr 8. Free Radic Biol Med. 2015. PMID: 25863264
-
White light-emitting diodes (LEDs) at domestic lighting levels and retinal injury in a rat model.Environ Health Perspect. 2014 Mar;122(3):269-76. doi: 10.1289/ehp.1307294. Epub 2013 Dec 20. Environ Health Perspect. 2014. PMID: 24362357 Free PMC article.
-
Rhodopsin-mediated blue-light damage to the rat retina: effect of photoreversal of bleaching.Invest Ophthalmol Vis Sci. 2001 Feb;42(2):497-505. Invest Ophthalmol Vis Sci. 2001. PMID: 11157889
-
[The dangers of blue light: True story!].J Fr Ophtalmol. 2016 May;39(5):483-8. doi: 10.1016/j.jfo.2016.02.003. Epub 2016 Mar 31. J Fr Ophtalmol. 2016. PMID: 27039979 Review. French.
-
Light-emitting diodes (LED) for domestic lighting: any risks for the eye?Prog Retin Eye Res. 2011 Jul;30(4):239-57. doi: 10.1016/j.preteyeres.2011.04.002. Epub 2011 May 14. Prog Retin Eye Res. 2011. PMID: 21600300 Review.
Cited by
-
Higher Risk of Light-Induced Retinal Damage Due to Increase of Intraocular Irradiance by Endoillumination.Ophthalmol Ther. 2019 Mar;8(1):41-50. doi: 10.1007/s40123-018-0157-3. Epub 2018 Dec 17. Ophthalmol Ther. 2019. PMID: 30560504 Free PMC article.
-
Analysis of Electric Field Stimulation in Blue Light Stressed 661W Cells.Int J Mol Sci. 2023 Feb 8;24(4):3433. doi: 10.3390/ijms24043433. Int J Mol Sci. 2023. PMID: 36834840 Free PMC article.
-
Animal Models of LED-Induced Phototoxicity. Short- and Long-Term In Vivo and Ex Vivo Retinal Alterations.Life (Basel). 2021 Oct 26;11(11):1137. doi: 10.3390/life11111137. Life (Basel). 2021. PMID: 34833013 Free PMC article. Review.
-
Neuroprotective Effect of siRNA Entrapped in Hyaluronic Acid-Coated Lipoplexes by Intravitreal Administration.Pharmaceutics. 2021 Jun 8;13(6):845. doi: 10.3390/pharmaceutics13060845. Pharmaceutics. 2021. PMID: 34200993 Free PMC article.
-
Structural and Functional Change in Albino Rat Retina Induced by Various Visible Light Wavelengths.Int J Mol Sci. 2021 Dec 28;23(1):309. doi: 10.3390/ijms23010309. Int J Mol Sci. 2021. PMID: 35008736 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
