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. 1989 Sep 15;163(2):1071-8.
doi: 10.1016/0006-291x(89)92330-9.

Connective tissue activation. XXXIII. Biologically active cleavage products of CTAP-III from human platelets

C W Castor  1 , D A Walz, C G Ragsdale, P A Hossler, E M Smith, M C Bignall, B P Aaron, K Mountjoy
Affiliations

Connective tissue activation. XXXIII. Biologically active cleavage products of CTAP-III from human platelets

C W Castor et al. Biochem Biophys Res Commun. .

Abstract

Evidence for three new isoforms of CTAP-III from human platelets is presented; two NH2-terminal cleavage products were identified, CTAP-III (des 1-13) and CTAP-III (des 1-15). CTAP-III (des 1-13) has a pI of 8.6 and is a relatively stable proteolytic cleavage product that retains the capacity to stimulate [14C]GAG synthesis in human synovial cell cultures. CTAP-III (des 1-15) appears to be an elastase or chymotrypsin cleavage product and identical to NAP-2, an entity thought to have neutrophil activating properties.

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