The Genetic Structure of Human Populations Studied Through Short Insertion-Deletion Polymorphisms
- PMID: 29488221
- DOI: 10.1111/j.1469-1809.2006.00287.x
The Genetic Structure of Human Populations Studied Through Short Insertion-Deletion Polymorphisms
Abstract
In a landmark study Rosenberg et al. (2002) analyzed human genome diversity with 377 microsatellites in the HGDP-CEPH Genome Diversity Panel and reported that the populations were structured into five geographical regions: America, Sub-Saharan Africa, East Asia, Oceania and a cluster composed of Europe, the Middle East and Central Asia. They also observed that the within-population component accounted for 93-95%, and that the among-regions portion was only 3.6%, of the total genetic variance. We have also studied the HGDP-CEPH Diversity Panel (1064 individuals from 52 populations) with a set of 40 biallelic slow-evolving short insertion-deletion polymorphisms (indels). We confirmed the partition of worldwide diversity into five genetic clusters that correspond to major geographic regions. Using the indels we have also disclosed an among-regions component of genetic variance considerably larger (12.1%) than had been estimated using microsatellites. Our study demonstrates that a set of 40 well-chosen biallelic markers is sufficient for the characterization of human population structure at the global level.
Keywords: DNA; genetic structure; human diversity; indels; insertion-deletion polymorphisms.
Similar articles
-
The genetic structure of human populations studied through short insertion-deletion polymorphisms.Ann Hum Genet. 2006 Sep;70(Pt 5):658-65. doi: 10.1111/j.1469-1809.2006.00287.x. Ann Hum Genet. 2006. PMID: 16907710
-
Completion of a worldwide reference panel of samples for an ancestry informative Indel assay.Forensic Sci Int Genet. 2015 Jul;17:75-80. doi: 10.1016/j.fsigen.2015.03.011. Epub 2015 Mar 25. Forensic Sci Int Genet. 2015. PMID: 25840342
-
Worldwide diversity of the Y-chromosome tetra-local microsatellite DYS464.Genet Mol Res. 2010 Aug 3;9(3):1525-34. doi: 10.4238/vol9-3gmr968. Genet Mol Res. 2010. PMID: 20690085
-
Analysis of global variability in 15 established and 5 new European Standard Set (ESS) STRs using the CEPH human genome diversity panel.Forensic Sci Int Genet. 2011 Jun;5(3):155-69. doi: 10.1016/j.fsigen.2010.02.003. Epub 2010 Mar 5. Forensic Sci Int Genet. 2011. PMID: 20457091
-
Craniometric variation, genetic theory, and modern human origins.Am J Phys Anthropol. 1994 Nov;95(3):249-70. doi: 10.1002/ajpa.1330950302. Am J Phys Anthropol. 1994. PMID: 7856764 Review.
Cited by
-
Pharmacogenomics, human genetic diversity and the incorporation and rejection of color/race in Brazil.Biosocieties. 2015 Mar 1;10(1):48-69. doi: 10.1057/biosoc.2014.21. Biosocieties. 2015. PMID: 26290677 Free PMC article.
-
Automated Genotyping of a Highly Informative Panel of 40 Short Insertion-Deletion Polymorphisms Resolved in Polyacrylamide Gels for Forensic Identification and Kinship Analysis.Transfus Med Hemother. 2012 Jun;39(3):211-216. doi: 10.1159/000338854. Epub 2012 May 11. Transfus Med Hemother. 2012. PMID: 22851937 Free PMC article.
-
Genetic features and phylogenetic relationship analyses of Guizhou Han population residing in Southwest China via 38 X-InDels.PeerJ. 2023 Mar 8;11:e14964. doi: 10.7717/peerj.14964. eCollection 2023. PeerJ. 2023. PMID: 36915656 Free PMC article.
-
Genetic variation and population structure in native Americans.PLoS Genet. 2007 Nov;3(11):e185. doi: 10.1371/journal.pgen.0030185. PLoS Genet. 2007. PMID: 18039031 Free PMC article.
-
Microsatellite Instability: From the Implementation of the Detection to a Prognostic and Predictive Role in Cancers.Int J Mol Sci. 2022 Aug 5;23(15):8726. doi: 10.3390/ijms23158726. Int J Mol Sci. 2022. PMID: 35955855 Free PMC article. Review.
LinkOut - more resources
Full Text Sources
Other Literature Sources
