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Review
. 2019 Sep 28;2019(1):183-189.
doi: 10.1093/emph/eoz026. eCollection 2019.

Human enhancement: Genetic engineering and evolution

Mara Almeida  1 , Rui Diogo  2
Affiliations
Review

Human enhancement: Genetic engineering and evolution

Mara Almeida et al. Evol Med Public Health. .

Abstract

Genetic engineering opens new possibilities for biomedical enhancement requiring ethical, societal and practical considerations to evaluate its implications for human biology, human evolution and our natural environment. In this Commentary, we consider human enhancement, and in particular, we explore genetic enhancement in an evolutionary context. In summarizing key open questions, we highlight the importance of acknowledging multiple effects (pleiotropy) and complex epigenetic interactions among genotype, phenotype and ecology, and the need to consider the unit of impact not only to the human body but also to human populations and their natural environment (systems biology). We also propose that a practicable distinction between 'therapy' and 'enhancement' may need to be drawn and effectively implemented in future regulations. Overall, we suggest that it is essential for ethical, philosophical and policy discussions on human enhancement to consider the empirical evidence provided by evolutionary biology, developmental biology and other disciplines. Lay Summary: This Commentary explores genetic enhancement in an evolutionary context. We highlight the multiple effects associated with germline heritable genetic intervention, the need to consider the unit of impact to human populations and their natural environment, and propose that a practicable distinction between 'therapy' and 'enhancement' is needed.

Keywords: enhancement; evolutionary biology; genetic engineering; genome editing; human evolution.

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References

    1. Pham P, Roux S, Matonti F. et al. Post-implantation impedance spectroscopy of subretinal micro-electrode arrays, OCT imaging and numerical simulation: towards a more precise neuroprosthesis monitoring tool. J Neural Eng 2013;10:046002. - PubMed
    1. Maghami MH, Sodagar AM, Lashay A. et al. Visual prostheses: the enabling technology to give sight to the blind. J Ophthal Vis Res 2014;9:494–505. - PMC - PubMed
    1. Weitz AC, Nanduri D, Behrend MR. et al. Improving the spatial resolution of epiretinal implants by increasing stimulus pulse duration. Sci Transl Med 2015;7:318ra203. - PMC - PubMed
    1. Bouton CE, Shaikhouni A, Annetta NV. et al. Restoring cortical control of functional movement in a human with quadriplegia. Nature 2016;533:247–50. - PubMed
    1. Geddes L. First paralysed person to be ‘reanimated’ offers neuroscience insights. Technique moves man’s arm by decoding his thoughts and electrically stimulating his own muscles. Nat News 2016;533.