Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion
- PMID: 3284962
- PMCID: PMC2188934
- DOI: 10.1084/jem.167.5.1597
Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion
Abstract
The adhesion receptors Mac-1, LFA-1, and p150,95 are cell surface alpha/beta heterodimers that play a key role in leukocyte adhesion processes. The genes for Mac-1, LFA-1, and p150,95 alpha subunits have been located to chromosome 16 by means of Southern blot analysis using a series of somatic cell hybrids. Chromosomal in situ hybridization has demonstrated that the genes for the three alpha subunits map to the short arm of chromosome 16, between bands p11 and p13.1, defining a cluster of genes involved in leukocyte adhesion. The gene encoding the LFA-1/Mac-1/p150,95 beta subunit, and defective in leukocyte adhesion deficiency, has been located on chromosome 21, band q22. The leukocyte adhesion receptor alpha and beta subunits are mapped to chromosomal regions that have been shown to be involved in cytogenetic rearrangements in certain patients with acute myelomonocytic leukemia and the blast phase of chronic myelogenous leukemia, respectively.
Similar articles
-
p150,95, the third member of the Mac-1, LFA-1 human leukocyte adhesion glycoprotein family.J Immunol. 1986 Jan;136(1):240-5. J Immunol. 1986. PMID: 3510003
-
The genetic deficiency of leukocyte surface glycoprotein Mac-1, LFA-1, p150,95 in humans is associated with defective antibody-dependent cellular cytotoxicity in vitro and defective protection against herpes simplex virus infection in vivo.J Immunol. 1986 Sep 1;137(5):1688-94. J Immunol. 1986. PMID: 3528287
-
LFA-1 immunodeficiency disease. Definition of the genetic defect and chromosomal mapping of alpha and beta subunits of the lymphocyte function-associated antigen 1 (LFA-1) by complementation in hybrid cells.J Exp Med. 1986 Sep 1;164(3):855-67. doi: 10.1084/jem.164.3.855. J Exp Med. 1986. PMID: 3528378 Free PMC article.
-
The importance of the Mac-1, LFA-1 glycoprotein family in monocyte and granulocyte adherence, chemotaxis, and migration into inflammatory sites: insights from an experiment of nature.Ciba Found Symp. 1986;118:102-26. doi: 10.1002/9780470720998.ch8. Ciba Found Symp. 1986. PMID: 3525036 Review.
-
[Regulation and therapeutic modulation of T-lymphocytes adhesion].Pathol Biol (Paris). 1992 Oct;40(8):789-92. Pathol Biol (Paris). 1992. PMID: 1484737 Review. French.
Cited by
-
Expression of LFA-1 by a lymphoblastoid cell line from a patient with monosomy 21: effects on intercellular adhesion.Clin Exp Immunol. 1990 Sep;81(3):501-6. doi: 10.1111/j.1365-2249.1990.tb05363.x. Clin Exp Immunol. 1990. PMID: 1975779 Free PMC article.
-
Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene.Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5364-8. doi: 10.1073/pnas.90.11.5364. Proc Natl Acad Sci U S A. 1993. PMID: 8099450 Free PMC article.
-
The beta subunit locus of the human fibronectin receptor: DNA restriction fragment length polymorphism and linkage mapping studies.Hum Genet. 1989 Nov;83(4):383-90. doi: 10.1007/BF00291386. Hum Genet. 1989. PMID: 2572537
-
Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.J Cell Biol. 1989 Feb;108(2):703-12. doi: 10.1083/jcb.108.2.703. J Cell Biol. 1989. PMID: 2537322 Free PMC article.
-
Comparative map for mice and humans.Mamm Genome. 1991;1 Spec No:S461-515. doi: 10.1007/BF00656504. Mamm Genome. 1991. PMID: 1799811 Review. No abstract available.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
