Comparative Study
doi: 10.1016/0167-4781(95)00034-e.
Cloning and sequence analysis of human thyroid transcription factor 1
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- PMID: 7711080
- DOI: 10.1016/0167-4781(95)00034-e
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Comparative Study
Cloning and sequence analysis of human thyroid transcription factor 1
Biochim Biophys Acta.
.
Abstract
The thyroid transcription factor 1 (TTF-1) is a homeodomain-containing transcription factor that activates the transcriptional activity of thyroid-specific gene promoters by binding to them. Hence, TTF-1 is crucial in the maintenance of the thyroid differentiation phenotype. The authors isolated and analysed the human TTF-1 gene, which shows a striking homology with the rat TTF-1 gene.
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