Effect of gastrin on pancreatic enzyme secretion and gallbladder emptying in man
- PMID: 950091
Effect of gastrin on pancreatic enzyme secretion and gallbladder emptying in man
Abstract
This study was designed to assess the effect of unsulfated synthetic human little gastrin (HG-17-I) on pancreatic secretion and gallbladder emptying in man. During continuous gastric and duodenal aspiration, 6 male subjects were given, on different days, either HG-17-I (7, 20, 60, 180 AND 540 PMOL KG-1 HR-1), chlecystokinin (0.1, 0.3, and 0.9 UKg hr-1) or 238 pmol kg-1 (500 ng kg-1) of HG-17-I as a rapid intravenous injection. Trypsin output and bilirubin output increased significantly (P less than 0.05) above basal levels during the infusion of both peptides. During HG-17-I infusion the highest trypsin output (2.08 +/- 0.22 Karmen U per 10 min) and bilirubin output (4.66 +/- 0.61 mg per 10 min) occurred during the 60 pmol kg-1 hr-1 dose, whereas highest acid output occurred during the 540 pmol kg-1 hr-1 dose. Rapid intravenous injection of HG-17-I produced a prompt and significant rise in trypsin, bilirubin, bicarbonate, and acid outputs. It is concluded that HG-17-I produced significant pancreatic enzyme secretion and gallbladder emptying at doses that are submaximal for acid secretion, suggesting that this may be a physiological effect of gastrin.
Similar articles
-
Effect of ninety-five percent pure cholecystokinin on gastrin-stimulated acid secretion in man and dog.Gastroenterology. 1979 Jul;77(1):91-5. Gastroenterology. 1979. PMID: 447032
-
The influence of hypercalcemia on basal and cholecystokinin-stimulated pancreatic, gallbladder, and gastric functions in man.Gastroenterology. 1976 Sep;71(3):405-8. Gastroenterology. 1976. PMID: 950090
-
Sham feeding and pancreatic secretion. Evidence for direct vagal stimulation of enzyme output.Gastroenterology. 1984 Jul;87(1):109-14. Gastroenterology. 1984. PMID: 6724252
-
Pancreatic, gallbladder, and gastric responses to intraduodenal calcium perfusion in man.Gastroenterology. 1976 May;70(5 PT.1):693-6. Gastroenterology. 1976. PMID: 1261760
-
Effect of gastrin on the exocrine pancreas. A review.Am J Gastroenterol. 1979 Jan;71(1):53-60. Am J Gastroenterol. 1979. PMID: 373424 Review.
Cited by
-
Hemobilia due to biliary intraepithelial neoplasia associated with Zollinger-Ellison syndrome.Clin J Gastroenterol. 2012 Jun;5(3):189-94. doi: 10.1007/s12328-012-0296-3. Epub 2012 Apr 21. Clin J Gastroenterol. 2012. PMID: 26182319
-
Effects of gastric fundectomy and antrectomy on the exocrine pancreas in the hamster.Int J Pancreatol. 1992 Oct;12(2):139-44. doi: 10.1007/BF02924637. Int J Pancreatol. 1992. PMID: 1460328
-
The Gut-Brain Axis, the Human Gut Microbiota and Their Integration in the Development of Obesity.Front Physiol. 2018 Jul 12;9:900. doi: 10.3389/fphys.2018.00900. eCollection 2018. Front Physiol. 2018. PMID: 30050464 Free PMC article. Review.
-
Pancreatic hypertrophy with acinar cell nodules after longterm fundectomy in the rat.Gut. 1993 Jul;34(7):988-93. doi: 10.1136/gut.34.7.988. Gut. 1993. PMID: 8344589 Free PMC article.
-
Effect of chronic endogenous hypergastrinaemia on pancreatic growth and carcinogenesis in the hamster.Gut. 1997 Apr;40(4):536-40. doi: 10.1136/gut.40.4.536. Gut. 1997. PMID: 9176085 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
