Innovative Approaches to Drug Discovery in Bone and Cartilage Diseases.

Introduction

Bone and cartilage diseases affect the musculoskeletal system and can lead to significant pain, disability and reduced quality of life. Innovative approaches to drug discovery and development are needed to address the unmet medical needs in this area. One promising approach is the integration of Mass Spectrometry (MS), Surface Plasmon Resonance Imaging (SPRi) and others, which enables high-throughput screening of small molecules and their interactions with musculoskeletal tissue. Pinpointing the precise targets of chemical or natural compounds in bone and cartilage diseases is also critical for optimizing their efficacy and reducing adverse effects. Preclinical studies, including toxicology and pharmacokinetics, are essential in assessing the safety profile of potential candidate drugs. The aim of this Thematic Issue is to highlight the challenges and the need for innovative approaches in drug discovery and development for bone and cartilage diseases. Developing innovative approaches to drug discovery and development in bone and cartilage diseases will improve patient outcomes and address the unmet medical needs in this area. Developing effective drugs for bone and cartilage diseases presents several challenges. One major hurdle is the need to fully understand the complex mechanisms that underlie these diseases. Additionally, researchers must identify new drug targets and develop drugs that can target specific tissues affected by these diseases. Drug delivery to affected joints and tissues is also a significant challenge that must be addressed, as is the need to ensure safety and efficacy of any new drugs developed. Ultimately, overcoming these challenges will require innovative approaches, such as the use of advanced technologies and collaborations between researchers from diverse fields. Addressing these challenges will be crucial to improving the lives of millions of people affected by bone and cartilage diseases worldwide.

Keywords

Bone and cartilage diseases, phytochemicals, natural compounds, MS, SPRi, osteoporosis, osteoarthritis, mechanisms

Sub-topics

• ??Developing innovative approaches to drug discovery and development in bone and cartilage diseases.
• Metabolism of proteins, peptides, and others in Bone and cartilage diseases.
• The integration of Mass Spectrometry (MS), Surface Plasmon Resonance Imaging (SPRi), and others.
• which enables high-throughput screening of small molecules and their interactions with musculoskeletal tissue.
• Identifying new drug targets and developing drugs that can target specific tissues affected by these diseases.
• Drug delivery to affected joints and tissues to ensure the safety and efficacy of any new drugs developed.
• Pinpointing the precise targets of chemical or natural compounds in bone and cartilage diseases for optimizing the efficacy and reducing adverse effects.
• Preclinical studies, including toxicology and pharmacokinetics, for assess the safety profile of potential candidate drugs.
• Evidence-based research on plant-based natural products is also preferred.