Diseases articles from across Nature Portfolio

A study using single-cell 3D genome mapping reveals phenotypic convergence during mouse Kras-driven lung adenocarcinoma progression and prioritizes clinically actionable driver genes. This highlights the importance of cell-to-cell variation in chromatin architecture as a determinant of cancer evolution.

Our large-scale clustering analysis identifies four reproducible subtypes of polycystic ovary syndrome, which we validated across diverse populations. These subtypes have distinct reproductive and metabolic trajectories that could guide precision management strategies.

Molecular glue degraders induce or stabilize interactions between E3 ligases and target proteins. Beyond compound-induced, direct interactions, researchers recently uncovered an allosteric mechanism whereby a drug alters the target protein’s conformation, enabling high-affinity neo-binding to an E3 ligase and triggering degradation.

This PrimeView highlights the epidemiology and our current understanding of the pathophysiology of Schizophrenia as well as discusses its diagnosis and management.

Schizophrenia is a complex and often long-lasting mental health condition that typically begins in late adolescence. In this Primer, Leucht and colleagues review the epidemiology of schizophrenia and current understanding of its pathophysiology, diagnosis and treatment, and discuss the quality of life of affected individuals as well as future research directions.

Parkinson’s disease (PD) is not a single disease but a diverse syndrome with varied biological mechanisms, symptoms, and trajectories. Outdated stereotypes and one-size-fits-all approaches to disease-modifying therapies have stymied progress in research, and public understanding. Emerging efforts in biomarker-based subtyping and precision medicine emphasize personalized methods tailored to an individual’s biology. Progress requires research includes all segments of the patient population and the understanding that the cure is personalized.

A study using single-cell 3D genome mapping reveals phenotypic convergence during mouse Kras-driven lung adenocarcinoma progression and prioritizes clinically actionable driver genes. This highlights the importance of cell-to-cell variation in chromatin architecture as a determinant of cancer evolution.