Gastroenterology articles from across Nature Portfolio

A new case report of successful treatment of refractory ulcerative colitis with CD19-directed chimeric antigen receptor T cell therapy sheds light on the role of B lineage cells in disease pathogenesis and the possibility of an ‘immune reset’. This approach could reshape therapeutic strategies, although its long-term efficacy, safety and positioning remain open questions.

A new study in mice links ethanol consumption to endogenous fructose generation via hepatic aldose reductase, which enhances alcohol-seeking behaviour and liver damage. Inhibition of ketohexokinase reduced these effects, highlighting potential targets for managing alcohol use disorders.

The year 2025 has seen substantial advances in the understanding and management of metabolic dysfunction-associated steatotic liver disease, providing new insights into its systemic effects. Emerging evidence in 2025 supports integrated heart–liver co-management, translating the concept into actionable clinical strategies.

Despite more women entering medicine, women in gastroenterology continue to experience disparities in training, research and career opportunities. United European Gastroenterology calls to ensure that everyone has equal access to opportunities, mentoring and supportive workplaces that will benefit both professionals and patients.

A new case report of successful treatment of refractory ulcerative colitis with CD19-directed chimeric antigen receptor T cell therapy sheds light on the role of B lineage cells in disease pathogenesis and the possibility of an ‘immune reset’. This approach could reshape therapeutic strategies, although its long-term efficacy, safety and positioning remain open questions.

Patients with pancreatic exocrine insufficiency are treated with pancreatic enzyme replacement therapy. However, there are several challenges facing the future of this treatment, including infectious agents and the presence of microplastics and nanoplastics.

A preprint by Rivera et al. explores how retroelement expression establishes a tolerogenic environment towards food antigens in the gut, shedding new insights into the immune regulatory role of retroelements.

A new study in mice links ethanol consumption to endogenous fructose generation via hepatic aldose reductase, which enhances alcohol-seeking behaviour and liver damage. Inhibition of ketohexokinase reduced these effects, highlighting potential targets for managing alcohol use disorders.