Transcriptomics articles from across Nature Portfolio

A large consortium of researchers has mapped how brain cells establish diverse identities throughout neurodevelopment and across species.

This study shows how the links between somatic passenger mutations in tumors and normal cell transcriptomes can be used to infer cell-of-origin in lung adenocarcinoma.

Single nuclei RNA sequencing of the ob/ob mouse hippocampus uncovers cell type- and sex-specific obesity-induced alterations in the neurovascular unit transcriptome, with implications for obesity-associated cognitive decline.

The evolution of cutaneous squamous cell carcinoma (cSCC) remains poorly understood. Here, the authors employ multi-omics and multi-scale analyses to explore the genetic evolution of keratinocytes to cSCC, finding key pathogenic mutations that break the resistance to ultraviolet radiation as well as spatial heterogeneity patterns.

Yuan et al. present S2-omics, an end-to-end workflow that automatically identifies regions of interest in histology images to maximize molecular information capture in spatial omics experiments.

The clinical outcomes and treatment responses of acute myeloid leukemia (AML) patients are heterogeneous. Here, the authors use bulk and single-cell sequencing approaches and identify two transcriptomic subtypes within NPM1-mutated AML with distinct immune evasion properties and responses to hematopoietic stem cell transplantation.

A large consortium of researchers has mapped how brain cells establish diverse identities throughout neurodevelopment and across species.

In amyotrophic lateral sclerosis (ALS), nuclear depletion and cytoplasmic aggregation of the RNA-binding protein TDP-43 cause widespread dysregulation of mRNA splicing. Two recent studies have now revealed that loss of TDP-43 also affects mRNA 3′ end cleavage and polyadenylation, further influencing mRNA metabolism and protein expression.

Latin American–Caribbean single-cell genomics initiatives are generating inclusive AI-ready data for precision medicine, and empowering the region’s scientists to become researcher leaders.

This Comment posits that enhancers stimulate the transcription machinery only through short-range interactions and, therefore, that enhancer activity at a distance is mediated by chromatin loops between distal and proximal enhancers, not between enhancers and promoters.