Regulated Fluctuations in Nanog Expression Mediate Cell Fate Decisions in Embryonic Stem Cells
Figure 7
Stochastic simulation of the GRN associated with pluripotency.
(A, C, and E) Profiles, resulting from stochastic simulations of the GRN shown in Figure 3, emerging from single cells with increasing levels of noise. (B, D, and F) Trajectories of single cells in the regimes indicated above. For details of the model, see Protocol S1. Notice that increasing the noise (by reducing the effective volume of the cell) increases the width of the peak of low expression.