deFuse: An Algorithm for Gene Fusion Discovery in Tumor RNA-Seq Data
Figure 7
a) Read depth across HNF1A exonic positions shows that only the region after the fusion boundary is being expressed, evidence of the possible biallelic inactivation of HNF1A. b) Putative RREB1-TFE3 chimeric protein showing preservation of TFE3's basic helix-loop-helix (bHLH) leucine zipper (LZ) domain and N-terminal activation domain (ATA), in addition to 4 of RREB1's zinc finger (ZF) motifs.