The Extracellular Domain of Neurotrophin Receptor p75 as a Candidate Biomarker for Amyotrophic Lateral Sclerosis
Figure 4
Receiver Operating Characteristic curves for distinguishing ALS patients from A. healthy controls and B. patients with other neurological conditions (OND) using p75NTRECD.
A The area under the curve (AUC) indicated ALS patients are distinguished from controls 100% of time (AUC: 1.0) with a 95% confidence interval of 1. B. In comparison, ALS was distinguished from OND (Parkinson's and Multiple Sclerosis) 96% of time, with a 95% confidence interval of 0.9 to 1.1. The cut-off value for distinguishing ALS patients from healthy controls, using the Youden index (Baker and Krame, 2007) was >4.8 and from OND >4.8 (ng p75NTRECD/mg creatinine).