Research articles

Earth system models often categorize plants to just a few functional types, and plant characteristics are defined per type, neglecting their diversity. The authors show how the use of plant traits can improve the modeling of global carbon, water, and energy fluxes

Pathological B-cell receptor (BCR) signaling is a key driver of mantle cell lymphoma tumorigenesis. Here, the authors discover that CEACAM1, an immunoglobulin-like transmembrane protein, is essential for a subset of mantle cell lymphoma through activation of the BCR.

Circulating metabolites reflect complex disease risk and are shaped by diverse genetic factors. Here, the authors show widespread pleiotropy across 249 metabolic traits, identify rare variant and sex-specific effects, and implicate lipid-related pathways in metabolism.

Epidemiological and experimental evidence reveals that dietary advanced glycation end-products (AGEs) promote food allergy development. The authors demonstrate through multiple experimental models that AGE-rich diets increase allergic inflammation and Th2 immune responses and impaired intestinal barrier function through RAGE-TLR4 signalling crosstalk.

Loss of RNF20 is associated with aggressive cancer phenotypes. Here the authors show that Rnf20 haploinsufficiency leads to the formation of lung tumours due to defective DNA repair and HIF1α-mediated metabolic rewiring.

Deep brain stimulation of the basal ganglia restores cognitive flexibility and rebalances exploration disrupted by NMDA receptor antagonism in nonhuman primates, offering insights into the neural basis of psychosis and a potential treatment for schizophrenia.

Glioma stem-like cells (GSCs) contribute to therapeutic resistance via enhanced capability of DNA damage repair. Here the authors identify that the upregulated transcription factor AATF in GSCs modulates the stability and release of XRCC4 protein to promote DNA repair and resistance to radiotherapy.

How Meckel-Gruber syndrome protein TMEM67 functions in ciliogenesis and Wnt signaling simultaneously is unknown. Here the authors show that TMEM67 is proteolytically cleaved by the matrix metalloproteinase ADAMTS9 generating two functional isoforms.

A two-step Bayesian model improves small area population estimates by integrating health campaign data or household surveys with incomplete satellite settlement maps. It reduces errors by up to 73%, offering a practical solution in regions where traditional methods face limitations.

Asynchronous and interferometric transient absorption is used to spectroscopically investigate perovskite nanomaterials undergoing light-induced reactions during measurements, monitoring the associated real-time ultrafast photophysical changes of materials.

Wheat stem rust resistance gene Sr6-mediated resistance is enhanced at lower temperatures whereas Sr13 and Sr21 resistances are enhanced at higher temperatures. Here, the authors clone Sr6 and show the divergent molecular pathways governing temperature-dependent resistance among these genes.

Transcranial focused ultrasound can be used for neuromodulation, but its use in wearable systems remains challenging. The authors present a miniaturised wearable ultrasound device, integrated with a bioadhesive hydrogel for stable, long-term somatosensory cortical stimulation.

In this work, authors develop obex inhibitors that target a distinct binding pocket in the ATPase domain of Topoisomerase II. They demonstrate how Topobexin, a Topoisomerase IIβ - selective catalytic inhibitor, blocks conformational changes and protects against anthracycline cardiotoxicity.

Here, the authors characterize how different dietary components lead to functional alterations in the gut symbiont Bacteroides thetaiotaomicron, showing effects on the orientation of phase variable regions in humans, in vivo, and in vitro, and on modulating the bacterium´s proteome and immune-modulatory functionality.

While BH3-mimetics can be effective for treatment of haematological malignancies, their efficacy in solid tumours is limited. Here, using a range of patient-derived prostate cancer models, the authors demonstrate that increased replication stress induced by RB1 loss confers sensitivity to BH3 mimetics targeting BCL-XL.

The mechanical stability of catalytic electrodes is crucial for anion exchange membrane water electrolysis. Here, the authors report a corrosion strategy to construct an electrode with high mechanical stability by anchoring a blade-shaped catalytic layer onto a dense interlayer.

Liver transplant recipients are at risk of graft injury, yet diagnosis currently relies on invasive biopsies with associated risks. Here the authors developed and validated a non-invasive AI model, GraftIQ, which integrates clinician expertise with machine learning to accurately predict graft pathology and support clinical decision-making.

Conventional stretchable circuit fabrication requires complex packaging to prevent leakage. Here the authors introduce a self packaging stretchable circuit enabled by in situ sintering of ligand-bound liquid metal particles, allowing scalable, leakage-free, multilayer integration.