News & Comment

A preprint by Liu et al. shows proof-of-concept for a treatment for autoimmune diseases such as SLE using synthetic immune receptor T cells that target 9G4 idiotope B cells.

A preprint by Bockman et al. reports a cDC2-CD4⁺ T cell axis that mediates local tumour control after ablation of intratumoral T_reg cells, without eliciting autoimmunity.

A preprint by Zhijie et al. identifies somatic mutations in TYK2 that are enriched in tumour-infiltrating lymphocytes and associated with an increased antitumour response.

This poster provides an overview of the current subset-based nomenclature for T cells and a newly proposed modular nomenclature for T cells. It is based on the 2025 consensus statement Guidelines for T cell nomenclature.

Short-chain fatty acids generated by the gut microbiota can support T cell ‘stemness’ and lead to improved cancer immunotherapy outcomes.

A preprint by Guo et al. reports a mechanism of transcriptional control of RORγt expression in intestinal antigen-presenting cells that are important for oral tolerance involving the cis-regulatory region OCR369.

A preprint by Srinivasan et al. describes the role of the gut microbiota and serum amyloid A in regulating retinoid flux that is important for myeloid cell migration and T cell priming.

A preprint by Rivera et al. explores how retroelement expression establishes a tolerogenic environment towards food antigens in the gut, shedding new insights into the immune regulatory role of retroelements.

A preprint by Sadiku et al. characterizes neutrophil diversity in glioblastoma using a new workflow for single-cell proteomic profiling.

Lipid transport regulates activation of intestinal T helper 17 cells and thereby limits dietary fat absorption and diet-induced weight gain.

Sanchez-Garcia et al. report that systemic hypoxia-induced epigenetic reprogramming of neutrophil progenitors in the bone marrow reduces their effector function to limit lung tissue damage.

Amyotrophic lateral sclerosis is associated with CD4⁺ T cells that are specific for the C9orf72 autoantigen and preferentially produce IL-4, IL-5 and IL-10.

Group 2 innate lymphoid cells are crucial for maintaining nerve structure and pain thresholds.

A proteotoxic stress response specific to exhausted T cells represents a target for cancer immunotherapy.

Depending on context and concentration, the polyamine cadaverine can promote pro- or anti-inflammatory macrophage polarizations.

A study in Science Immunology reports that regulatory T cells in the skin modulate neuronal tone directly through their production of the opioid enkephalin.

Many patients with cancer who could potentially benefit from treatment with chimeric antigen receptor (CAR)-T cells do not have access to this therapy. This Comment explores the unique barriers to a broader clinical adoption of CAR-T cell therapy and propose new routes to improve timely and equitable access to treatment.

Populations of regulatory KIR⁺CD8⁺ T cells expand during pregnancy and can promote maternal tolerance to the developing fetus.

B cells that expand following infection with EBV can colonize the brain, where they recruit activated T cells that have potential to cause neuronal damage, thereby providing a mechanism to explain the link between EBV and increased MS risk.

A study by Bhattarai et al. in Nature Immunology reports that ILC3-to-ILC1 plasticity in the gut is regulated by circadian clock proteins.