Biochemistry articles from across Nature Portfolio

Biochemistry is the study of the structure and function of biological molecules such as proteins, nucleic acids, carbohydrates and lipids. Biochemistry is also used to describe techniques suited to understanding the interactions and functions of biological molecules, including traditional techniques such as Western blotting, co-immunoprecipitation, and chromatography methods.

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Gluing the allosteric way

Molecular glue degraders induce or stabilize interactions between E3 ligases and target proteins. Beyond compound-induced, direct interactions, researchers recently uncovered an allosteric mechanism whereby a drug alters the target proteinâ€™s conformation, enabling high-affinity neo-binding to an E3 ligase and triggering degradation.
- Laura A. Schneider
- Alexandra M. Bendel
- Nicolas H. ThomÃ¤
News & Views21 Nov 2025 Nature Chemical Biology
Volume: 21, P: 1835-1836
Triplet quenchers for energy-transfer photobiocatalysis

Engineering protein catalysts represents an attractive approach for enantioselective energy-transfer photochemistry. By combining a genetically encoded photosensitizer in the protein catalyst and a judiciously selected triplet quencher to suppress the racemic background reaction in the solution, photobiocatalytic [2+2] cycloaddition offers improved enantiocontrol in a triplet sensitization catalysis.
- Wenzhen Fu
- Yang Yang
News & Views21 Nov 2025 Nature Catalysis
Volume: 8, P: 1131-1132
iAutoEvoLab as an all-in-one laboratory for programmable protein evolution

iAutoEvoLab is an industrial-grade automation platform for the growth-coupled, continuous evolution of proteins in yeast. Its high throughput, efficiency and effectiveness were demonstrated by the evolution of a DNA-binding protein (LmrA), a lactate sensor (LldR) and a RNA polymeraseâ€“capping enzyme fusion protein.

News & Views20 Nov 2025 Nature Chemical Engineering
Volume: 2, P: 670-671

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Latest Research and Reviews

Catalytic activity of FAHD1 correlates with nuclear morphology and proteomic states in human osteosarcoma cells
- Andreas S. Pfarl
- Anne Heberle
- Alexander K. H. Weiss
ResearchOpen Access25 Nov 2025 Scientific Reports
P:
Evaluation of antibacterial and cytotoxic effects of silver oxide nanoparticles synthesized from Psidium Guajava
- Abdullah Yousef
- Salem S. Salem
- Rania Hamed Elbawab
ResearchOpen Access25 Nov 2025 Scientific Reports
P:
Role of HMGB1 in ischemia/reperfusion injury in a rat model of myocardial infarction
- Martina Cebova
- Andrej Barta
- Olga Pechanova
ResearchOpen Access25 Nov 2025 Scientific Reports
P:
Fluorescence spectroscopy combined with molecular docking to study the interaction between folic acid derivatives from wheat grains and bovine trypsin
- Peng Tian
- Yuchen Jia
- Shuiyuan Hao
ResearchOpen Access25 Nov 2025 Scientific Reports
P:
Recent advances in lincosamide biosynthetic studies
- Yi Yang
- Takahiro Mori
ReviewsOpen Access25 Nov 2025 The Journal of Antibiotics
P: 1-12
Synthesis, antiproliferative screening, and molecular docking of some heterocycles derived from N-(1-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-3-hydrazineyl-3-oxoprop-1-en-2-yl)benzamide
- Eman A. E. El-Helw
- Youssef M. Youssef
- Mohammad E. Azab
ResearchOpen Access24 Nov 2025 Scientific Reports
P:

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News and Comment

Gluing the allosteric way

Molecular glue degraders induce or stabilize interactions between E3 ligases and target proteins. Beyond compound-induced, direct interactions, researchers recently uncovered an allosteric mechanism whereby a drug alters the target proteinâ€™s conformation, enabling high-affinity neo-binding to an E3 ligase and triggering degradation.
- Laura A. Schneider
- Alexandra M. Bendel
- Nicolas H. ThomÃ¤
News & Views21 Nov 2025 Nature Chemical Biology
Volume: 21, P: 1835-1836
Triplet quenchers for energy-transfer photobiocatalysis

Engineering protein catalysts represents an attractive approach for enantioselective energy-transfer photochemistry. By combining a genetically encoded photosensitizer in the protein catalyst and a judiciously selected triplet quencher to suppress the racemic background reaction in the solution, photobiocatalytic [2+2] cycloaddition offers improved enantiocontrol in a triplet sensitization catalysis.
- Wenzhen Fu
- Yang Yang
News & Views21 Nov 2025 Nature Catalysis
Volume: 8, P: 1131-1132
iAutoEvoLab as an all-in-one laboratory for programmable protein evolution

iAutoEvoLab is an industrial-grade automation platform for the growth-coupled, continuous evolution of proteins in yeast. Its high throughput, efficiency and effectiveness were demonstrated by the evolution of a DNA-binding protein (LmrA), a lactate sensor (LldR) and a RNA polymeraseâ€“capping enzyme fusion protein.

News & Views20 Nov 2025 Nature Chemical Engineering
Volume: 2, P: 670-671
Expansion of artificial intelligence for genome editing

Artificial intelligence (AI) is advancing genome editing, from predictive modeling to generative design. Emerging generative AI tools such as RFdiffusion, AlphaFold 3 and ESM now facilitate the de novo design of linkers, inhibitors and enzymes. We highlight work where AI-driven design is used to enhance the precision of mitochondrial cytosine base editors.
- Heesoo Uhm
- Sangsu Bae
News & Views20 Nov 2025 Nature Structural & Molecular Biology
P: 1-3
Exchange coupling
- Grant Miura
Research Highlights17 Nov 2025 Nature Chemical Biology
Volume: 21, P: 1832
Why I moved my research to China from Germany: a biologistâ€™s experience

Shaw prizewinner Wolfgang Baumeister is one of many international researchers recruited by Chinese institutes.
- Rachel Fieldhouse
News14 Nov 2025 Nature

All News & Comment

Biochemistry articles from across Nature Portfolio

Featured

Gluing the allosteric way

Triplet quenchers for energy-transfer photobiocatalysis

iAutoEvoLab as an all-in-one laboratory for programmable protein evolution

Related Subjects

Latest Research and Reviews

Catalytic activity of FAHD1 correlates with nuclear morphology and proteomic states in human osteosarcoma cells

Evaluation of antibacterial and cytotoxic effects of silver oxide nanoparticles synthesized from Psidium Guajava

Role of HMGB1 in ischemia/reperfusion injury in a rat model of myocardial infarction

Fluorescence spectroscopy combined with molecular docking to study the interaction between folic acid derivatives from wheat grains and bovine trypsin

Recent advances in lincosamide biosynthetic studies

Synthesis, antiproliferative screening, and molecular docking of some heterocycles derived from N-(1-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-3-hydrazineyl-3-oxoprop-1-en-2-yl)benzamide

News and Comment

Gluing the allosteric way

Triplet quenchers for energy-transfer photobiocatalysis

iAutoEvoLab as an all-in-one laboratory for programmable protein evolution

Expansion of artificial intelligence for genome editing

Exchange coupling

Why I moved my research to China from Germany: a biologistâ€™s experience

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