A Blessed Merry Christmas and A Prosperous New Year To All!!!!
A Blessed Merry Christmas and A Prosperous New Year To All!!!!
Department of Biochemistry
LECTURES:
Glycogenolysis & Gluconeogenesis
Lipid Chemistry & Digestion
Lipogenesis (Fatty Acid & TAG Synthesis)
Cholesterol & Lipoprotein Metabolism
Eicosanoid Metabolism
Ketogenesis & β-oxidation
BGD on Carbohydrate Metabolism
LABORATORY
Lipid Profile/BGD Journals
32. Which enzyme would be needed to transport TAGs from the liver to the blood?
A. MTP B .LCAT C. GPAT D.ACAT
34. Which enzyme’s product removes the inhibitory effect on FA oxidation when ↑AMP?
A. acetyl CoA carboxylase (ACC1) C. HMG CoA synthase (HMGS)
B. malonyl CoA decarboxylase (MCAD) D. HMGCoA reducatse (HMGR)
38. What process will release palmitate from fatty acid synthase (FAS)?
A. decarboxylation B. dehydration C. hydrolysis D. reduction
39. In the fed state, what will be the biological activity :covalent modification pair of ACC1?
A. active: dimerization C. active: polymerization
B. inactive: dimerization D. inactive: polymerization
40. If fructose is the precursor, which intermediate is the direct source of the TAGs backbone?
A. dihydroxyacetone (DHA) C. Glyceraldehyde (GAD)
B. dihydroxyacetone phosphate (DHAP) D. Glyceraldehyde 3-PO4 (GADP)
41. In the fed state, what is the apolipoprotein stimulator: activated enzyme pair on the adipocyte?
A. apoB48: HSL B. apoB48: LPL C. apoC II :HSL D. . apoC II : LPL
42. What is the covalent modification of acetyl CoA carboxylase 1 (ACC1) in the FED state?
A. acetylation B. deacetylation C. dephosphorylation D. phosphorylation
44. Which of the following enhances secretion of insulin by the islet cells of the pancreas?
A. FADH2 B. NADH C. NADPH
45. What is the covalent modification on hormone sensitive lipase in response to glucagon in the adipocyte?
A. acetylation B. deacetylation C. dephosphorylation D. phosphorylation
46. Which molecule activates fatty acid synthase (FAS)?
A. acetyl CoA B. malonyl CoA C. NADH D. NADPH
50. Palmitoyl CoA will have which covalent modification effect on ACC1?
A. carboxylation B. decarboxylation C. dephosphorylation D. phosphorylation
51. What is the most common product of fatty acid synthesis in humans?
A. 16C: 0 C. 18C: 0 D. 22C:0
52. What fatty acid is the most common product of elongation from FA de novo synthesis?
A. 18C: 0 B. 18 C: 1 9 C. 16C: 0 D. 16C: 1 9
53. Which biochemical process will malic enzyme catalyze to generate NADPH?
A. carboxylation B. decarboxylation C. dephosphorylation D. phosphorylation
55. Which lipase would supply glycerol to the liver during FASTED state?
A. ATGL B. HTGL C. HSL D. LPL
UNIVERSITY OF THE EAST
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, INC.
DEPARTMENT OF BIOCHEMISTRY
32. Which enzyme would be needed to transport TAGs from the gut to the blood?
A. MTP B .LCAT C. GPAT D.ACAT
38. What process will release palmitate from fatty acid synthase (FAS)?
A. decarboxylation B. dehydration C. hydrolysis D. reduction
39. In the fed state, what will be the biological activity :covalent modification pair of ACC1?
A. active: dimerization C. active: polymerization
B. inactive: dimerization D. inactive: polymerization
40. If glucose is the precursor, which intermediate is the direct source of the TAGs backbone?
A. dihydroxyacetone (DHA) C. Glyceraldehyde (GAD)
B. dihydroxyacetone phosphate (DHAP) D. Glyceraldehyde 3-PO4 (GADP)
41. In the fed state, What is the apolipoprotein stimulator: activated enzyme pair on the adipocyte?
A. apoB48: HSL B. apoB48: LPL C. apoC II :HSL D. . apoC II : LPL
42. What is the covalent modification of acetyl CoA carboxylase 1 (ACC1) in the FED state?
A. acetylation B. deacetylation C. dephosphorylation D. phosphorylation
44. Which of the following enhances secretion of insulin by the islet cells of the pancreas?
A. FADH2 B. NADH C. NADPH
45. What is the covalent modification on hormone sensitive lipase in response to glucagon in the adipocyte?
A. acetylation B. deacetylation C. dephosphorylation D. phosphorylation
46. Which molecule activates fatty acid synthase (FAS)?
A. acetyl CoA B. malonyl CoA C. NADH D. NADPH
50. Palmitoyl CoA will have which covalent modification effect on ACC1?
A. carboxylation B. decarboxylation C. dephosphorylation D. phosphorylation
51. What is the most common product of fatty acid synthesis in humans?
A. 10C: 0 B: 16C: 0 C. 18C: 0 D. 22C:0
52. What fatty acid is the most common product of elongation in the endoplasmic reticulum?
A. 18C: 0 B. 18 C: 1 9 C. 16C: 0 D. 16C: 1 9
53. Which biochemical process will malic enzyme catalyze to generate NADPH?
A. carboxylation B. decarboxylation C. dephosphorylation D. phosphorylation
55. Which lipase would supply glycerol to the liver during FASTED state?
A. ATGL B. HTGL C. HSL D. MGL
UNIVERSITY OF THE EAST
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, INC.
DEPARTMENT OF BIOCHEMISTRY
32. Dietary lipids like triacylglycerol (TAGs) are packaged and transported within the gut with which of the following?.
A. bile salts B. chylomicrons C. VLDL
33. Which enzyme would be needed to transport TAGs from the gut to the blood?
A. MTP B .LCAT C. GPAT D.ACAT
34. What is the most common product of fatty acid synthesis in humans?
A. 10C: 0 B: 16C: 0 C. 18C: 0 D. 22C:0
38. What process will release palmitate from fatty acid synthase (FAS)?
A. decarboxylation B. dehydration C. hydrolysis D. reduction
39. In the fed state, what will be the biological activity :covalent modification pair of ACC1?
A. active: dimerization C. active: polymerization
B. inactive: dimerization D. inactive: polymerization
40. If glucose is the precursor, which intermediate is the direct source of the TAGs backbone?
A. dihydroxyacetone (DHA) C. Glyceraldehyde (GAD)
B. dihydroxyacetone phosphate (DHAP) D. Glyceraldehyde 3-PO4 (GADP)
41. In the fed state, What is the apolipoprotein stimulator: activated enzyme pair on the adipocyte?
A. apoB48: HSL B. apoB48: LPL C. apoC II :HSL D. . apoC II : LPL
42. What is the covalent modification of acetyl CoA carboxylase 1 (ACC1) in the FED state?
A. acetylation B. deacetylation C. dephosphorylation D. phosphorylation
43. Which lipase would supply glycerol to the liver during FASTED state?
A. ATGL B. HTGL C. HSL D. MGL
45. Which of the following enhances secretion of insulin by the islet cells of the pancreas?
A. FADH2 B. NADH C. NADPH
46. What is the covalent modification on hormone sensitive lipase in response to glucagon in the adipocyte?
A. acetylation B. deacetylation C. dephosphorylation D. phosphorylation
47. Which molecule activates fatty acid synthase (FAS)?
A. acetyl CoA B. malonyl CoA C. NADH D. NADPH
52. Palmitoyl CoA will have which covalent modification effect on ACC1?
A. carboxylation B. decarboxylation C. dephosphorylation D. phosphorylation
53. What fatty acid is the most common product of elongation in the endoplasmic reticulum?
A. 18C: 0 B. 18 C: 1 9 C. 16C: 0 D. 16C: 1 9
54. Which biochemical process will malic enzyme catalyze to generate NADPH?
A. carboxylation B. decarboxylation C. dephosphorylation D. phosphorylation
Match the intrinsic apo LP in column A with the LP in Column B. . Choices may be used more than once or not at all.
Column A Column B
B 61. apoA A. chylomicrons
A 62. apoB48 B. HDL
C/D/E 63. apoB100 C. IDL
B 64. apoCII D. LDL
B 65. apoE E. VLDL
Match the LP in column A with the predominant content in Column B. . Choices may be used more than once or not at all.
Column A Column B
A 66. HDL A. proteins
B 67.VLDL B. TAGs
D 68. IDL C. FC and CE (cholesteryl ester)
C 69. LDL D. B &C
B 70. Chylomicrons
72. Which process is involved in the cpnversion of cholesterol for fecal excretion??
A. reduction B. hydroxylation C. dehydroxylation
73. Which process is involved in the conversion of cholesterol to primary bile salt?
A. reduction B. hydroxylation C. dehydroxylation
74. Which gene specific transcription factor is directly inactivated by increased blood oxysterols?
A. LXR B. RXR C. SREBP-1c
75. Which drugs will inhibit Nieman Pick C1-like 1 protein function?
A. statins B. resins C. fibrate D. ezetimibe
Match the LP in column A with the intrinsic apoLP in Column B. . Choices may be used more than once or not at all.
Column A Column B
A 61. HDL A. apoA
C 62. VLDL B. apoB48
C 63. IDL C. apoB100
C 64. LDL
B 65. Chylomicrons
Match the LP in column A with the predominant content in Column B. . Choices may be used more than once or not at all.
Column A Column B
A 66. HDL A. proteins
B 67.VLDL B. TAGs
D 68. IDL C. FC and CE
C 69. LDL D. B &C
B 70. Chylomicrons
72. Which process is involved in the cpnversion of cholesterol for fecal excretion??
A. dehydration B. dihydroxylation C. hydroxylation D. reduction .
73. Which position is involved in the conversion of cholesterol to primary bile salts?
A. 3 B. 5 C. 7 D.12
74. Which gene specific transcription factor is directly inactivated by increased blood oxysterols?
A. LXR B. RXR C. SREBP-1c
75. Which drugs will inhibit Nieman Pick C1-like 1 protein function?
A. statins B. resins C. fibrate D. ezetimibe
Match the intrinsic apo LP in column A with the LP in Column B. . Choices may be used more than once or not at all.
Column A Column B
B 61. apoA A. chylomicrons
A 62. apoB48 B. HDL
C/D/E/63. apoB100 C. IDL
B 64. apoCII D. LDL
B 65. apoE E. VLDL
Match the LP in column A with the predominant content in Column B. Choices may be used more than once or not at all.
Column A Column B
A 66. HDL A. proteins
B 67.VLDL B. TAGs
D 68. IDL C. FC and CE (cholesteryl ester)
C 69. LDL D. B &C
B 70. Chylomicrons
72. Which gene specific transcription factor is directly inactivated by increased blood oxysterols?
A. LXR B. RXR C. SREBP-1c
73. Which drugs will inhibit Nieman Pick C1-like 1 protein function?
A. statins B. resins C. fibrate D. ezetimibe
79. According to Statins are expected to lower his cholesterol levels by a MAXIMUM of which %?
A. 80 B. 70 C. 60 D. 50
80. Which process is involved in the conversion of cholesterol for fecal excretion??
A. reduction B. hydroxylation C. dehydroxylation
UNIVERSITY OF THE EAST
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, INC.
DEPARTMENT OF BIOCHEMISTRY
Quiz # 5: β-OXIDATION & KETOGENESIS
first 20/2= 10 x12= 120 ATP via KReb cycle, no of spirals is 9 x 5= 45 minus 2 so 163
82. The oxidation of a fatty acid with an Odd number of carbon atoms yields: acetyl coa plus:
A. propionyl CoA B. malonyl CoA C. palmitoyl CoA D. trans enoyl CoA.
85. Which of the following enzyme: product pair is correct in the beta oxidation of LCFA?
A. AcylCoA dehydrogenase: L-β hydroxyacylCoA
B. β- hydroxyacylCoA dehydrogenase :β keto acyl CoA
C. EnoylCoA hydratase: fatty acyl coa
D. β keto thiolase: trans fatty enoyl CoA
UNIVERSITY OF THE EAST
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, INC.
DEPARTMENT OF BIOCHEMISTRY
Quiz # 5: β-OXIDATION & KETOGENESIS
It is also called acyl CoA synthetase, I, It only activates LCFA not VLCFA, it is at the inner mitochondrial membrane and
peroxisomal membranest is presenet in the ER
84. How many Acetyl CoA is produced by the oxidation of LINOLEIC ACID?
A. 7 B. 8 C.9 D. 10
82. The only glucoeogenic portion of C19 FA enters the TCA via which intermediate?
A.Succinyl CoA C. alpha ketoflutarate
B. Isocitrate D. malate
84. Compared to adults, which would explain the early onset ketosis in children?
A. ↑Muscle, ↑adipose tissue C. ↓Muscle, ↑adipose tissue
B. ↓Muscle, ↓ adipose tissue D.↑ Muscle, ↓adipose tissue