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A Blessed Merry Christmas and A Prosperous New Year To All!!!!

This document contains two quizzes on lipogenesis for biochemistry students at the University of the East Ramon Magsaysay Memorial Medical Center. The quizzes have 55 multiple choice questions each testing knowledge of key concepts in lipid metabolism including fatty acid synthesis, elongation, desaturation, and regulation. It also provides the date and section for each quiz.

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0% found this document useful (0 votes)
69 views

A Blessed Merry Christmas and A Prosperous New Year To All!!!!

This document contains two quizzes on lipogenesis for biochemistry students at the University of the East Ramon Magsaysay Memorial Medical Center. The quizzes have 55 multiple choice questions each testing knowledge of key concepts in lipid metabolism including fatty acid synthesis, elongation, desaturation, and regulation. It also provides the date and section for each quiz.

Uploaded by

Manila Med
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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University of the East

RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, INC


College of Medicine

Department of Biochemistry

THIRD LONG EXAM TOPICS (DECEMBER 3, 2018):

LECTURES:
Glycogenolysis & Gluconeogenesis
Lipid Chemistry & Digestion
Lipogenesis (Fatty Acid & TAG Synthesis)
Cholesterol & Lipoprotein Metabolism
Eicosanoid Metabolism
Ketogenesis & β-oxidation
BGD on Carbohydrate Metabolism
LABORATORY
Lipid Profile/BGD Journals

A BLESSED MERRY CHRISTMAS AND A


PROSPEROUS NEW YEAR TO ALL!!!!
UNIVERSITY OF THE EAST
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, INC.
DEPARTMENT OF BIOCHEMISTRY

Quiz # 4.1 : LIPOGENESIS

NAME: _____________________________________ SECTION A DATE: _____________


CHOOSE THE BEST ANSWER.
31. Dietary lipids like triacylglycerol (TAGs) are packaged and transported within the gut with which of the following?.
A. bile salts B. chylomicrons C. VLDL

32. Which enzyme would be needed to transport TAGs from the liver to the blood?
A. MTP B .LCAT C. GPAT D.ACAT

33. What is the committed enzyme in lipogenesis?


A. acetyl CoA carboxylase (ACC1) C. HMG CoA synthase (HMGS)
B. malonyl CoA decarboxylase (MCAD) D. HMGCoA reducatse (HMGR)

34. Which enzyme’s product removes the inhibitory effect on FA oxidation when ↑AMP?
A. acetyl CoA carboxylase (ACC1) C. HMG CoA synthase (HMGS)
B. malonyl CoA decarboxylase (MCAD) D. HMGCoA reducatse (HMGR)

35. What is the reducing equivalent required in palmitate synthesis?


A. FADH B. NADH C. NADPH

36. What is the reducing equivalent required for palmitate elongation?


A. FADH B. NADH C. NADPH

37. What is the reducing equivalent required for a 10C elongation?


A. NADPH B. NADH C. both

38. What process will release palmitate from fatty acid synthase (FAS)?
A. decarboxylation B. dehydration C. hydrolysis D. reduction

39. In the fed state, what will be the biological activity :covalent modification pair of ACC1?
A. active: dimerization C. active: polymerization
B. inactive: dimerization D. inactive: polymerization

40. If fructose is the precursor, which intermediate is the direct source of the TAGs backbone?
A. dihydroxyacetone (DHA) C. Glyceraldehyde (GAD)
B. dihydroxyacetone phosphate (DHAP) D. Glyceraldehyde 3-PO4 (GADP)

41. In the fed state, what is the apolipoprotein stimulator: activated enzyme pair on the adipocyte?
A. apoB48: HSL B. apoB48: LPL C. apoC II :HSL D. . apoC II : LPL

42. What is the covalent modification of acetyl CoA carboxylase 1 (ACC1) in the FED state?
A. acetylation B. deacetylation C. dephosphorylation D. phosphorylation

43. What is the effect of increased glucagon on ACC1 in the hepatocyte?


A. active B. inactive C. unaffected

44. Which of the following enhances secretion of insulin by the  islet cells of the pancreas?
A. FADH2 B. NADH C. NADPH

45. What is the covalent modification on hormone sensitive lipase in response to glucagon in the adipocyte?
A. acetylation B. deacetylation C. dephosphorylation D. phosphorylation
46. Which molecule activates fatty acid synthase (FAS)?
A. acetyl CoA B. malonyl CoA C. NADH D. NADPH

47 Which is the site on FAS that has to be activated?


A. ACP SH B. cysteinyl SH C. both

48 What is vitamin precursor is needed for the desaturation of 16 C FA?


A. thiamine B. pyridoxine C. cyanocobalamin

49. What is the initial process in desaturation of 18C:0 FA?


A. activation B. elongation C. dephosphorylation

50. Palmitoyl CoA will have which covalent modification effect on ACC1?
A. carboxylation B. decarboxylation C. dephosphorylation D. phosphorylation

51. What is the most common product of fatty acid synthesis in humans?
A. 16C: 0 C. 18C: 0 D. 22C:0

52. What fatty acid is the most common product of elongation from FA de novo synthesis?
A. 18C: 0 B. 18 C: 1 9 C. 16C: 0 D. 16C: 1 9

53. Which biochemical process will malic enzyme catalyze to generate NADPH?
A. carboxylation B. decarboxylation C. dephosphorylation D. phosphorylation

54. Which intracellular location do FAs NOT undergo elongation?


A. cytoplasm B. ER C. mitochondria D. nucleus

55. Which lipase would supply glycerol to the liver during FASTED state?
A. ATGL B. HTGL C. HSL D. LPL
UNIVERSITY OF THE EAST
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, INC.
DEPARTMENT OF BIOCHEMISTRY

Quiz # 4.1: LIPOGENESIS

NAME: _____________________________________ SECTION B DATE: _____________


CHOOSE THE BEST ANSWER.
31. Dietary lipids like triacylglycerol (TAGs) are packaged and transported within the gut with which of the following?.
A. bile salts B. chylomicrons C. VLDL

32. Which enzyme would be needed to transport TAGs from the gut to the blood?
A. MTP B .LCAT C. GPAT D.ACAT

33. What is the committed enzyme in lipogenesis?


A. acetyl CoA carboxylase (ACC1) C. HMG CoA synthase (HMGS)
B. malonyl CoA decarboxylase (MCAD) D. HMGCoA reducatse (HMGR)

34. Which enzyme’s product exerts an inhibitory effect on FA oxidation?


A. acetyl CoA carboxylase (ACC1) C. HMG CoA synthase (HMGS)
B. malonyl CoA decarboxylase (MCAD) D. HMGCoA reducatse (HMGR)

35. What is the reducing equivalent required in palmitate synthesis?


A. FADH B. NADH C. NADPH

36. What is the reducing equivalent required for palmitate elongation?


A. FADH B. NADH C. NADPH

37. What is the reducing equivalent required for a 10C elongation?


A. NADH B. NADPH C. both

38. What process will release palmitate from fatty acid synthase (FAS)?
A. decarboxylation B. dehydration C. hydrolysis D. reduction

39. In the fed state, what will be the biological activity :covalent modification pair of ACC1?
A. active: dimerization C. active: polymerization
B. inactive: dimerization D. inactive: polymerization

40. If glucose is the precursor, which intermediate is the direct source of the TAGs backbone?
A. dihydroxyacetone (DHA) C. Glyceraldehyde (GAD)
B. dihydroxyacetone phosphate (DHAP) D. Glyceraldehyde 3-PO4 (GADP)

41. In the fed state, What is the apolipoprotein stimulator: activated enzyme pair on the adipocyte?
A. apoB48: HSL B. apoB48: LPL C. apoC II :HSL D. . apoC II : LPL

42. What is the covalent modification of acetyl CoA carboxylase 1 (ACC1) in the FED state?
A. acetylation B. deacetylation C. dephosphorylation D. phosphorylation

43. What is the effect of increased glucagon on ACC1 in the myocyte?


A. active B. inactive C. unaffected

44. Which of the following enhances secretion of insulin by the  islet cells of the pancreas?
A. FADH2 B. NADH C. NADPH

45. What is the covalent modification on hormone sensitive lipase in response to glucagon in the adipocyte?
A. acetylation B. deacetylation C. dephosphorylation D. phosphorylation
46. Which molecule activates fatty acid synthase (FAS)?
A. acetyl CoA B. malonyl CoA C. NADH D. NADPH

47 Which is the site on FAS that has to be activated?


A. ACP SH B. cysteinyl SH C. both

48 What vitamin precursor is needed for the desaturation of 16 C FA?


A. niacin B. cyanocobalamin C. pyridoxine

49. What is the 1st step in desaturation of 16 C FA?


A. activation B. elongation C. dephosphorylation

50. Palmitoyl CoA will have which covalent modification effect on ACC1?
A. carboxylation B. decarboxylation C. dephosphorylation D. phosphorylation

51. What is the most common product of fatty acid synthesis in humans?
A. 10C: 0 B: 16C: 0 C. 18C: 0 D. 22C:0

52. What fatty acid is the most common product of elongation in the endoplasmic reticulum?
A. 18C: 0 B. 18 C: 1 9 C. 16C: 0 D. 16C: 1 9

53. Which biochemical process will malic enzyme catalyze to generate NADPH?
A. carboxylation B. decarboxylation C. dephosphorylation D. phosphorylation

54. In which intracellular location do FAs undergo elongation?


A.cytoplasm B. ER C. mitochondria D. all

55. Which lipase would supply glycerol to the liver during FASTED state?
A. ATGL B. HTGL C. HSL D. MGL
UNIVERSITY OF THE EAST
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, INC.
DEPARTMENT OF BIOCHEMISTRY

Quiz # 4.1: LIPOGENESIS

NAME: _____________________________________ SECTION C DATE: _____________


CHOOSE THE BEST ANSWER.
31. What is the committed enzyme in lipogenesis?
A. acetyl CoA carboxylase (ACC1) C. HMG CoA synthase (HMGS)
B. malonyl CoA decarboxylase (MCAD) D. HMGCoA reducatse (HMGR)

32. Dietary lipids like triacylglycerol (TAGs) are packaged and transported within the gut with which of the following?.
A. bile salts B. chylomicrons C. VLDL

33. Which enzyme would be needed to transport TAGs from the gut to the blood?
A. MTP B .LCAT C. GPAT D.ACAT

34. What is the most common product of fatty acid synthesis in humans?
A. 10C: 0 B: 16C: 0 C. 18C: 0 D. 22C:0

35. Which enzyme’s product exerts an inhibitory effect on FA oxidation?


A. acetyl CoA carboxylase (ACC1) C. HMG CoA synthase (HMGS)
B. malonyl CoA decarboxylase (MCAD) D. HMGCoA reducatse (HMGR)

36. What is the reducing equivalent required in palmitate synthesis?


A. FADH B. NADH C. NADPH

37. What is the reducing equivalent required for palmitate elongation?


A. FADH B. NADH C. NADPH

38. What process will release palmitate from fatty acid synthase (FAS)?
A. decarboxylation B. dehydration C. hydrolysis D. reduction

39. In the fed state, what will be the biological activity :covalent modification pair of ACC1?
A. active: dimerization C. active: polymerization
B. inactive: dimerization D. inactive: polymerization

40. If glucose is the precursor, which intermediate is the direct source of the TAGs backbone?
A. dihydroxyacetone (DHA) C. Glyceraldehyde (GAD)
B. dihydroxyacetone phosphate (DHAP) D. Glyceraldehyde 3-PO4 (GADP)

41. In the fed state, What is the apolipoprotein stimulator: activated enzyme pair on the adipocyte?
A. apoB48: HSL B. apoB48: LPL C. apoC II :HSL D. . apoC II : LPL

42. What is the covalent modification of acetyl CoA carboxylase 1 (ACC1) in the FED state?
A. acetylation B. deacetylation C. dephosphorylation D. phosphorylation

43. Which lipase would supply glycerol to the liver during FASTED state?
A. ATGL B. HTGL C. HSL D. MGL

44. What is the effect of increased glucagon on ACC1 in the myocyte?


A. active B. inactive C. unaffected

45. Which of the following enhances secretion of insulin by the  islet cells of the pancreas?
A. FADH2 B. NADH C. NADPH

46. What is the covalent modification on hormone sensitive lipase in response to glucagon in the adipocyte?
A. acetylation B. deacetylation C. dephosphorylation D. phosphorylation
47. Which molecule activates fatty acid synthase (FAS)?
A. acetyl CoA B. malonyl CoA C. NADH D. NADPH

48 Which is the site on FAS that has to be activated?


A. ACP SH B. cysteinyl SH C. both

49. What is the reducing equivalent required for a 10C elongation?


A. NADH B. NADPH C. both

50. What vitamin precursor is needed for the desaturation of 16 C FA?


A. riboflavin B. pyridoxine C. cyanocobalamin

51. What is the 1st step in desaturation of 16 C FA?


A. activation B. elongation C. dephosphorylation

52. Palmitoyl CoA will have which covalent modification effect on ACC1?
A. carboxylation B. decarboxylation C. dephosphorylation D. phosphorylation

53. What fatty acid is the most common product of elongation in the endoplasmic reticulum?
A. 18C: 0 B. 18 C: 1 9 C. 16C: 0 D. 16C: 1 9

54. Which biochemical process will malic enzyme catalyze to generate NADPH?
A. carboxylation B. decarboxylation C. dephosphorylation D. phosphorylation

55. In which intracellular location do FAs undergo elongation?


A.cytoplasm B. ER C. mitochondria D. all
UNIVERSITY OF THE EAST
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, INC.
DEPARTMENT OF BIOCHEMISTRY
Quiz # 4.2: LIPOPROTEINS
NAME: _____________________________________ SECTION A DATE: _____________
I. (Nos. 56 – 70) MATCHING TYPE:
Match the lipoprotein (LP) in Column A with the function of the LP in Column B. Choices may be used more than once or not at all.
Column A Column B
A 56. HDL A. harvest free cholesterol(FC) from peripheral cells
C 57. VLDL B. transport dietary TAGs
C 58. IDL C. transport endogenous TAGs
E 59. LDL D. deliver TAGs to liver
B 60. chylomicrons E. deliver FC and CE to peripheral cells

Match the intrinsic apo LP in column A with the LP in Column B. . Choices may be used more than once or not at all.
Column A Column B
B 61. apoA A. chylomicrons
A 62. apoB48 B. HDL
C/D/E 63. apoB100 C. IDL
B 64. apoCII D. LDL
B 65. apoE E. VLDL

Match the LP in column A with the predominant content in Column B. . Choices may be used more than once or not at all.
Column A Column B
A 66. HDL A. proteins
B 67.VLDL B. TAGs
D 68. IDL C. FC and CE (cholesteryl ester)
C 69. LDL D. B &C
B 70. Chylomicrons

II. (Nos. 71 – 80). CHOOSE THE LETTER OF THE BEST ANSWER.


71. According to Statins are expected to lower his cholesterol levels by a MAXIMUM of which %?
A. 80 B. 70 C. 60 D. 50

72. Which process is involved in the cpnversion of cholesterol for fecal excretion??
A. reduction B. hydroxylation C. dehydroxylation

73. Which process is involved in the conversion of cholesterol to primary bile salt?
A. reduction B. hydroxylation C. dehydroxylation

74. Which gene specific transcription factor is directly inactivated by increased blood oxysterols?
A. LXR B. RXR C. SREBP-1c

75. Which drugs will inhibit Nieman Pick C1-like 1 protein function?
A. statins B. resins C. fibrate D. ezetimibe

76. Which apo LP activates LPL?


A. A1 B. B48 C. B100 D. CII

77. Which of the following is the major component of VLDL?


A. esterified cholesterol (CE) B. free cholesterol (FC) C. phospholipids D. TAGs

78. Which Apo LP does LDL-R recognize?


A. A1 B. B48 C. B100 D. CII

79. LPL transports which lipid molecule from LP to adipocyte?


A. esterified cholesterol (CE) B. free cholesterol (FC) C. phospholipids D. TAGs

80. Which is the process by which LDL is taken up by peripheral cells?


A. endocytosis B. exocytosis C. lysosomal degradation D. peroxisomal oxidation
UNIVERSITY OF THE EAST
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, INC.
DEPARTMENT OF BIOCHEMISTRY
Quiz # 4.2: LIPOPROTEINS

NAME: _____________________________________ SECTION B DATE: _____________


II. (Nos. 56-70). MATCHING TYPE.
Match the function of the lipoprotein (LP) in Column A with the LP in Column B. Choices may be used more than once or not at all.
Column A Column B
A 56. harvest free cholesterol (FC) from peripheral cells A. HDL
B 57. transport endogenous TAGs B. VLDL
E 58. transport dietary TAGs C. IDL
D 59. deliver FC and CE(cholesteryl ester) to peripheral cells D. LDL
B 60. transport TAGs to another LP E. chylomicrons

Match the LP in column A with the intrinsic apoLP in Column B. . Choices may be used more than once or not at all.
Column A Column B
A 61. HDL A. apoA
C 62. VLDL B. apoB48
C 63. IDL C. apoB100
C 64. LDL
B 65. Chylomicrons

Match the LP in column A with the predominant content in Column B. . Choices may be used more than once or not at all.
Column A Column B
A 66. HDL A. proteins
B 67.VLDL B. TAGs
D 68. IDL C. FC and CE
C 69. LDL D. B &C
B 70. Chylomicrons

II. (Nos. 71-80). CHOOSE THE LETTER OF THE BEST ANSWER.


71. According to Statins are expected to lower his cholesterol levels by a MAXIMUM of which %?
A.. 80 B. 70 C. 60 D. 50

72. Which process is involved in the cpnversion of cholesterol for fecal excretion??
A. dehydration B. dihydroxylation C. hydroxylation D. reduction .

73. Which position is involved in the conversion of cholesterol to primary bile salts?
A. 3 B. 5 C. 7 D.12

74. Which gene specific transcription factor is directly inactivated by increased blood oxysterols?
A. LXR B. RXR C. SREBP-1c

75. Which drugs will inhibit Nieman Pick C1-like 1 protein function?
A. statins B. resins C. fibrate D. ezetimibe

76. Which apo LP activates LCAT?


A. A1 B. B48 C. B100 D. CII

77. Which of the following is the major component of VLDL?


A. esterified cholesterol (CE) B. free cholesterol (FC) C. phospholipids D. TAGs

78. Which Apo LP activates LPL?


A. A. A1 B. B48 C. B100 D. CII

79. LDL-R functions as receptor for a LP with which apo LP?


A. A1 B. B48 C. B100 D. CII

80. Which is the process by which LDL is taken up by peripheral cells?


A. endocytosis B. exocytosis C. lysosomal degradation D. peroxisomal oxidation
UNIVERSITY OF THE EAST
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, INC.
DEPARTMENT OF BIOCHEMISTRY
Quiz # 4.2: LIPOPROTEINS
NAME: _____________________________________ SECTION C DATE: _____________
I. (Nos. 56 – 70) MATCHING TYPE:
Match the lipoprotein (LP) in Column A with the function of the LP in Column B. Choices may be used more than once or not at all.
Column A Column B
A 56. HDL A. harvest free cholesterol(FC) from peripheral cells
C 57. VLDL B. transport dietary TAGs
C 58. IDL C. transport endogenous TAGs
E 59. LDL D. deliver TAGs to liver
B 60. chylomicrons E. deliver FC and CE to peripheral cells

Match the intrinsic apo LP in column A with the LP in Column B. . Choices may be used more than once or not at all.
Column A Column B
B 61. apoA A. chylomicrons
A 62. apoB48 B. HDL
C/D/E/63. apoB100 C. IDL
B 64. apoCII D. LDL
B 65. apoE E. VLDL

Match the LP in column A with the predominant content in Column B. Choices may be used more than once or not at all.
Column A Column B
A 66. HDL A. proteins
B 67.VLDL B. TAGs
D 68. IDL C. FC and CE (cholesteryl ester)
C 69. LDL D. B &C
B 70. Chylomicrons

II. (Nos. 71 – 80). CHOOSE THE LETTER OF THE BEST ANSWER.


71. Which process is involved in the conversion of cholesterol to primary bile salt?
A. reduction B. hydroxylation C. dehydroxylation

72. Which gene specific transcription factor is directly inactivated by increased blood oxysterols?
A. LXR B. RXR C. SREBP-1c

73. Which drugs will inhibit Nieman Pick C1-like 1 protein function?
A. statins B. resins C. fibrate D. ezetimibe

74. Which apo LP activates LPL?


A. A1 B. B48 C. B100 D. CII

75. Which of the following is the major component of VLDL?


A. esterified cholesterol (CE) B. free cholesterol (FC) C. phospholipids D. TAGs

76. Which Apo LP does LDL-R recognize?


A. A1 B. B48 C. B100 D. CII

77. LPL transports which lipid molecule from LP to adipocyte?


A. esterified cholesterol (CE) B. free cholesterol (FC) C. phospholipids D. TAGs

78. Which is the process by which LDL is taken up by peripheral cells?


A. endocytosis B. exocytosis C. lysosomal degradation D. peroxisomal oxidation

79. According to Statins are expected to lower his cholesterol levels by a MAXIMUM of which %?
A. 80 B. 70 C. 60 D. 50

80. Which process is involved in the conversion of cholesterol for fecal excretion??
A. reduction B. hydroxylation C. dehydroxylation
UNIVERSITY OF THE EAST
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, INC.
DEPARTMENT OF BIOCHEMISTRY
Quiz # 5: β-OXIDATION & KETOGENESIS

NAME: _____________________________________ SECTION A DATE: _____________


CHOOSE THE BEST ANSWER.
81. What is the ATP yield of the complete beta oxidation of a C-20 saturated fatty acid?
A. 45 B. 120 C. 163 D. 165

first 20/2= 10 x12= 120 ATP via KReb cycle, no of spirals is 9 x 5= 45 minus 2 so 163

82. The oxidation of a fatty acid with an Odd number of carbon atoms yields: acetyl coa plus:
A. propionyl CoA B. malonyl CoA C. palmitoyl CoA D. trans enoyl CoA.

83. What does the carnitine shuttle transfer?


A. short chain FA B. medium chain FA C. long chain FA D. very long chain FA

84. Which of the ff scenarios induces KETOSIS?


A. right after a meal C. uncontrolled DM
B. fasting of 2 hours D. dancing for an hour

85. Which of the following enzyme: product pair is correct in the beta oxidation of LCFA?
A. AcylCoA dehydrogenase: L-β hydroxyacylCoA
B. β- hydroxyacylCoA dehydrogenase :β keto acyl CoA
C. EnoylCoA hydratase: fatty acyl coa
D. β keto thiolase: trans fatty enoyl CoA
UNIVERSITY OF THE EAST
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, INC.
DEPARTMENT OF BIOCHEMISTRY
Quiz # 5: β-OXIDATION & KETOGENESIS

NAME: _____________________________________ SECTION B DATE: _____________


CHOOSE THE BEST ANSWER.
81. In which of the following conditions will fatty acids be the major source of fuel for the body?
A. immediately after breakfast C. while running the first mile in a marathon
B. minutes after the snack D. while running the last mile in a marathon
82. Which of the following is TRUE of THIOKINASE?
A. It is called acetyl CoA synthetase
B. It activates docosahexaenoic acid
C. It is present in the ribosomes
D. It utilizes 6 ATP’s in this reaction

It is also called acyl CoA synthetase, I, It only activates LCFA not VLCFA, it is at the inner mitochondrial membrane and
peroxisomal membranest is presenet in the ER

83. Which is TRUE on the oxidation of C19?


A Conversion of Proprionyl CoA to succinyl CoA involves 4 enzymes
B. Malonyl CoA directly enters the Tricarboxylic acid chain
C. Propionyl CoA is formed by the last thiolase cleavage
D. It involves niacin and riboflavin.

84. How many Acetyl CoA is produced by the oxidation of LINOLEIC ACID?
A. 7 B. 8 C.9 D. 10

85. Which of the hormonal changes is compatible with prolonged fasting?


A. ↓ insulin C. ↓ epinephrine
B. ↓ glucagon D. ↓ norepinephrine
UNIVERSITY OF THE EAST
RAMON MAGSAYSAY MEMORIAL MEDICAL CENTER, INC.
DEPARTMENT OF BIOCHEMISTRY
Quiz # 5: β-OXIDATION & KETOGENESIS

NAME: _____________________________________ SECTION C DATE: _____________


CHOOSE THE BEST ANSWER.
81. Which statement describes the activation step of FFA prior to oxidation?
A. Activated by thiokinase C. produces hydroxyacyl CoA
B. Co transported by cobalamin D. yields 2 molecules of ATPS

82. The only glucoeogenic portion of C19 FA enters the TCA via which intermediate?
A.Succinyl CoA C. alpha ketoflutarate
B. Isocitrate D. malate

83. Why are C20 and C 26 FA;s elevated in Zelleweger syndrome?


A. Absence of faaty acyl- coA synthetase C. decreased liver cytochrome 450
B. Defective perixisomal biogenesis D. enhanced carnitine shuttle

84. Compared to adults, which would explain the early onset ketosis in children?
A. ↑Muscle, ↑adipose tissue C. ↓Muscle, ↑adipose tissue
B. ↓Muscle, ↓ adipose tissue D.↑ Muscle, ↓adipose tissue

85. Which of the ff carbonchain FA: transporter pair is correct?


A. CH3( CH2)4COOH: active transport
B. CH3 (CH2)8COOH: chylomicrons
C. CH3 (CH2)14 COOH: carnitine shuttle
D. CH3( CH2) 20COOH: diffusion

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