OASIS-3: IMAGING METHODS AND DATA

DICTIONARY
VERSION 1.6 APRIL 2018

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 1
CONTENTS

Version 1.6 APRIL 2018 ..............................................................................................................................................1

Introduction & Contact Information .............................................................................................................................4

Access to OASIS-3 ......................................................................................................................................................4

Data Use Agreement .................................................................................................................................................4

OASIS Projects and Citations .................................................................................................................................5

Data Releases ............................................................................................................................................................6

Release 1.0: March 2018 .......................................................................................................................................6

Release 1.2: April 2018 ..........................................................................................................................................6

Change Log Records ..............................................................................................................................................6

Using Central.XNAT.ORG ...........................................................................................................................................6

Searching, Reporting, and Data Mining: ................................................................................................................6

Downloading Data .................................................................................................................................................6

Github Resources ......................................................................................................................................................7

Data scripts: Download and Sesssion Matching ....................................................................................................7

Demographics............................................................................................................................................................9

Table 1. Subject Demographics .............................................................................................................................9

Table 2. Clinical Dementia Rating (CDR) ................................................................................................................9

OASIS File Description ...............................................................................................................................................9

MR Images ...........................................................................................................................................................10

PET Images ..........................................................................................................................................................10

Table 3a-c. Scan type inventory ..........................................................................................................................10

Figure 1. Longitudinal Imaging ............................................................................................................................11

MR Imaging .................................................................................................................................................................11

MR Scanners ............................................................................................................................................................11

Scanning Methods ...................................................................................................................................................12

DTI Imaging..........................................................................................................................................................12

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 2
Resting State SCans .............................................................................................................................................13

ASL Parameters ...................................................................................................................................................13

Post-Processed MRI: Volumetric Segmentation..........................................................................................................13

Freesurfer ................................................................................................................................................................13

Processing Background........................................................................................................................................14

Quality Control MEasures....................................................................................................................................14

Analysis Considerations ...........................................................................................................................................14

Correcting subcortical and cortical volumes for head size ..................................................................................14

Additional Regional Calculations .........................................................................................................................16

PET Imaging .................................................................................................................................................................17

PET Scanners .......................................................................................................................................................17

Tracers .....................................................................................................................................................................17

PIB .......................................................................................................................................................................17

AV45 ....................................................................................................................................................................17

FDG ......................................................................................................................................................................17

Post-Processed PET: Pet Unified Pipeline (PUP) ..........................................................................................................18

PUP Variable Nomenclature ................................................................................................................................18

Partial Volume Correction .......................................................................................................................................19

Amyloid PET Imaging Analysis .................................................................................................................................19

Centiloid Conversion for Amyloid PET .................................................................................................................19

Cutoff Values for Amyloid Positivity ....................................................................................................................20

Freesurfer Variables ....................................................................................................................................................22

PUP Variables ..............................................................................................................................................................26

References ...................................................................................................................................................................31

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 3
INTRODUCTION & CONTACT INFORMATION

OASIS-3 is the latest release in the Open Access Series of Imaging Studies (OASIS) that aimed at making
neuroimaging datasets freely available to the scientific community. By compiling and freely distributing this
multi-modal dataset, we hope to facilitate future discoveries in basic and clinical neuroscience. Previously released
data for OASIS-Cross-sectional (Marcus et al, 2007) and OASIS-Longitudinal (Marcus et al, 2010) have been utilized
for hypothesis driven data analyses, development of neuroanatomical atlases, and development of segmentation
algorithms. OASIS-3 is a longitudinal neuroimaging, clinical, cognitive, and biomarker dataset for normal aging and
Alzheimer’s Disease.

The OASIS datasets hosted by central.xnat.org provide the community with open access to a significant database
of neuroimaging and processed imaging data across a broad demographic, cognitive, and genetic spectrum an
easily accessible platform for use in neuroimaging, clinical, and cognitive research on normal aging and cognitive
decline. All data is available via www.oasis-brains.org.

OASIS-3 is a retrospective compilation of data for >1000 participants that were collected across several ongoing
projects through the WUSTL Knight ADRC over the course of 30years. Participants include 609 cognitively normal
adults and 489 individuals at various stages of cognitive decline ranging in age from 42-95yrs. All participants
were assigned a new random identifier and all dates were removed and normalized to reflect days from entry
into study. The dataset contains over 2000 MR sessions which include T1w, T2w, FLAIR, ASL, SWI, time of flight,
resting-state BOLD, and DTI sequences. Many of the MR sessions are accompanied by volumetric segmentation
files produced through Freesurfer processing. PET imaging from 3 different tracers, PIB, AV45, and FDG, totaling
over 1500 raw imaging scans and the accompanying post-processed files from the Pet Unified Pipeline (PUP) are
also available in OASIS-3.

ACCESS TO OASIS-3

Access to OASIS imaging, clinical, and biomarker data is available for access after completing the Data Use
Agreement. Please log all data access requests using the online forms at www.oasis-brains.org.

- Data is available for access at https://central.xnat.org

- Further resources, including updated copies of this Data Dictionary, are available online at www.oasis-
brains.org.
- Both OASIS: Cross-Sectional (OASIS-1) and OASIS: Longitudinal (OASIS-2) are available through the dataset
tabs at www.oasis-brains.org.
- CONTACT INFORMATION: [email protected]

DATA USE AGREEMENT

The OASIS data are distributed to the greater scientific community under the following terms:

1. You will not attempt to establish the identity of to make contact with any of the included human
participants.
2. You will acknowledge the use of OASIS data and data derived from OASIS data when publicly presenting
any results or algorithms that benefitted from their use. Papers, book chapters, books, posters, oral

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 4
presentations, and all other printed and digital presentations of results derived from OASIS data should
contain the following:
a. Acknowledgments: "Data were provided [in part] by OASIS [insert appropriate OASIS source
info]”
i. OASIS: Cross-Sectional: Principal Investigators: D. Marcus, R, Buckner, J, Csernansky J.
Morris; P50 AG05681, P01 AG03991, P01 AG026276, R01 AG021910, P20 MH071616,
U24 RR021382
ii. OASIS: Longitudinal: Principal Investigators: D. Marcus, R, Buckner, J. Csernansky, J.
Morris; P50 AG05681, P01 AG03991, P01 AG026276, R01 AG021910, P20 MH071616,
U24 RR021382
iii. OASIS-3: Principal Investigators: T. Benzinger, D. Marcus, J. Morris; NIH P50AG00561,
P30NS09857781, P01AG026276, P01AG003991, R01AG043434, UL1TR000448,
R01EB009352. AV-45 doses were provided by Avid Radiopharmaceuticals, a wholly
owned subsidiary of Eli Lilly.
b. Citation: The specific publications that are appropriate to cite in any given study will depend on
what OASIS data were used and for what purposes. An annotated and current list of OASIS
publications is available at http://www.oasis-brains.org.
i. OASIS: Cross-Sectional: https://doi.org/10.1162/jocn.2007.19.9.1498
ii. OASIS: Longitudinal: https://doi.org/10.1162/jocn.2009.21407
iii. OASIS-3: https://doi.org/10.1101/2019.12.13.19014902
c. All proposed publications or presentations using Florbetapir F18 (AV45) PET data must be
submitted to Avid Radiopharmaceuticals for review and comment thirty days prior to such
presentation or publication for review of intellectual property interests. See Imaging data
dictionary for contact information and details.
3. You agree to provide the Knight ADRC upon request with information on your use of OASIS data
4. Failure to abide by these data use terms may result in termination of your right to access and use OASIS
data.

AVID CONTACT INFO FOR FLORBETAPIR (AV45) PRESENTATIONS AND PUBLICATIONS

All proposed publications or presentations using Florbetapir F18 (AV45) PET data must be submitted to Avid
Radiopharmaceuticals for review and comment 30 days prior to such presentation or publication for review of
intellectual property interests. Please reference OASIS-brains.org and Washington University (Drs. Morris and
Benzinger) in your email.

- Contacts:
o Elizabeth DiPardo [email protected]
o Patricia Aldea Stevenson <[email protected]>

OASIS PROJECTS AND CITATIONS

Each OASIS project should be used independently and not combined. Due to anonymization
participants may be included in all three datasets under unique IDs.

• OASIS-1: Cross-Sectional T1w MR images across the lifespan (ages 18-96) with dementia status
(doi: 10.1162/jocn.2007.19.9.1498)
• OASIS-2: Longitudinal T1w MR images in older adults (ages 60-96) with dementia status
(doi: 10.1162/jocn.2009.21407)

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 5
• OASIS-3: Longitudinal MR and PET images (ages 42-95) with dementia status (doi.org:
10.1101/2019.12.13.19014902)

DATA RELEASES

RELEASE 1.0: MARCH 2018

- 1098 Subjects (age 42-95)

- Neuroimaging:
o 2118 MR Sessions
§ 1912 Freesurfer processed outputs
o (TBD) PET Sessions
§ 1355 PET Unified Pipeline processed outputs
- Clinical and Cognitive Measures:
o 6217 Longitudinal Clinical follow-up assessments
o 3342 Neuropsychological Assessments
o 4089 NACC UDS Assessments

RELEASE 1.2: APRIL 2018

o 1435 PET Sessions

CHANGE LOG RECORDS

• This is a changelog to track changes to the OASIS database.

o https://github.com/NrgXnat/oasis-scripts/blob/master/OASIS_CHANGELOG.md

USING CENTRAL.XNAT.ORG

SEARCHING, REPORTING, AND DATA MINING:

• Standard Search: https://wiki.xnat.org/documentation/how-to-use-xnat/using-the-standard-search

• Using the Advanced Search: https://wiki.xnat.org/documentation/how-to-use-xnat/using-the-standard-
search/using-the-advanced-search
• Saving a Data Table as a Stored Search: https://wiki.xnat.org/documentation/how-to-use-xnat/using-the-
standard-search/saving-a-data-table-as-a-stored-search
• How to Edit, Filter, and Join Tables: https://wiki.xnat.org/documentation/how-to-use-xnat/using-the-
standard-search/how-to-edit-filter-and-join-data-tables

DOWNLOADING DATA

• How to Download Files via the XNAT REST API (*recommended*):

https://wiki.xnat.org/display/XAPI/How+To+Download+Files+via+the+XNAT+REST+API
• How to Download Images from UI: https://wiki.xnat.org/documentation/how-to-use-xnat/how-to-
download-image-data-from-xnat-projects

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 6
• Troubleshooting XNAT Java Applet Issues: https://wiki.xnat.org/documentation/how-to-use-xnat/image-
session-upload-methods-in-xnat/troubleshooting-xnat-java-applet-issues

GITHUB RESOURCES

DATA SCRIPTS: DOWNLOAD AND SESSSION MATCHING

HTTPS://GITHUB.COM/NRGXNAT/OASIS-SCRIPTS

DOWNLOAD SCANS

o This script downloads scans of a specified type and organizes the files.
§ https://github.com/NrgXnat/oasis-scripts#download_scansdownload_oasis_scanssh
o This script downloads scans from OASIS and organizes the files into Brain Imaging Data Structure
(BIDS) format (See the BIDS website and the BIDS file specification for more details on the BIDS
format).
§ https://github.com/NrgXnat/oasis-scripts#downloading-mr-and-pet-scan-files-in-bids-
format

DOWNLOAD FREESURFER

o The scripts contained in the freesurfer folder can be used to download Freesurfer data and
organize the files.
§ https://github.com/NrgXnat/oasis-scripts#downloading-freesurfer-files

DOWNLOAD PUP

o The scripts contained in the pup folder can be used to download PUP data and organize the files.
§ https://github.com/NrgXnat/oasis-scripts#downloading-pet-unified-pipeline-pup-files

SESSION MATCHUP

o This script takes in two OASIS-3 .csv formatted spreadsheets and matches up the sessions based
on your requested days from entry distance requirements. This script requires R at least version
3.3.0 and the R data.table library minimum version 1.12.8. See the R-project website for more
details on the R language and visit the R data.table library website for more details on the
data.table library.
OASIS-3 data has been anonymized and dates have been eliminated from the data set. OASIS-3
instead uses "days from entry" to note when scan sessions and questionnaire sessions happen

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 7
relative to each other. The "days from entry" variable is seen in OASIS-3 IDs for MR sessions, PET
sessions, Freesurfer assessors, PUP assessors, and questionnaire sessions (such as ADRC Clinical
Data entries or UDS form entries). At the end of each ID is a string d0000 where 0000 is the days
since the subject's entry date into the study. A days from entry value of 0 means that this is the
subject's first visit.
§ https://github.com/NrgXnat/oasis-scripts#matching-up-session-data-by-days-from-
entry

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 8
DEMOGRAPHICS

TABLE 1. SUBJECT DEMOGRAPHICS

N AGE Right Handed

F 611 67.78 (43.2-95.6) 546
M 487 70.17 (42.5-91.7) 433
Total 1098 68.84 (42.5-95.6) 979

TABLE 2. CLINICAL DEMENTIA RATING (CDR)

max CDR
min CDR 0 0.5 1 2 3 Grand
Total
0 605* 192 39 12 2 854
0.5 66 61 45 5 177
>1 31 31 5 67
Grand Total 605 258 131 88 12 1098

*Unchanged CDR = 0 represents cognitively healthy population

OASIS FILE DESCRIPTION

BIDS FILE SPECIFICATION

All MR and PET imaging files are converted to nifti format utilizing the BIDS format (Gorgolewski et al., 2016). This
allows for standardized naming and file formats. Raw MR files, in DICOM or IMA format were converted to Nifti
format using dcm2nii (DICOM=dcm2niix v1.0.20171017 and IMA=dcm2nii mricronlx64-2013.06.12; Li et al., 2016).
Raw PET imaging files were converted to Nifti format using dcm2nii (DICOM=dcm2niix v1.0.20171017 and ECAT7=
dcm2niix v20170428). In addition to nifti files, a supplemental json file is included with additional acquisition
header information, such as scanner model , TR, TE, flip angle, and PET info such as tracer, tracer dose, and
injection timing , that is absent from nifti headers. Frame timing information for PET files can be found in the
accompanying *.tsv file.

Documentation on BIDS can be found here (http://bids.neuroimaging.io/ ).

*Nifti conversion was completed after volumetric processing that has two big implications.

• First, any new processing of T1w.nii images through Freesurfer will result in different values as
documented in FreeSurfer regarding file format changes.
• Second, the T1.mgz associated with the OASIS-3 Freesurfer processing is the result of dicom conversion
to mgz and can be used in place of the T1w.nii file for comparative FreeSurfer processing.

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 9
MR IMAGES
• anat
o T1w
o T2w
o TSE (acq-TSE_T2w)
o T2star
o FLASH
o Flair
o Time of Flight (acq-TOF_angio)
• func
o Task-rest_bold
o asl
• fmap
o Fieldmap
• dwi
o dwi
o bvec (vector table)
o bval (vector of b-values)

• swi
o Magnitude (part-Mag_GRE)
o Phase (part-Phase_GRE)
o Minimum Intensity Projection (minIP)
o swi

PET IMAGES
• pet
o acq-PIB_pet
o acq-AV45_pet

TABLE 3A-C. SCAN TYPE INVENTORY

Scan Type 1.5T MR Sessions 3.0T MR Sessions Total # of MR Session

T1w 236 1881 2117
T2w 230 1755 1985
FLAIR 0 735 735
Bold – Resting State 2 1689 1691
DTI 0 1205 1205
ASL 0 722 722
SWI 2 1217 1219
TOF 1 507 508
Fieldmap 2 977 979
Version 5.0/5.1 Version 5.3 Total
Freesurfer 211 1741 1952

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 10
PET Sessions Processed PUP Data Amyloid Centiloid
PIB 999 937 937
AV45 492 418 418
Total 117 TBD NA

FIGURE 1. LONGITUDINAL IMAGING

Longitudinal Amyloid PET Imaging

MR IMAGING

MR SCANNERS

Data included in OASIS was collected on the following scanners. Scanner specific information is recorded in
dataset_description.json for each MR scan session. For manuscripts, select only the scanner(s) from which your
subset of data were derived.

• Siemens BioGraph mMR PET-MR 3T scanner

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 11
• Siemens TIM Trio 3T MRI scanner (2 scanners)
• Siemens Sonata 1.5T scanner
• Siemens Vision 1.5T scanner

SCANNING METHODS

• Participants were placed in the scanner head to foot while lying in the supine position.
• Head immobilization was done by placing small foam cushions between the head and the head coil.
• In many participants, a Vitamin E capsule was used to mark the left temple.
• For all scans a 16-channel head coil was used.
• Participants receiving simultaneous PET acquisition, on the BioGraph mMR were injected with tracer prior
to initiation of MRI scanning
• Note that not all subjects will have every type of image data.

DTI IMAGING

The OASIS-3 dataset includes 1205 DTI. All sequences include a *bvec and *bval file that includes information on
the vectors and b-values as estimated through the dcm2niix conversion. These files are found in the BIDS folder
associated with the DTI nifti. DTI sequences collected on Siemens scanners are known to have a variance of +/-
10%. Below is the standard vector table for Siemens 25-direction DTI.

VECTOR TABLE FOR 25 DIRECTIONS

CoordinateSystem = xyz
Normalisation = none
Vector[0] = ( -0.200000, 0.000000, 0.000000)
Vector[1] = ( -0.457663, 0.000000, -0.174796)
Vector[2] = ( -0.619678, 0.000000, 0.236674)
Vector[3] = ( -0.647200, -0.420560, 0.210320)
Vector[4] = ( -0.529196, -0.529196, -0.529196)
Vector[5] = ( -0.163313, 0.163313, -0.163313)
Vector[6] = ( -0.305531, 0.305531, 0.305531)
Vector[7] = ( -0.346410, 0.589382, 0.112583)
Vector[8] = ( -0.294225, -0.770361, 0.000000)
Vector[9] = ( -0.334708,-0.876353, 0.000000)
Vector[10] = ( -0.107041, -0.294691, 0.147328)
Vector[11] = ( -0.174797, 0.000000, -0.538023)
Vector[12] = ( -0.222823, 0.000000, 0.685848)
Vector[13] = ( 0.000000, -0.446071, 0.721758)
Vector[14] = ( 0.000000, -0.815963, -0.504234)
Vector[15] = ( 0.000000, -0.142720, -0.373680)
Vector[16] = ( 0.000000, 0.214080, -0.560520)
Vector[17] = ( 0.231234, -0.636606, 0.318265)
Vector[18] = ( 0.435890, -0.458295, -0.599959)
Vector[19] = ( 0.489898, 0.515079, 0.674296)
Vector[20] = ( 0.223607, 0.380445, 0.072672)
Vector[21] = ( 0.365180, 0.365180, -0..365180)
Vector[22] = ( 0.626649, -0.407205, 0.203641)
Vector[23] = ( 0.723592, 0.000000, -0.525744)
Vector[24] = ( 0.809004, 0.000000, 0.587803)

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 12
RESTING STATE SCANS

Resting state scans are labeled according to BIDS standard “task-rest”. Slice timing is included in the JSON when
available. Some original DICOM files did not have slice timing info. When slice timing information is unavailable use
the ratio TR/#slices.

ASL PARAMETERS

The following parameters are important for processing ASL images but were not extracted into the JSON files as
part of the BIDS conversion.

Scanner model Software TI1 TI2 Labeling Slice Background

Version Strategy Readout Suppression
51010 syngo_MR_B18P 700 1900 PASL 46.0ms None
51010 syngo_MR_B20P 700 1900 PASL 46.0ms None
35177 syngo_MR_B17P 700 1900 PASL 36.4ms None
35248 syngo_MR_B17P 700 1800 PASL 36.4ms None

POST-PROCESSED MRI: VOLUMETRIC SEGMENTATION

Single T1w MRI images were processed through Freesurfer to provide volumetric MRI data and segmentations
maps. These maps can be used for a variety of purposes such as determining cortical volumes or regions of interest
(ROIs) for PET imaging.

FREESURFER

OASIS-3 is a retrospective project that required anonymization of all files. In order to anonymize FreeSurfer output
the following were removed: dates, timestamps, QC staff, raw file paths, original directory paths, ID change, and
removal of all logs. OASIS-3 provides volumetric values representing Surface Measures from the aparc.stats
Freesurfer output file and Subcortical Segmentation from the aseg.stats Freesurfer output file. These can be
downloaded in csv format. All additional files, t1.mgz, brainmasks, segmentations, surface maps, and regional
statistics.

*Conversion to BIDS format was completed following FreeSurfer processing.

Segmantation of nifti files will produce different values than segmentation
completed on dicom files and is documented by FreeSurfer. Direct comparison to
OASIS-3 FreeSurfer files should be done using the T1.mgz file.

For a full description of Subcortical Segmentation and Surface Measures statistical variable see list.

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 13
PROCESSING BACKGROUND

FreeSurfer (http://surfer.nmr.mgh.harvard.edu/) analyses involved cortical reconstruction and volumetric

segmentation of T1 weighted images. The technical details of these procedures are described in prior publications
(Dale et al., 1999; Dale and Sereno, 1993; Fischl and Dale, 2000; Fischl et al., 2001; Fischl et al., 2002; Fischl et al.,
2004a; Fischl et al., 1999a; Fischl et al., 1999b; Fischl et al., 2004b; Han et al., 2006; Jovicich et al., 2006; Segonne
et al., 2004)). The processing pipeline included motion correction and segmentation of the subcortical white
matter and deep gray matter volumetric structures on a T1 weighted image (Fischl et al., 2002), intensity
normalization, registration to a spherical atlas which utilized individual cortical folding patterns to match cortical
geometry across subjects (Fischl et al., 1999b), and parcellation of the cerebral cortex into units based on gyral and
sulcal structure (Desikan et al., 2006).

All MRI sessions were processed through the FreeSurfer image analysis suite using Dell PowerEdge 1950 servers
with Intel Xeon processors running CentOS 5.5 Linux.

• All 1.5T imaging data was reprocessed using FreeSurfer 5.0 or Freesurfer 5.1.
• All 3.0T MRI imaging data was reprocessed using FreeSurfer 5.3-HCP-patch.
• All data (1.5 and 3.0 T) have been corrected per the 2012 patch released by MGH.

QUALITY CONTROL MEASURES

All individuals were trained in the FreeSurfer quality control measures developed by the WU ADRC Imaging Core
prior to interacting with the data. Such measures included processing pipeline workflows, visual inspection of the
data for erroneous sessions, and the correct applications of edits to the volumes when errors persist. Additional
information surrounding the FreeSurfer quality control process may be found through the FreeSurfer website,
http://surfer.nmr.mgh.harvard.edu/fswiki/FsTutorial/TroubleshootingData.

OASIS-3 includes FreeSurfer output for sessions that were of quality “pass” or “pass with edits”.

ANALYSIS CONSIDERATIONS

CORRECTING SUBCORTICAL AND CORTICAL VOLUMES FOR HEAD SIZE

It is suggested that all regions volumes should be corrected for head size (intracranial volume, ICV) in order to have
correct comparisons. This does not apply to cortical thickness measures, as cortical thickness does not significantly
vary with head size. The normalization process applies to each individual ROI and is sample specific. Please note if
participants are removed from the data set the normalizations on the subcortical volumes will need to be re-run.

Note: Volume normalization must be repeated every time a subject is added or removed from the sample.

An analysis of the ICV estimate for each participant was performed on a longitudinal cohort (Figure 2). All
participants had MRI scans using a 3T scanner and were processed with FreeSurfer 5.3. Within a participant, ICV
can vary from baseline more than 5% with a mean subject standard deviation of 15.75 cm 3.

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 14
Relevant publication for the head-size correction:
Randy L. Buckner, Denise Head, Jamie Parker, Anthony F. Fotenos, Daniel Marcus, John C. Morris, and
Abraham Z. Snyder A unified approach for morphometric and functional data analysis in young, old, and
demented adults using automated atlas-based head size normalization: reliability and validation against
manual measurement of total intracranial volume. Neuroimage, 2004.

Figure 2. (A) ICV estimate for each participant in a longitudinal study. Each black circle represents an MR session
and the red line represents a longitudinal participant. (B) The relationship between the raw hippocampal volume
and the hippocampal volume normalized by ICV.

INSTRUCTIONS FOR NORMALIZATION OF MRI FREESURFER-DERIVED CORTICAL VOLUMES

Normalization Calculation:

1. Compute mean ICV for sample

2. Compute regression with ICV as independent variable and ROI as dependent variable to obtain B
(NOT Beta) weight
3. Compute: Normalized = raw volume – (B-weight * (ss ICV – mean ICV))
[Note: "ss" = single subject's ]
4. This procedure is repeated for each subcortical & cortical ROI volume the investigator is interested in.
a. These volumes can be found in the "aseg.stats" file.
b. We do not normalize the cortical thickness measures.

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 15
Table 4. below shows a snapshot from the SPSS output for the linear regression. Use the B value highlighted in red
for the correction factor. This will be repeated for each given ROI.

Coefficientsa

Standardized
Unstandardized Coefficients Coefficients
Model B Std. Error Beta t Sig.
1 (Constant) 2718.207 343.943 7.903 .000
ICV -1.513E-5 .000 -.008 -.068 .946
a. Dependent Variable: transtemp

ADDITIONAL REGIONAL CALCULATIONS

Regional FreeSurfer outputs can be combined to generate multiple global brain measures that researchers may
find useful (see https://surfer.nmr.mgh.harvard.edu/fswiki/MorphometryStats):

• Whole Brain Volume = Cortex + CorticalWhiteMatter + SubCortGray

• Cortex = lhCortex + rhCortex
• CorticalWhiteMatter = lhCorticalWhiteMatterVol + rhCorticalWhiteMatterVol
• SubCortGray = summation of thalamus, caudate, hippocampus, amygdala, accumbens, ventral DC,
substanta nigra (if there). This is a simple voxel count of structures identified as subcortical GM.
• Total Ventricular Volume = left and right lateral inferior lateral ventricles + 3rd + 4th + 5th ventricles)

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 16
PET IMAGING

PET SCANNERS

Data included in OASIS was collected on the following scanners. Scanner specific information is recorded in
dataset_description.json for each MR scan session. For manuscripts, select only the scanner(s) from which your
subset of data were derived.

• Siemens Biograph mMR PET-MR 3T scanner (serial#: 51010)

• Siemens Biograph 40 PET/CT scanner (serial#:1003)
• Siemens ECAT HRplus 962 PET scanner

TRACERS

PIB

N-methyl-[11C]2-(4’-methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB) is a radiolabeled compound that binds

in vivo to brain amyloid deposits. Developed at the University of Pittsburgh, PIB has very high affinity for amyloid
plaques. With administration of 6 - 20 mCi of [11C]PIB, a 60 minute dynamic PET scan in 3D mode (septa retracted)
will be initiated (24 x 5 sec frames; 9 x 20 sec frames; 10 x 1 min frames; 9 x 5 min frames).

AV45

Florbetapir binds to β-amyloid (Aβ) plaque utilizing the radioactive isotope 18F for use in PET scanning. Florbetapir
F18 is used udner the research number 18F-AV-45 and therefore referred to as AV45. Participants received a
single i.v. administration of 370 MBq (10 mCi) of florbetapir F 18 (over 10-60 sec). There are two acceptable
procedures for obtaining the florbetapir F 18 PET scans:

1. In the preferred approach, the participant will be positioned in the PET-MR scanner at the time of
injection and a 70-minute dynamic scan (with simultaneous PET and full Standard MR acquisition) will be
obtained starting at the time of injection. For florbetapir F 18 scans conducted on the PET/MR scanner, a
short (approximately 15 minute) CT scan may be conducted on the PET/CT scanner.

2. For those participants who cannot tolerate the full exam, an alternative is to rest quietly in an uptake
room for the first 40 minutes after injection. The participant will then be positioned in the PET-MR
scanner to undergo a scan lasting 20 minutes, beginning 50 minutes after florbetapir F 18 injection and
lasting for 20 minutes, using the Short MR Protocol. For florbetapir F 18 scans conducted on the PET/MR
scanner, a short (approximately 15 minute) CT scan may be conducted on the PET/CT scanner.

FDG

Metabolic imaging with [18F]FDG-PET was performed with a 3D dynamic acquisition began 40 minutes after a
bolus injection of approximately 5 mCi of FDG and lasted for 20 minutes.

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 17
POST-PROCESSED PET: PET UNIFIED PIPELINE (PUP)

PET imaging analyses are performed using the PET unified pipeline (PUP, https://github.com/ysu001/PUP) (Su
2013, Su 2015). PET images are smoothed to achieve a common spatial resolution of 8mm to minimize inter-
scanner differences (Joshi et al., 2009). Inter-frame motion correction for the dynamic PET images is performed
using standard image registration techniques (Hajnal et al., 1995; Eisenstein et al., 2012). PET-MR registration is
performed using a vector-gradient algorithm (VGM; Rowland et al., 2005) in a symmetric fashion (i.e. average
transformation for PET->MR and inverse of MR->PET was used as the final transformation matrix). By default,
regional PET processing is performed based on FreeSurfer segmentation (using wmparc.mgz as the region
definition), and each FreeSurfer region is analyzed. The PET processing pipeline generates both reports of regional
measurements as well as an SUVR image in the individual FreeSurfer space.

PUP VARIABLE NOMENCLATURE

Our data naming convention provides a standard for listing the region and the processing method (Table 5a). Left
and right brain structures use L and R. When left and right are averaged together the suffix includes the
designation TOT. For a full list of variables see PUP Variables. Six prefixes are used:

Table 5a:
Data Type Definition Example Name
fBP_ FreeSurfer calculated Binding Potential fBP_TOT_ACCUMBENS
fBP_rsf_ FreeSurfer calculated, partial volume corrected Binding Potential fBP_rsf_TOT_ACCUMBENS
fSUVR_ FreeSurfer calculated SUVR fSUVR_TOT_ACCUMBENS
fSUVR_rsf_ FreeSurfer calculated, partial volume corrected SUVR, the gold standard fSUVR_rsf_TOT_ACCUMBENS

Table 5b:
Tracer Definition Example Name
PiB [11C]-Pittsburg Compound B PiB_fBP_TOT_ACCUMBENS
AV45 [18F]-Florbetapir AV45_fSUVR_TOT_ACCUMBENS

The prefixes (tracer+processed_outcome) are applied to the SAS correlate suffix to create a descriptive SAS
compliant name (Table 5b).

• PiB_ fSUVR_rsf_TOT_CTX_PRECUNEUS is the [11C] PiB partial volume corrected SUVR of the gray matter
in both the right and left FreeSurfer precuneus.
• PIB_fSUVR_rsf_TOT_WM_PRECUNEUS is the [18F] FDG partial volume corrected SUVR of the white
matter calculated using the average activity in both the right and left FreeSurfer precuneus.
• PIB_fBP_TOT_CORTMEAN is the [18F] FDG average BP of the four MCBP cortical structures using
FreeSurfer regions (TOTFS_PREFRN, TOTFS_TMP, TOTFS_GYREC, TOT_CTX_PRECUNEUS).

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 18
PARTIAL VOLUME CORRECTION

As PET images have low spatial resolution, measured signals are distorted by partial volume effects (PVE). The
distortion caused by PVE is a function of the size and shape of the region of interest in addition to spatial
resolution of the images. In longitudinal studies, the impact of PVE is further confounded by brain atrophy due to
aging and pathological changes. To account for these distortions, correction technique is implemented in our
processing pipeline using a regional spread function (RSF; Rousset 1998) based approach (Su 2015). We have
demonstrated that the RSF technique was able to improve PET quantification and achieve better sensitivity to
longitudinal changes in amyloid burden (Su 2015, 2016). Our standard PET processing includes results both with
and without RSF partial volume correction. Also, SUVR images are only available without partial volume correction
in current analysis.

AMYLOID PET IMAGING ANALYSIS

Currently, two amyloid imaging tracers are used in our studies, i.e. [11C]-Pittsburgh Compound B (PiB) and [18F]-
Florbetapir (AV45). For both tracers, two modeling approaches are implemented: 1) binding potential (BPND) is
calculated using Logan graphical analysis (Logan 1996; Mintun 2006; Su 2013, 2015, 2016), when full dynamic PET
imaging data are available, i.e. PET acquisition was started in synchronization with tracer administration and PET
images were reconstructed into multiple time frames; 2) regional target-to-reference intensity ratio, a.k.a,
standard uptake ratio (SUVR), is estimated for all processable PET data. Under standard protocol, quantitative PET
analysis (both BPND and SUVR) uses 30 to 60 minutes post-injection as the time window for PiB, and 50 to 70
minutes for AV45; and the cerebellum cortex is used as the default reference region. To assess global amyloid
burden based on amyloid PET imaging data, the arithmetic mean of BPND or SUVRs from precuneus (PREC),
prefrontal cortex (PREF), gyrus rectus (GR), and lateral temporal (TEMP) regions are defined as the mean cortical
binding potential (MCBP) or mean cortical SUVR (MCSUVR). In FreeSurfer based processing, PREC is defined as the
combined left and right hemisphere ctx-precuneus, PREF is defined as the left and right combined ctx-
superiorfrontal and ctx-rostralmiddlefrontal regions, GR is defined as the left and right combined ctx-
lateralorbitofrontal and ctx-medialorbitofrontal regions, and TEMP is defined as the left and right combined ctx-
superialtemporal and ctx-middletemporal regions (Fig. 8; Su 2013).

CENTILOID CONVERSION FOR AMYLOID PET

Differences in the amyloid imaging tracer, the PET acquisition, and the analysis protocol across different studies
introduce considerable variability within amyloid PET imaging data. This variability leads to difficulties in
comparing and interpreting amyloid burden results reported from different groups (Klunk et al, 2015). To achieve
comparable results, a standardized scale called Centiloid to convert mean cortical SUVR and BP into a Centiloid
measure of global amyloid disposition. Regional values are unavailable for this dataset.

The procedure and requirements to define the Centiloid scale is documented in detail in the initial Centiloid paper
(Klunk et al 2015). To summarize, the Centiloid scale is defined by two anchor points: the mean amyloid burden
measurement of a young control group with no amyloid pathology in their brain, represented as 0 in the Centiloid
scale, and the mean amyloid burden of an AD group, represented as 100 in the Centiloid scale (level 1 calibration).
Subsequently, a Deming regression and a linear transformation are performed to calibrate the tracer and the local

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 19
processing methods to the Centiloid scale (i.e. level 2 calibration). Both PiB and AV45 have been calibrated to the
Centiloid scale for both non-partial volume and partial volume correction (rsf) using standard PUP (Su, in prep).

Table 6. Examples of the conversion between non-partial volume corrected SUVR and BP to their respective
Centiloid value.

Centiloid Value PiB 30-60 min PiB 30-60 min

BP SUVR
-10 -0.0442 0.9776
0 0.0347 1.0671
25 0.2320 1.2907
50 0.4294 1.5143
75 0.6267 1.7379
100 0.8240 1.9615
110 0.9029 2.0510

CUTOFF VALUES FOR AMYLOID POSITIVITY

Traditionally, the cutoff for amyloid positivity has been established as MCBP>0.18 based on manually processed
PiB data (Mintun 2006). We also established that the same cutoff could be used for FreeSurfer processing
generated MCBP based on a study population of 77 participants (Su 2013). Based on this dataset, the cutoff for
MCSUVRRSF was determined to be 1.42, the cutoff values for additional versions of global amyloid burden
measurements that would generate best matched amyloid positivity classification as using manual MCBP=0.18 are
also determined. For AV45, the equivalent cutoff to PiB MCSUVRRSF>1.42 was determined based on a sporadic AD
cohort of 103 participants who had AV45-PiB crossover data based on the regression line between AV45 MCSUVRs
and PiB MCSUVRRSF (Fig. 3) (Su 2018). The equivalent cutoffs in Centiloid units were also derived by applying the
Centiloid conversion equations to the native measurement cutoffs.

Figure 3. PiB-AV45 crossover dataset illustrating the relationship between AV45 based mean cortical
SUVR and PiB based mean cortical SUVRs.

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 20
Table 7.

Amyloid Positivity Cutoffs - Cerebellar Cortex Reference Region

PIB MCBP 0.18

PIB MCBP RSF 0.37
PIB MCSUVR 1.31
PIB MCUSVR RSF 1.42
AV45 MCSUVR 1.24 *
AV45 MCSUVR RSF 1.19 *
Amyloid Positivity Cutoffs – Brainstem Reference Region

PIB MCSUVR BS 0.79

PIB MCUSVR RSF BS 0.72
Amyloid Positivity Cutoffs - Centiloid

CL PIB MCBP 18.2

CL PIB MCUSVR RSF 16.4
CL AV45 MCSUVR 21.9
CL AV45 MCSUVR RSF 20.6

* see Su et al 2018.

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 21
FREESURFER VARIABLES

Below is a list of the Freesurfer variables as found in OASIS-3 and a suggested list of SAS compatible labels.

MRI Freesurer Default Variable SAS Compatible Variable Labels

3rd-Ventricle MR_TOTV_THIRDVENT
4th-Ventricle MR_TOTV_FOURTHVENT
5th-Ventricle MR_TOTV_FIFTHVENT
Brain-Stem MR_TOTV_BRAINSTEM
CC_Anterior MR_TOTV_CRPCLM_ANT
CC_Central MR_TOTV_CRPCLM_CNTRL
CC_Mid_Anterior MR_TOTV_CRPCLM_MID_ANT
CC_Mid_Posterior MR_TOTV_CRPCLM_MID_POST
CC_Posterior MR_TOTV_CRPCLM_POST
CortexVol MR_TOTV_CORTEX
CSF MR_TOTV_CSF
IntraCranialVol MR_TOTV_INTRACRANIAL
non-WM-hypointensities MR_TOTV_NONWMHYPOINTENSITIES
Optic-Chiasm MR_TOTV_OPTICHIASM
SubCortGrayVol MR_TOTV_SUBCORTGRAY
TotalGrayVol MR_TOTV_GRAY
WM-hypointensities MR_TOTV_WMHYPOINTENSITIES
lh_bankssts_thickness MR_LT_SSTSBANK
lh_caudalanteriorcingulate_thickness MR_LT_CAUDANTCNG
lh_caudalmiddlefrontal_thickness MR_LT_CAUDMIDFRN
lh_cuneus_thickness MR_LT_CUNEUS
lh_entorhinal_thickness MR_LT_ENTORHINAL
lh_frontalpole_thickness MR_LT_FRNPOLE
lh_fusiform_thickness MR_LT_FUSIFORM
lh_inferiorparietal_thickness MR_LT_INFRPRTL
lh_inferiortemporal_thickness MR_LT_INFRTMP
lh_insula_thickness MR_LT_INSULA
lh_isthmuscingulate_thickness MR_LT_ISTHMUSCNG
lh_lateraloccipital_thickness MR_LT_LATOCC
lh_lateralorbitofrontal_thickness MR_LT_LATORBFRN
lh_lingual_thickness MR_LT_LINGUAL
lh_medialorbitofrontal_thickness MR_LT_MEDORBFRN
lh_middletemporal_thickness MR_LT_MIDTMP
lh_paracentral_thickness MR_LT_PARACNTRL
lh_parahippocampal_thickness MR_LT_PARAHPCMPL
lh_parsopercularis_thickness MR_LT_PARAOPRCLRS
lh_parsorbitalis_thickness MR_LT_PARSORBLS
lh_parstriangularis_thickness MR_LT_PARSTRNGLRS
lh_pericalcarine_thickness MR_LT_PERICLCRN
lh_postcentral_thickness MR_LT_POSTCNTRL
lh_posteriorcingulate_thickness MR_LT_POSTCNG
lh_precentral_thickness MR_LT_PRECNTRL
lh_precuneus_thickness MR_LT_PRECUNEUS
lh_rostralanteriorcingulate_thickness MR_LT_ROSANTCNG
lh_rostralmiddlefrontal_thickness MR_LT_ROSMIDFRN
lh_superiorfrontal_thickness MR_LT_SUPERFRN
lh_superiorparietal_thickness MR_LT_SUPERPRTL
lh_superiortemporal_thickness MR_LT_SUPERTMP
lh_supramarginal_thickness MR_LT_SUPRAMRGNL
lh_temporalpole_thickness MR_LT_TMPPOLE
lh_transversetemporal_thickness MR_LT_TRANSTMP
rh_bankssts_thickness MR_RT_SSTSBANK
rh_caudalanteriorcingulate_thickness MR_RT_CAUDANTCNG
rh_caudalmiddlefrontal_thickness MR_RT_CAUDMIDFRN

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 22
rh_cuneus_thickness MR_RT_CUNEUS
rh_entorhinal_thickness MR_RT_ENTORHINAL
rh_frontalpole_thickness MR_RT_FRNPOLE
rh_fusiform_thickness MR_RT_FUSIFORM
rh_inferiorparietal_thickness MR_RT_INFRPRTL
rh_inferiortemporal_thickness MR_RT_INFRTMP
rh_insula_thickness MR_RT_INSULA
rh_isthmuscingulate_thickness MR_RT_ISTHMUSCNG
rh_lateraloccipital_thickness MR_RT_LATOCC
rh_lateralorbitofrontal_thickness MR_RT_LATORBFRN
rh_lingual_thickness MR_RT_LINGUAL
rh_medialorbitofrontal_thickness MR_RT_MEDORBFRN
rh_middletemporal_thickness MR_RT_MIDTMP
rh_paracentral_thickness MR_RT_PARACNTRL
rh_parahippocampal_thickness MR_RT_PARAHPCMPL
rh_parsopercularis_thickness MR_RT_PARAOPRCLRS
rh_parsorbitalis_thickness MR_RT_PARSORBLS
rh_parstriangularis_thickness MR_RT_PARSTRNGLRS
rh_pericalcarine_thickness MR_RT_PERICLCRN
rh_postcentral_thickness MR_RT_POSTCNTRL
rh_posteriorcingulate_thickness MR_RT_POSTCNG
rh_precentral_thickness MR_RT_PRECNTRL
rh_precuneus_thickness MR_RT_PRECUNEUS
rh_rostralanteriorcingulate_thickness MR_RT_ROSANTCNG
rh_rostralmiddlefrontal_thickness MR_RT_ROSMIDFRN
rh_superiorfrontal_thickness MR_RT_SUPERFRN
rh_superiorparietal_thickness MR_RT_SUPERPRTL
rh_superiortemporal_thickness MR_RT_SUPERTMP
rh_supramarginal_thickness MR_RT_SUPRAMRGNL
rh_temporalpole_thickness MR_RT_TMPPOLE
rh_transversetemporal_thickness MR_RT_TRANSTMP
Left-Accumbens-area MR_LV_ACCUMBENS
Left-Amygdala MR_LV_AMYGDALA
Left-Caudate MR_LV_CAUD
Left-Cerebellum-Cortex MR_LV_CBLL_CORTEX
Left-Cerebellum-White-Matter MR_LV_CBLL_WM
Left-choroid-plexus MR_LV_CHORPLEX
Left-Hippocampus MR_LV_HIPPOCAMPUS
Left-Inf-Lat-Vent MR_LV_INFLATVENT
Left-Lateral-Ventricle MR_LV_LATVENT
Left-non-WM-hypointensities MR_LV_NONWMHYPOINTENSITIES
Left-Pallidum MR_LV_PALLIDUM
Left-Putamen MR_LV_PUTAMEN
Left-Thalamus-Proper MR_LV_THALAMUS
Left-VentralDC MR_LV_VENTRALDC
Left-vessel MR_LV_VESSEL
Left-WM-hypointensities MR_LV_WMHYPOINTENSITIES
lh_bankssts_volume MR_LV_SSTSBANK
lh_caudalanteriorcingulate_volume MR_LV_CAUDANTCNG
lh_caudalmiddlefrontal_volume MR_LV_CAUDMIDFRN
lh_cuneus_volume MR_LV_CUNEUS
lh_entorhinal_volume MR_LV_ENTORHINAL
lh_frontalpole_volume MR_LV_FRNPOLE
lh_fusiform_volume MR_LV_FUSIFORM
lh_inferiorparietal_volume MR_LV_INFRPRTL
lh_inferiortemporal_volume MR_LV_INFRTMP
lh_insula_volume MR_LV_INSULA
lh_isthmuscingulate_volume MR_LV_ISTHMUSCNG
lh_lateraloccipital_volume MR_LV_LATOCC
lh_lateralorbitofrontal_volume MR_LV_LATORBFRN
lh_lingual_volume MR_LV_LINGUAL
lh_medialorbitofrontal_volume MR_LV_MEDORBFRN
lh_middletemporal_volume MR_LV_MIDTMP

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 23
lh_paracentral_volume MR_LV_PARACNTRL
lh_parahippocampal_volume MR_LV_PARAHPCMPL
lh_parsopercularis_volume MR_LV_PARAOPRCLRS
lh_parsorbitalis_volume MR_LV_PARSORBLS
lh_parstriangularis_volume MR_LV_PARSTRNGLRS
lh_pericalcarine_volume MR_LV_PERICLCRN
lh_postcentral_volume MR_LV_POSTCNTRL
lh_posteriorcingulate_volume MR_LV_POSTCNG
lh_precentral_volume MR_LV_PRECNTRL
lh_precuneus_volume MR_LV_PRECUNEUS
lh_rostralanteriorcingulate_volume MR_LV_ROSANTCNG
lh_rostralmiddlefrontal_volume MR_LV_ROSMIDFRN
lh_superiorfrontal_volume MR_LV_SUPERFRN
lh_superiorparietal_volume MR_LV_SUPERPRTL
lh_superiortemporal_volume MR_LV_SUPERTMP
lh_supramarginal_volume MR_LV_SUPRAMRGNL
lh_temporalpole_volume MR_LV_TMPPOLE
lh_transversetemporal_volume MR_LV_TRANSTMP
lhCortexVol MR_LV_CORTEX
lhCorticalWhiteMatterVol MR_LV_CORTICALWM
rh_bankssts_volume MR_RV_SSTSBANK
rh_caudalanteriorcingulate_volume MR_RV_CAUDANTCNG
rh_caudalmiddlefrontal_volume MR_RV_CAUDMIDFRN
rh_cuneus_volume MR_RV_CUNEUS
rh_entorhinal_volume MR_RV_ENTORHINAL
rh_frontalpole_volume MR_RV_FRNPOLE
rh_fusiform_volume MR_RV_FUSIFORM
rh_inferiorparietal_volume MR_RV_INFRPRTL
rh_inferiortemporal_volume MR_RV_INFRTMP
rh_insula_volume MR_RV_INSULA
rh_isthmuscingulate_volume MR_RV_ISTHMUSCNG
rh_lateraloccipital_volume MR_RV_LATOCC
rh_lateralorbitofrontal_volume MR_RV_LATORBFRN
rh_lingual_volume MR_RV_LINGUAL
rh_medialorbitofrontal_volume MR_RV_MEDORBFRN
rh_middletemporal_volume MR_RV_MIDTMP
rh_paracentral_volume MR_RV_PARACNTRL
rh_parahippocampal_volume MR_RV_PARAHPCMPL
rh_parsopercularis_volume MR_RV_PARAOPRCLRS
rh_parsorbitalis_volume MR_RV_PARSORBLS
rh_parstriangularis_volume MR_RV_PARSTRNGLRS
rh_pericalcarine_volume MR_RV_PERICLCRN
rh_postcentral_volume MR_RV_POSTCNTRL
rh_posteriorcingulate_volume MR_RV_POSTCNG
rh_precentral_volume MR_RV_PRECNTRL
rh_precuneus_volume MR_RV_PRECUNEUS
rh_rostralanteriorcingulate_volume MR_RV_ROSANTCNG
rh_rostralmiddlefrontal_volume MR_RV_ROSMIDFRN
rh_superiorfrontal_volume MR_RV_SUPERFRN
rh_superiorparietal_volume MR_RV_SUPERPRTL
rh_superiortemporal_volume MR_RV_SUPERTMP
rh_supramarginal_volume MR_RV_SUPRAMRGNL
rh_temporalpole_volume MR_RV_TMPPOLE
rh_transversetemporal_volume MR_RV_TRANSTMP
rhCortexVol MR_RV_CORTEX
rhCorticalWhiteMatterVol MR_RV_CORTICALWM
Right-Accumbens-area MR_RV_ACCUMBENS
Right-Amygdala MR_RV_AMYGDALA
Right-Caudate MR_RV_CAUD
Right-Cerebellum-Cortex MR_RV_CBLL_CORTEX
Right-Cerebellum-White-Matter MR_RV_CBLL_WM
Right-choroid-plexus MR_RV_CHORPLEX
Right-Hippocampus MR_RV_HIPPOCAMPUS

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 24
Right-Inf-Lat-Vent MR_RV_INFLATVENT
Right-Lateral-Ventricle MR_RV_LATVENT
Right-non-WM-hypointensities MR_RV_NONWMHYPOINTENSITIES
Right-Pallidum MR_RV_PALLIDUM
Right-Putamen MR_RV_PUTAMEN
Right-Thalamus-Proper MR_RV_THALAMUS
Right-VentralDC MR_RV_VENTRALDC
Right-vessel MR_RV_VESSEL
Right-WM-hypointensities MR_RV_WMHYPOINTENSITIES

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 25
PUP VARIABLES

Below is a list of the Pet Unified Pipeline (PUP) variables as found in OASIS-3 and a suggested list of SAS compatible
labels. The prefixes (tracer+processed_outcome) are applied to the SAS correlate suffix to create a descriptive SAS
compliant name (ex: PiB_mSUVR_TOT_ACCUMBENS).

Structure Name SAS Compatible Variable Labels

Accumbens_area TOT_ACCUMBENS
Amygdala TOT_AMYGDALA
Brain_Stem TOT_BRAINSTEM
Caudate TOT_CAUD
CC_Anterior CRPCLM_ANT
CC_Central CRPCLM_CNTRL
CC_Mid_Anterior CRPCLM_MID_ANT
CC_Mid_Posterior CRPCLM_MID_POST
CC_Posterior CRPCLM_POST
Cerebellum_Cortex TOT_CBLL_CORTEX
Cerebellum_White_Matter TOT_CBLL_WM
choroid_plexus TOT_CHORPLEX
ctx_bankssts TOT_CTX_SSTSBANK
ctx_caudalanteriorcingulate TOT_CTX_CAUDANTCNG
ctx_caudalmiddlefrontal TOT_CTX_CAUDMIDFRN
ctx_corpuscallosum TOT_CTX_CRPCLM
ctx_cuneus TOT_CTX_CUNEUS
ctx_entorhinal TOT_CTX_ENTORHINAL
ctx_frontalpole TOT_CTX_FRNPOLE
ctx_fusiform TOT_CTX_FUSIFORM
ctx_inferiorparietal TOT_CTX_INFERPRTL
ctx_inferiortemporal TOT_CTX_INFERTMP
ctx_insula TOT_CTX_INSULA
ctx_isthmuscingulate TOT_CTX_ISTHMUSCNG
ctx_lateraloccipital TOT_CTX_LATOCC
ctx_lateralorbitofrontal TOT_CTX_LATORBFRN
ctx_lh_bankssts L_CTX_SSTSBANK
ctx_lh_caudalanteriorcingulate L_CTX_CAUDANTCNG
ctx_lh_caudalmiddlefrontal L_CTX_CAUDMIDFRN
ctx_lh_corpuscallosum L_CTX_CRPCLM
ctx_lh_cuneus L_CTX_CUNEUS
ctx_lh_entorhinal L_CTX_ENTORHINAL
ctx_lh_frontalpole L_CTX_FRNPOLE
ctx_lh_fusiform L_CTX_FUSIFORM
ctx_lh_inferiorparietal L_CTX_INFRPRTL
ctx_lh_inferiortemporal L_CTX_INFRTMP
ctx_lh_insula L_CTX_INSULA
ctx_lh_isthmuscingulate L_CTX_ISTHMUSCNG
ctx_lh_lateraloccipital L_CTX_LATOCC
ctx_lh_lateralorbitofrontal L_CTX_LATORBFRN
ctx_lh_lingual L_CTX_LINGUAL
ctx_lh_medialorbitofrontal L_CTX_MEDORBFRN
ctx_lh_middletemporal L_CTX_MIDTMP
ctx_lh_paracentral L_CTX_PARACNTRL
ctx_lh_parahippocampal L_CTX_PARAHPCMPL
ctx_lh_parsopercularis L_CTX_PARSOPRCLRS
ctx_lh_parsorbitalis L_CTX_PARSORBLS
ctx_lh_parstriangularis L_CTX_PARSTRNGLRS
ctx_lh_pericalcarine L_CTX_PERICLCRN
ctx_lh_postcentral L_CTX_POSTCNTRL
ctx_lh_posteriorcingulate L_CTX_POSTCNG
ctx_lh_precentral L_CTX_PRECNTRL
ctx_lh_precuneus L_CTX_PRECUNEUS

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 26
ctx_lh_rostralanteriorcingulate L_CTX_ROSANTCNG
ctx_lh_rostralmiddlefrontal L_CTX_ROSMIDFRN
ctx_lh_superiorfrontal L_CTX_SUPERFRN
ctx_lh_superiorparietal L_CTX_SUPERPRTL
ctx_lh_superiortemporal L_CTX_SUPERTMP
ctx_lh_supramarginal L_CTX_SUPRAMRGNL
ctx_lh_temporalpole L_CTX_TMPPOLE
ctx_lh_transversetemporal L_CTX_TRANSTMP
ctx_lingual TOT_CTX_LINGUAL
ctx_medialorbitofrontal TOT_CTX_MEDORBFRN
ctx_middletemporal TOT_CTX_MIDTMP
ctx_paracentral TOT_CTX_PARACNTRL
ctx_parahippocampal TOT_CTX_PARAHPCMPL
ctx_parsopercularis TOT_CTX_PARSOPCLRS
ctx_parsorbitalis TOT_CTX_PARSORBLS
ctx_parstriangularis TOT_CTX_PARSTRNGLS
ctx_pericalcarine TOT_CTX_PERICLCRN
ctx_postcentral TOT_CTX_POSTCNTRL
ctx_posteriorcingulate TOT_CTX_POSTCNG
ctx_precentral TOT_CTX_PRECNTRL
ctx_precuneus TOT_CTX_PRECUNEUS
ctx_rh_bankssts R_CTX_SSTSBANK
ctx_rh_caudalanteriorcingulate R_CTX_CAUDANTCNG
ctx_rh_caudalmiddlefrontal R_CTX_CAUDMIDFRN
ctx_rh_corpuscallosum R_CTX_CRPCLM
ctx_rh_cuneus R_CTX_CUNEUS
ctx_rh_entorhinal R_CTX_ENTORHINAL
ctx_rh_frontalpole R_CTX_FRNPOLE
ctx_rh_fusiform R_CTX_FUSIFORM
ctx_rh_inferiorparietal R_CTX_INFPRTL
ctx_rh_inferiortemporal R_CTX_INFTMP
ctx_rh_insula R_CTX_INSULA
ctx_rh_isthmuscingulate R_CTX_ISTHMUSCNG
ctx_rh_lateraloccipital R_CTX_LATOCC
ctx_rh_lateralorbitofrontal R_CTX_LATORBFRN
ctx_rh_lingual R_CTX_LINGUAL
ctx_rh_medialorbitofrontal R_CTX_MEDORBFRN
ctx_rh_middletemporal R_CTX_MIDTMP
ctx_rh_paracentral R_CTX_PARACNTRL
ctx_rh_parahippocampal R_CTX_PARAHPCMPL
ctx_rh_parsopercularis R_CTX_PARSOPRCLRS
ctx_rh_parsorbitalis R_CTX_PARSORBLS
ctx_rh_parstriangularis R_CTX_PARSTRNGLRS
ctx_rh_pericalcarine R_CTX_PERICLCRN
ctx_rh_postcentral R_CTX_POSTCNTRL
ctx_rh_posteriorcingulate R_CTX_POSTCNG
ctx_rh_precentral R_CTX_PRECNTRL
ctx_rh_precuneus R_CTX_PRECUNEUS
ctx_rh_rostralanteriorcingulate R_CTX_ROSANTCNG
ctx_rh_rostralmiddlefrontal R_CTX_ROSMIDFRN
ctx_rh_superiorfrontal R_CTX_SUPERFRN
ctx_rh_superiorparietal R_CTX_SUPERPRTL
ctx_rh_superiortemporal R_CTX_SUPERTMP
ctx_rh_supramarginal R_CTX_SUPRAMRGNL
ctx_rh_temporalpole R_CTX_TMPPOLE
ctx_rh_transversetemporal R_CTX_TRANSTMP
ctx_rostralanteriorcingulate TOT_CTX_ROSANTCNG
ctx_rostralmiddlefrontal TOT_CTX_ROSMIDFRN
ctx_superiorfrontal TOT_CTX_SUPERFRN
ctx_superiorparietal TOT_CTX_SUPERPRTL
ctx_superiortemporal TOT_CTX_SUPERTMP
ctx_supramarginal TOT_CTX_SUPRAMRGNL
ctx_temporalpole TOT_CTX_TMPPOLE

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 27
ctx_transversetemporal TOT_CTX_TRANSTMP
GR_FS TOTFS_GYREC
Hippocampus TOT_HIPPOCAMPUS
Left_Accumbens_area L_ACCUMBENS
Left_Amygdala L_AMYGDALA
Left_Caudate L_CAUD
Left_Cerebellum_Cortex L_CTX_CBLL
Left_Cerebellum_White_Matter L_WM_CBLL
Left_choroid_plexus L_CHORPLEX
Left_Hippocampus L_HIPPOCAMPUS
Left_Pallidum L_PALLIDUM
Left_Putamen L_PUTAMEN
Left_Substancia_Nigra L_SUBSTNCA_NGRA
Left_Thalamus_Proper L_THALAMUS
Left_UnsegmentedWhiteMatter L_WM_UNSEGMENTED
Left_VentralDC L_VENTRALDC
OCC_FS TOTFS_OCC
Pallidum TOT_PALLIDUM
PREF_FS TOTFS_PREFRN
Putamen TOT_PUTAMEN
Right_Accumbens_area R_ACCUMBENS
Right_Amygdala R_AMYGDALA
Right_Caudate R_CAUD
Right_Cerebellum_Cortex R_CTX_CBLL
Right_Cerebellum_White_Matter R_WM_CBLL
Right_choroid_plexus R_CHORPLEX
Right_Hippocampus R_HIPPOCAMPUS
Right_Pallidum R_PALLIDUM
Right_Putamen R_PUTAMEN
Right_Substancia_Nigra R_SUBSTNCA_NGRA
Right_Thalamus_Proper R_THALAMUS
Right_UnsegmentedWhiteMatter R_WM_UNSEGMENTED
Right_VentralDC R_VENTRALDC
Substancia_Nigra TOT_SUBSTNCA_NGRA
TEMP_FS TOTFS_TMP
Thalamus_Proper TOT_THALAMUS_PRPR
UnsegmentedWhiteMatter TOT_WM_UNSEGMENTED
VentralDC TOT_VENTRALDC
wm_bankssts TOT_WM_SSTSBNK
wm_caudalanteriorcingulate TOT_WM_CAUDANTCNG
wm_caudalmiddlefrontal TOT_WM_CAUDMIDFRN
wm_corpuscallosum TOT_WM_CRPCLM
wm_cuneus TOT_WM_CUNEUS
wm_entorhinal TOT_WM_ENTORHINAL
wm_frontalpole TOT_WM_FRNPOLE
wm_fusiform TOT_WM_FUSIFORM
wm_inferiorparietal TOT_WM_INFERPRTL
wm_inferiortemporal TOT_WM_INFERTMP
wm_insula TOT_WM_INSULA
wm_isthmuscingulate TOT_WM_ISTHMUSCNG
wm_lateraloccipital TOT_WM_LATOCC
wm_lateralorbitofrontal TOT_WM_LATORBFRN
wm_lh_bankssts L_WM_SSTSBANK
wm_lh_caudalanteriorcingulate L_WM_CAUDANTCNG
wm_lh_caudalmiddlefrontal L_WM_CAUDMIDFRN
wm_lh_corpuscallosum L_WM_CRPCLM
wm_lh_cuneus L_WM_CUNEUS
wm_lh_entorhinal L_WM_ENTORHINAL
wm_lh_frontalpole L_WM_FRNPOLE
wm_lh_fusiform L_WM_FUSIFORM
wm_lh_inferiorparietal L_WM_INFPRTL
wm_lh_inferiortemporal L_WM_INFTMP
wm_lh_insula L_WM_INSULA

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 28
wm_lh_isthmuscingulate L_WM_ISTHMUSCNG
wm_lh_lateraloccipital L_WM_LATOCC
wm_lh_lateralorbitofrontal L_WM_LATORBFRN
wm_lh_lingual L_WM_LINGUAL
wm_lh_medialorbitofrontal L_WM_MEDORBFRN
wm_lh_middletemporal L_WM_MIDTMP
wm_lh_paracentral L_WM_PARACNTRL
wm_lh_parahippocampal L_WM_PARAHPCMPL
wm_lh_parsopercularis L_WM_PARSOPRCLRS
wm_lh_parsorbitalis L_WM_PARSORBLS
wm_lh_parstriangularis L_WM_PARSTRIANGLRS
wm_lh_pericalcarine L_WM_PERICLCRN
wm_lh_postcentral L_WM_POSTCNTRL
wm_lh_posteriorcingulate L_WM_POSTCNG
wm_lh_precentral L_WM_PRECNTRL
wm_lh_precuneus L_WM_PRECUNEUS
wm_lh_rostralanteriorcingulate L_WM_ROSANTCNG
wm_lh_rostralmiddlefrontal L_WM_ROSMIDFRN
wm_lh_superiorfrontal L_WM_SUPERFRN
wm_lh_superiorparietal L_WM_SUPERPRTL
wm_lh_superiortemporal L_WM_SUPERTMP
wm_lh_supramarginal L_WM_SUPRAMRGNL
wm_lh_temporalpole L_WM_TMPPOLE
wm_lh_transversetemporal L_WM_TRANSTMP
wm_lingual TOT_WM_LINGUAL
wm_medialorbitofrontal TOT_WM_MEDORBFRN
wm_middletemporal TOT_WM_MIDTMP
wm_paracentral TOT_WM_PARACNTRL
wm_parahippocampal TOT_WM_PARAHPCMPL
wm_parsopercularis TOT_WM_PARSOPRCLRS
wm_parsorbitalis TOT_WM_PARSORBLS
wm_parstriangularis TOT_WM_PARSTRNGLRS
wm_pericalcarine TOT_WM_PERICLCRN
wm_postcentral TOT_WM_POSTCNTRL
wm_posteriorcingulate TOT_WM_POSTCNG
wm_precentral TOT_WM_PRECNTRL
wm_precuneus TOT_WM_PRECUNEUS
wm_rh_bankssts R_WM_SSTSBANK
wm_rh_caudalanteriorcingulate R_WM_CAUDANTCNG
wm_rh_caudalmiddlefrontal R_WM_CAUDMIDFRN
wm_rh_corpuscallosum R_WM_CRPCLM
wm_rh_cuneus R_WM_CUNEUS
wm_rh_entorhinal R_WM_ENTORHINAL
wm_rh_frontalpole R_WM_FRNPOLE
wm_rh_fusiform R_WM_FUSIFORM
wm_rh_inferiorparietal R_WM_INFERIORPRTL
wm_rh_inferiortemporal R_WM_INFERIORTMP
wm_rh_insula R_WM_INSULA
wm_rh_isthmuscingulate R_WM_ISTHMUSCNG
wm_rh_lateraloccipital R_WM_LATOCC
wm_rh_lateralorbitofrontal R_WM_LATORBFRN
wm_rh_lingual R_WM_LINGUAL
wm_rh_medialorbitofrontal R_WM_MEDORBFRN
wm_rh_middletemporal R_WM_MIDTMP
wm_rh_paracentral R_WM_PARACNTRL
wm_rh_parahippocampal R_WM_PARAHPCMPL
wm_rh_parsopercularis R_WM_PARSOPRCLRS
wm_rh_parsorbitalis R_WM_PARSORBLS
wm_rh_parstriangularis R_WM_PARSTRNGLRS
wm_rh_pericalcarine R_WM_PERICLCRN
wm_rh_postcentral R_WM_POSTCNTRL
wm_rh_posteriorcingulate R_WM_POSTCNG
wm_rh_precentral R_WM_PRECNTRL

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 29
wm_rh_precuneus R_WM_PRECUNEUS
wm_rh_rostralanteriorcingulate R_WM_ROSANTCNG
wm_rh_rostralmiddlefrontal R_WM_ROSMIDFRN
wm_rh_superiorfrontal R_WM_SUPERFRN
wm_rh_superiorparietal R_WM_SUPERPRTL
wm_rh_superiortemporal R_WM_SUPERTMP
wm_rh_supramarginal R_WM_SUPRAMRGNL
wm_rh_temporalpole R_WM_TMPPOLE
wm_rh_transversetemporal R_WM_TRANSTMP
wm_rostralanteriorcingulate TOT_WM_ROSANTCNG
wm_rostralmiddlefrontal TOT_WM_ROSMIDFRN
wm_superiorfrontal TOT_WM_SUPERFRN
wm_superiorparietal TOT_WM_SUPERPRTL
wm_superiortemporal TOT_WM_SUPERTMP
wm_supramarginal TOT_WM_SUPRAMRGNL
wm_temporalpole TOT_WM_TMPPOLE
wm_transversetemporal TOT_WM_TRANSTMP
MCBP TOT_CORTMEAN

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 30
REFERENCES
1. Gorgolewski, K.J., et al. The brain imaging data structure, a format for organizing and describing
outputs of neuroimaging experiments. Sci Data 2016; 3:160044. PMID: 27326542 PMCID:
PMC4978148 DOI: 10.1038/sdata.2016.44.
2. Li, X, Morgan, P.S., Ashburner, J., Smith, J., Rorden, C. The first step for neuroimaging data analysis:
DICOM to NIfTI conversion. J Neurosci Methods 2016; 164:47-56. PMID:26945974 DOI:
10.1016/j.jneumeth.2016.03.001.
3. Chien DT, Bahri S, Szardenings AK, Walsh JC, Mu F, Su M-Y, et al. Early Clinical PET Imaging Results
with the Novel PHF-Tau Radioligand [F-18]-T807. J. Alzheimer’s Dis. 2013; 34: 457–468.
4. Eisenstein, S.A., Koller, J.M., Piccirillo, M., Kim, A., Antenor-Dorsey, J.A., Videen, T.O., Snyder, A.Z.,
Karimi, M., Moerlein, S.M., Black, K.J., Perlmutter, J.S., Hershey, T., 2012. Characterization of
extrastriatal D2 in vivo specific binding of [(1)(8)F](N-methyl)benperidol using PET. Synapse 66, 770-
780.
5. Fischl B. FreeSurfer. NeuroImage 2012; 62(2):774-781. PMCID: PMC: 222857
6. Frouin V, Comtat C, Reilhac A, Gre ǵ oire MC. Correction of Partial-Volume Effect for PET Striatal
Imaging: Fast Implementation and Study of Robustness. J Nucl Med 2002; 43:1715–1726
7. Hajnal, J.V., Saeed, N., Soar, E.J., Oatridge, A., Young, I.R., Bydder, G.M., 1995. A registration and
interpolation procedure for subvoxel matching of serially acquired MR images. J Comput Assist
Tomogr 19, 289-296.
8. Joshi, A., Koeppe, R.A., Fessler, J.A., 2009. Reducing between scanner differences in multi-center PET
studies. Neuroimage 46, 154-159.
9. Klunk WE, Engler H, Nordberg A, Wang,Y, Blomqvist G, Holt DP, Bergstrom M, Savitcheva I, Huang GF,
Estrada S, Ausen B, Debnath ML, Barletta J, Price JC, Sandell J, Lopresti BJ, Wall A, Koivisto P, Antoni
G, Mathis CA, Langstrom B. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-
B. Ann Neurol 2004; 55, 306-319.
10. Klunk WE, Koeppe RA, Price JC, Benzinger TL, Devous MD Sr, Jagust WJ, Johnson KA, Mathis CA,
Minhas D, Pontecorvo MJ, Rowe CC, Skovronsky DM, Mintun MA. The Centiloid Project: Standardizing
quantitative amyloid plaque estimation by PET. Alzheimer’s & Dementia 2015; 11(1):1-15.e4.
11. Logan J, Fowler AH, Volkow ND. Distribution volume ratios without blood sampling from graphical
analysis of PET data. J Cereb Blood Flow Metab 1996; 16:834–840.
12. Lopresti BJ, Klunk WE, Mathis CA, Hoge JA, Ziolko SK, Lu X, Meltzer CC, Schimmel K, Tsopelas ND,
DeKosky ST, Price JC. Simplified quantification of Pittsburgh Compound B amyloid imaging PET
studies: a comparative analysis. J Nucl Med 2005; 46:1959-1972.
13. Marcus, DS, Archie, KA, Olsen, T, Ramaratnam, M. The open source neuroimaging research
enterprise. J. Digital Imaging 2007; 20:130-138.
14. McCormick LM, Ziebell S, Nopoulos P, Cassell M, Andreasen NC, Brumm M. Anterior Cingulate Cortex:
An MRI-based parcellation method. NeuroImage 2006; 32:1167-1175.
15. Mintun MA, LaRossa GN, Sheline YI, Dence CS, Lee SY, Mach RH, Klunk WE, Mathis CA, DeKosky ST,
Morris JC. [11C]PIB in a nondemented population: Potential antecedent marker of Alzheimer disease.
Neurology 2006; 67;446-452
16. Shruti, M, Gordon BA, Su, Y, Christensen, J, Friedrichsen, K, Jackson K, Hornbeck, R, Balota DM, Cairns,
N, Ances, B, Morris, JC. Benzinger TLS. Tau PET imaging in preclinical Alzheimer’s Disease: Classifying
tau Positivity. NeuroImage 2017; 161: 171-178
17. Morris, JC, Roe, CM, Xiong, C, Fagan, AM, Goate, AM, Holtzman, DM, Mintun, MA. APOE predicts
amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Ann Neurol 2010; 67:122-
131.

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 31
18. Ostrowitzki S, Deptula D, Thurfjell L, Barkhof F, Bohrmann B, Brooks DJ, Klunk WE, Ashford E, Yoo K,
Xu ZX, Loetscher H, Santarelli L. Mechanism of amyloid removal in patients with Alzheimer disease
treated with gantenerumab. Arch Neurol 2011; 69:198-207
19. Price TR, Manolio TA, Kronmal RA, Kittner SJ, Yue NC, Robbins J, Anton-Culver H, O'Leary DH. Silent
brain infarction on magnetic resonance imaging and neurological abnormalities in community-
dwelling older adults. The Cardiovascular Health Study. CHS Collaborative Research Group. Stroke.
1997;28(6):1158-64. PMID: 9183343.
20. Robb, R.A., Hanson, D.P., Karwoski, R.A., Larson, A.G., Workman, E.L., Stacy, M.C. Analyze: a
comprehensive, operator-interactive software package for multidimensional medical image display
and analysis. Comput Med Imaging Graph 1989; 13:433-454.
21. Rousset O, Ma Y, Evans A. Correction for partial volume effects in PET: principle and validation. J Nucl
Med 1998; 39:904–11.
22. Rousset O, Zaidi H. Correction of partial volume effects in emission tomography. In: Zaidi H, ed- itor.
Quantitative analysis of nuclear medicine images. New York: Springer; 2006. p. 236–271.
23. Rowland DJ, Garbow JR, Laforest R, Snyder AZ. 2005 Registration of [18F]FDG microPET and small-
animal MRI. Nucl Med Biol 2005; 32:567-72
24. Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR, Jr., Kaye J,
Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, Yaffe K, Carrillo MC, Thies B, Morrison-
Bogorad M, Wagster MV, Phelps CH. Toward defining the preclinical stages of Alzheimer's disease:
recommendations from the National Institute on Aging-Alzheimer's Association workgroups on
diagnostic guidelines for Alzheimer's disease. Alzheimer's & dementia. 2011;7(3):280-92. PMID:
21514248; PMCID: PMC3220946
25. Su Y, D'Angelo GM, Vlassenko AG, Zhou GF, Snyder AZ, Marcus DS, et al. Quantitative Analysis of PiB-
PET with FreeSurfer ROIs. PLoS One 2013;8(11):e73377. PMCID: 3819320
26. Su Y, Blazey TM, Snyder AZ, Raichle ME, Marcus DS, Ances BM, Bateman RJ, Cairns NJ, Aldea P, Cash
L, Christensen JJ, Friedrichsen K, Hornbeck RC, Farrar AM, Owen CJ, Mayeux R, Brickman AM, Klunk
W, Price JC, Thompson PM, Ghetti B, Saykin AJ, Sperling RA, Johnson KA, Schofield PR, Buckles V,
Morris JC, Benzinger TL, Network DIA. Partial volume correction in quantitative amyloid imaging.
Neuroimage. 2015;107:55-64. PMCID: 4300252.
27. Su Y, Blazey TM, Owen CJ, Christensen JJ, Friedrichsen K, Joseph-Mathurin N, Wang Q, Hornbeck RC,
Ances BM, Snyder AZ, Cash LA, Koeppe RA, Klunk WE, Galasko D, Brickman AM, McDade E, Ringman
JM, Thompson PM, Saykin AJ, Ghetti B, Sperling RA, Johnson KA, Salloway SP, Schofield PR, Masters
CL, Villemagne VL, Fox NC, Forster S, Chen K, Reiman EM, Xiong C, Marcus DS, Weiner MW, Morris JC,
Bateman RJ, Benzinger TL, Dominantly Inherited Alzheimer N. Quantitative Amyloid Imaging in
Autosomal Dominant Alzheimer's Disease: Results from the DIAN Study Group. PLoS One.
2016;11(3):e0152082. PMCID: PMC4807073.
28. Su Y, Flores S, Wang G, Hornbeck RC, Speidel B, Vlassenko AG, Gordon BA, Mintun MA, Koeppe RA,
Klunk WE, McDade E, Xiong C, Morris JC, Bateman R, Benzinger TL. Comparison of Pittsburg
Compound B and Florbetapir in Cross-sectional and Longitudinal Studies. 2018. Manuscript in
preparation.
29. Talairach J, Tournoux P. Co-planar Stereotaxic Atlas of the Human Brain: 3-D Proportional System: An
Approach to Cerebral Imaging. Stuttgart, Germany: Thieme Medical Publishers; 1988.
30. Wahlund LO, Barkhof F, Fazekas F, Bronge L, Augustin M, Sjogren M, Wallin A, Ader H, Leys D, Pantoni
L, Pasquier F, Erkinjuntti T, Scheltens P. A new rating scale for age-related white matter changes
applicable to MRI and CT. Stroke. 2001;32(6):1318-22. PMID: 11387493.

OASIS-3 Imaging Methods & Data Dictionary Version 1.8 Data Release: 1.2 Page | 32